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Literature summary extracted from

  • Skinner, R.; Trujillo, A.; Ma, X.; Beierle, E.
    Ketone bodies inhibit the viability of human neuroblastoma cells (2009), J. Pediatr. Surg., 44, 212-216.
    View publication on PubMed

Application

EC Number Application Comment Organism
2.8.3.5 medicine dietary manipulation using ketone bodies in accordance with SCOT expression may be a novel therapeutic strategy for neuroblastoma Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.8.3.5 succinyl-CoA + acetoacetate Homo sapiens
-
 succinate + acetoacetyl-CoA
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.8.3.5 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.8.3.5 fibroblast from foreskin Homo sapiens
-
2.8.3.5 HFF-1 cell
-
 Homo sapiens
-
2.8.3.5 neuroblastoma cell decreased expression of SCOT protein, neuroblastoma cells are unable to use ketone bodies as an energy source Homo sapiens
-
2.8.3.5 SK-N-AS cell decreased expression of SCOT protein, neuroblastoma cells are unable to use ketone bodies as an energy source Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.8.3.5 succinyl-CoA + acetoacetate
-
 Homo sapiens succinate + acetoacetyl-CoA
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.8.3.5 SCOT
-
 Homo sapiens
2.8.3.5 succinyl-coenzyme A:3-oxoacid coenzyme A transferase
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
2.8.3.5 succinyl-CoA
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
2.8.3.5 metabolism SCOT is a key enzyme involved in ketone body metabolism Homo sapiens