Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Wu, D.; Wu, X.D.; You, X.F.; Ma, X.F.; Tian, W.X.
    Inhibitory effects on bacterial growth and b-ketoacyl-ACP reductase by different species of maple leaf extracts and tannic acid (2009), Phytother. Res., 24, 535-541.
No PubMed abstract available

Application

EC Number Application Comment Organism
1.1.1.100 drug development FabG is the antibacteria target of maple leaf extracts and tannic acid, and both reversible and irreversible inhibitions of FabG are important for the antibacterial effect Salmonella enterica subsp. enterica serovar Typhimurium
1.1.1.100 drug development FabG is the antibacteria target of maple leaf extracts and tannic acid, and both reversible and irreversible inhibitions of FabG are important for the antibacterial effect Staphylococcus aureus
1.1.1.100 drug development FabG is the antibacteria target of maple leaf extracts and tannic acid, and both reversible and irreversible inhibitions of FabG are important for the antibacterial effect Escherichia coli
1.1.1.100 drug development FabG is the antibacteria target of maple leaf extracts and tannic acid, and both reversible and irreversible inhibitions of FabG are important for the antibacterial effect Enterobacter cloacae
1.1.1.100 drug development FabG is the antibacteria target of maple leaf extracts and tannic acid, and both reversible and irreversible inhibitions of FabG are important for the antibacterial effect Klebsiella aerogenes
1.1.1.100 drug development FabG is the antibacteria target of maple leaf extracts and tannic acid, and both reversible and irreversible inhibitions of FabG are important for the antibacterial effect Pseudomonas aeruginosa
1.1.1.100 drug development FabG is the antibacteria target of maple leaf extracts and tannic acid, and both reversible and irreversible inhibitions of FabG are important for the antibacterial effect Acinetobacter calcoaceticus
1.1.1.100 drug development FabG is the antibacteria target of maple leaf extracts and tannic acid, and both reversible and irreversible inhibitions of FabG are important for the antibacterial effect Serratia marcescens
1.1.1.100 drug development FabG is the antibacteria target of maple leaf extracts and tannic acid, and both reversible and irreversible inhibitions of FabG are important for the antibacterial effect Proteus vulgaris
1.1.1.100 drug development FabG is the antibacteria target of maple leaf extracts and tannic acid, and both reversible and irreversible inhibitions of FabG are important for the antibacterial effect Klebsiella pneumoniae
1.1.1.100 drug development FabG is the antibacteria target of maple leaf extracts and tannic acid, and both reversible and irreversible inhibitions of FabG are important for the antibacterial effect Staphylococcus epidermidis
1.1.1.100 drug development FabG is the antibacteria target of maple leaf extracts and tannic acid, and both reversible and irreversible inhibitions of FabG are important for the antibacterial effect Salmonella enterica subsp. enterica serovar Typhi
1.1.1.100 drug development FabG is the antibacteria target of maple leaf extracts and tannic acid, and both reversible and irreversible inhibitions of FabG are important for the antibacterial effect Shigella sonnei
1.1.1.100 drug development FabG is the antibacteria target of maple leaf extracts and tannic acid, and both reversible and irreversible inhibitions of FabG are important for the antibacterial effect Shigella dysenteriae
1.1.1.100 drug development FabG is the antibacteria target of maple leaf extracts and tannic acid, and both reversible and irreversible inhibitions of FabG are important for the antibacterial effect Shigella flexneri
1.1.1.100 drug development FabG is the antibacteria target of maple leaf extracts and tannic acid, and both reversible and irreversible inhibitions of FabG are important for the antibacterial effect Enterococcus sp.

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.1.1.100 His-tagged FabG expressed in Escherichia coli strain BL21 (DE3) Escherichia coli

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.100 additional information inhibition by leaf extracts from Acer platanoides, Acer campestre, Acer rubrum, Acer saccharum and Acer truncatum Bunge Acinetobacter calcoaceticus
1.1.1.100 additional information inhibition by leaf extracts from Acer platanoides, Acer campestre, Acer rubrum, Acer saccharum and Acer truncatum Bunge Enterobacter cloacae
1.1.1.100 additional information inhibition by leaf extracts from Acer platanoides, Acer campestre, Acer rubrum, Acer saccharum and Acer truncatum Bunge Enterococcus sp.
1.1.1.100 additional information inhibition by leaf extracts from Acer platanoides, Acer campestre, Acer rubrum, Acer saccharum and Acer truncatum Bunge; inhibition by leaf extracts from Acer platanoides, Acer campestre, Acer rubrum, Acer saccharum and Acer truncatum Bunge. Leaf extracts of Acer saccharum and Acer truncatum Bunge display time-dependent irreversible inhibition of FabG, whereas leaf extracts of Acer platanoides, Acer campestre and Acer rubrum show reversible inhibition Escherichia coli
1.1.1.100 additional information inhibition by leaf extracts from Acer platanoides, Acer campestre, Acer rubrum, Acer saccharum and Acer truncatum Bunge Klebsiella aerogenes
1.1.1.100 additional information inhibition by leaf extracts from Acer platanoides, Acer campestre, Acer rubrum, Acer saccharum and Acer truncatum Bunge Klebsiella pneumoniae
1.1.1.100 additional information inhibition by leaf extracts from Acer platanoides, Acer campestre, Acer rubrum, Acer saccharum and Acer truncatum Bunge. Is inhibited by the leaf extracts from all five kinds of maples more effectively than are other Gram-negative bacteria strains Proteus vulgaris
1.1.1.100 additional information inhibition by leaf extracts from Acer platanoides, Acer campestre, Acer rubrum, Acer saccharum and Acer truncatum Bunge Pseudomonas aeruginosa
1.1.1.100 additional information inhibition by leaf extracts from Acer platanoides, Acer campestre, Acer rubrum, Acer saccharum and Acer truncatum Bunge. Is inhibited by the leaf extracts from all five kinds of maples more effectively than are other Gram-negative bacteria strains Salmonella enterica subsp. enterica serovar Typhi
1.1.1.100 additional information inhibition by leaf extracts from Acer platanoides, Acer campestre, Acer rubrum, Acer saccharum and Acer truncatum Bunge Salmonella enterica subsp. enterica serovar Typhimurium
1.1.1.100 additional information inhibition by leaf extracts from Acer platanoides, Acer campestre, Acer rubrum, Acer saccharum and Acer truncatum Bunge Serratia marcescens
1.1.1.100 additional information inhibition by leaf extracts from Acer platanoides, Acer campestre, Acer rubrum, Acer saccharum and Acer truncatum Bunge. Is inhibited by the leaf extracts from all five kinds of maples more effectively than are other Gram-negative bacteria strains Shigella dysenteriae
1.1.1.100 additional information inhibition by leaf extracts from Acer platanoides, Acer campestre, Acer rubrum, Acer saccharum and Acer truncatum Bunge Shigella flexneri
1.1.1.100 additional information inhibition by leaf extracts from Acer platanoides, Acer campestre, Acer rubrum, Acer saccharum and Acer truncatum Bunge Shigella sonnei
1.1.1.100 additional information inhibition by leaf extracts from Acer platanoides, Acer campestre, Acer rubrum, Acer saccharum and Acer truncatum Bunge Staphylococcus aureus
1.1.1.100 additional information inhibition by leaf extracts from Acer platanoides, Acer campestre, Acer rubrum, Acer saccharum and Acer truncatum Bunge, except strain 04-5 Staphylococcus epidermidis
1.1.1.100 quercetin
-
Escherichia coli
1.1.1.100 Tannic acid
-
Acinetobacter calcoaceticus
1.1.1.100 Tannic acid
-
Enterobacter cloacae
1.1.1.100 Tannic acid
-
Enterococcus sp.
1.1.1.100 Tannic acid strongest inhibition on FabG, shows time-dependent irreversible inhibition Escherichia coli
1.1.1.100 Tannic acid
-
Klebsiella aerogenes
1.1.1.100 Tannic acid
-
Klebsiella pneumoniae
1.1.1.100 Tannic acid
-
Proteus vulgaris
1.1.1.100 Tannic acid
-
Pseudomonas aeruginosa
1.1.1.100 Tannic acid
-
Salmonella enterica subsp. enterica serovar Typhi
1.1.1.100 Tannic acid
-
Salmonella enterica subsp. enterica serovar Typhimurium
1.1.1.100 Tannic acid
-
Serratia marcescens
1.1.1.100 Tannic acid
-
Shigella dysenteriae
1.1.1.100 Tannic acid
-
Shigella flexneri
1.1.1.100 Tannic acid
-
Shigella sonnei
1.1.1.100 Tannic acid displays very strong inhibition Staphylococcus aureus
1.1.1.100 Tannic acid displays very strong inhibition Staphylococcus epidermidis

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.100 Acinetobacter calcoaceticus
-
-
-
1.1.1.100 Acinetobacter calcoaceticus 25001
-
-
-
1.1.1.100 Enterobacter cloacae
-
-
-
1.1.1.100 Enterobacter cloacae 45301
-
-
-
1.1.1.100 Enterococcus sp.
-
strains ATCC29212 and 775
-
1.1.1.100 Escherichia coli
-
-
-
1.1.1.100 Escherichia coli
-
strains ATCC 25922 and 26
-
1.1.1.100 Klebsiella aerogenes
-
-
-
1.1.1.100 Klebsiella aerogenes 45102
-
-
-
1.1.1.100 Klebsiella pneumoniae
-
strains ATCC700603 and 14
-
1.1.1.100 Proteus vulgaris
-
-
-
1.1.1.100 Pseudomonas aeruginosa
-
strains ATCC27853 and 17
-
1.1.1.100 Salmonella enterica subsp. enterica serovar Typhi
-
-
-
1.1.1.100 Salmonella enterica subsp. enterica serovar Typhi H901
-
-
-
1.1.1.100 Salmonella enterica subsp. enterica serovar Typhimurium
-
-
-
1.1.1.100 Serratia marcescens
-
-
-
1.1.1.100 Serratia marcescens 41002
-
-
-
1.1.1.100 Shigella dysenteriae
-
-
-
1.1.1.100 Shigella flexneri
-
-
-
1.1.1.100 Shigella sonnei
-
-
-
1.1.1.100 Shigella sonnei 51592
-
-
-
1.1.1.100 Staphylococcus aureus
-
strains ATCC29213, 15 and 05-3
-
1.1.1.100 Staphylococcus epidermidis
-
strains ATCC12228, 04-5 and 05-1
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.1.1.100 by nickel chelation affinity chromatography Escherichia coli

Storage Stability

EC Number Storage Stability Organism
1.1.1.100 -80°C, 50% glycerol Escherichia coli

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.100 ethyl acetoacetate + NADPH
-
Escherichia coli ? + NADP+
-
?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.100 beta-ketoacyl-ACP reductase
-
Salmonella enterica subsp. enterica serovar Typhimurium
1.1.1.100 beta-ketoacyl-ACP reductase
-
Staphylococcus aureus
1.1.1.100 beta-ketoacyl-ACP reductase
-
Escherichia coli
1.1.1.100 beta-ketoacyl-ACP reductase
-
Enterobacter cloacae
1.1.1.100 beta-ketoacyl-ACP reductase
-
Klebsiella aerogenes
1.1.1.100 beta-ketoacyl-ACP reductase
-
Pseudomonas aeruginosa
1.1.1.100 beta-ketoacyl-ACP reductase
-
Acinetobacter calcoaceticus
1.1.1.100 beta-ketoacyl-ACP reductase
-
Serratia marcescens
1.1.1.100 beta-ketoacyl-ACP reductase
-
Proteus vulgaris
1.1.1.100 beta-ketoacyl-ACP reductase
-
Klebsiella pneumoniae
1.1.1.100 beta-ketoacyl-ACP reductase
-
Staphylococcus epidermidis
1.1.1.100 beta-ketoacyl-ACP reductase
-
Salmonella enterica subsp. enterica serovar Typhi
1.1.1.100 beta-ketoacyl-ACP reductase
-
Shigella sonnei
1.1.1.100 beta-ketoacyl-ACP reductase
-
Shigella dysenteriae
1.1.1.100 beta-ketoacyl-ACP reductase
-
Shigella flexneri
1.1.1.100 beta-ketoacyl-ACP reductase
-
Enterococcus sp.
1.1.1.100 FabG
-
Salmonella enterica subsp. enterica serovar Typhimurium
1.1.1.100 FabG
-
Staphylococcus aureus
1.1.1.100 FabG
-
Escherichia coli
1.1.1.100 FabG
-
Enterobacter cloacae
1.1.1.100 FabG
-
Klebsiella aerogenes
1.1.1.100 FabG
-
Pseudomonas aeruginosa
1.1.1.100 FabG
-
Acinetobacter calcoaceticus
1.1.1.100 FabG
-
Serratia marcescens
1.1.1.100 FabG
-
Proteus vulgaris
1.1.1.100 FabG
-
Klebsiella pneumoniae
1.1.1.100 FabG
-
Staphylococcus epidermidis
1.1.1.100 FabG
-
Salmonella enterica subsp. enterica serovar Typhi
1.1.1.100 FabG
-
Shigella sonnei
1.1.1.100 FabG
-
Shigella dysenteriae
1.1.1.100 FabG
-
Shigella flexneri
1.1.1.100 FabG
-
Enterococcus sp.

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.100 NADPH
-
Escherichia coli

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.1.1.100 0.00078
-
-
Escherichia coli Tannic acid