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Literature summary extracted from

  • Murata, K.; Nakao, K.; Hirata, N.; Namba, K.; Nomi, T.; Kitamura, Y.; Moriyama, K.; Shintani, T.; Iinuma, M.; Matsuda, H.
    Hydroxychavicol: a potent xanthine oxidase inhibitor obtained from the leaves of betel, Piper betle (2009), J. Nat. Med., 63, 355-359.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.17.3.2 allopurinol
-
 Bos taurus
1.17.3.2 hydroxychavicol i.e. 4-allyl-1,3-hydroxybenzene, a potent xanthine oxidase inhibitor obtained from the leaves of betel, Piper betle. Structure-activity relationships, the dihydroxyl group is required for the xanthine oxidase inhibitory activity, overview Bos taurus
1.17.3.2 additional information eugenol, methyleugenol, and dihydromethyleugenol are poor inhibitors Bos taurus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.17.3.2 xanthine + O2 + H2O Bos taurus
-
 urate + H2O2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.17.3.2 Bos taurus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.17.3.2 commercial preparation
-
 Bos taurus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.17.3.2 xanthine + O2 + H2O
-
 Bos taurus urate + H2O2
-
 ?

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.17.3.2 0.0167
-
-
 Bos taurus hydroxychavicol
1.17.3.2 0.0307
-
-
 Bos taurus allopurinol

General Information

EC Number General Information Comment Organism
1.17.3.2 metabolism xanthine oxidase is a key enzyme in the purine metabolic pathway, catalysing the oxidation of hypoxanthine to uric acid Bos taurus