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Literature summary extracted from

  • Haidari, F.; Ali Keshavarz, S.; Reza Rashidi, M.; Mohammad Shahi, M.
    Orange juice and hesperetin supplementation to hyperuricemic rats alter oxidative stress markers and xanthine oxidoreductase activity (2009), J. Clin. Biochem. Nutr., 45, 285-291.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.17.1.4 allopurinol shows strong enzyme inhibition and hypouricemic effect Rattus norvegicus
1.17.1.4 hesperetin i.e. 3',5,7-trihydroxy-4'-methoxyflavanone, major flavanone component of orange juice, inhibits hepatic XDH activity and decreases serum uric acid levels, exhibits antioxidative and antihyperuricemic properties Rattus norvegicus
1.17.1.4 additional information orange juice inhibits hepatic XDH activity and decreases serum uric acid levels and exhibits antioxidative and antihyperuricemic properties Rattus norvegicus
1.17.3.2 allopurinol shows strong enzyme inhibition and hypouricemic effect Rattus norvegicus
1.17.3.2 hesperetin i.e. 3',5,7-trihydroxy-4'-methoxyflavanone, major flavanone component of orange juice, inhibits hepatic XOR activity and decreases serum uric acid levels, exhibits antioxidative and antihyperuricemic properties Rattus norvegicus
1.17.3.2 orange juice inhibits hepatic XOR activity and decreases serum uric acid levels and exhibits antioxidative and antihyperuricemic properties Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.17.1.4 cytosol
-
 Rattus norvegicus 5829
-
1.17.3.2 cytosol
-
 Rattus norvegicus 5829
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.17.1.4 Mo XOR is a molybdenum-containing enzyme Rattus norvegicus
1.17.3.2 Mo XOR is a molybdenum-containing enzyme Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.17.1.4 additional information Rattus norvegicus enzyme inhibition by orange juice and hesperetin participates in preventing oxidative stress by enhancing total antioxidant capacity and decreasing lipid peroxidation, overview ?
-
 ?
1.17.1.4 xanthine + NAD+ + H2O Rattus norvegicus
-
 urate + NADH + H+
-
 ?
1.17.3.2 additional information Rattus norvegicus enzyme inhibition by orange juice and hesperetin participates in preventing oxidative stress by enhancing total antioxidant capacity and decreasing lipid peroxidation, overview ?
-
 ?
1.17.3.2 xanthine + O2 + H2O Rattus norvegicus
-
 urate + H2O2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.17.1.4 Rattus norvegicus
-
 male Wistar rats
-
1.17.3.2 Rattus norvegicus
-
 male Wistar rats
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.17.1.4 liver
-
 Rattus norvegicus
-
1.17.3.2 liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.17.1.4 additional information enzyme inhibition by orange juice and hesperetin participates in preventing oxidative stress by enhancing total antioxidant capacity and decreasing lipid peroxidation, overview Rattus norvegicus ?
-
 ?
1.17.1.4 xanthine + NAD+ + H2O
-
 Rattus norvegicus urate + NADH + H+
-
 ?
1.17.3.2 additional information enzyme inhibition by orange juice and hesperetin participates in preventing oxidative stress by enhancing total antioxidant capacity and decreasing lipid peroxidation, overview Rattus norvegicus ?
-
 ?
1.17.3.2 xanthine + O2 + H2O
-
 Rattus norvegicus urate + H2O2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.17.1.4 XDH
-
 Rattus norvegicus
1.17.3.2 XOR
-
 Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
1.17.1.4 molybdenum cofactor molybdenum-containing enzyme Rattus norvegicus
1.17.1.4 NAD+
-
 Rattus norvegicus
1.17.3.2 molybdenum cofactor molybdenum-containing enzyme Rattus norvegicus