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Literature summary extracted from

  • Kashiwagi, T.; Leung, B.W.; Deng, T.; Chen, H.; Brownlee, G.G.
    The N-terminal region of the PA subunit of the RNA polymerase of influenza A/HongKong/156/97 (H5N1) influences promoter binding (2009), PLoS ONE, 4, e5473.
    View publication on PubMedView publication on EuropePMC

Organism

EC Number Organism UniProt Comment Textmining
2.7.7.48 influenza A virus
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 standard activity strains A/WSN/33, H1N1, and A/NT/60/68, H3N2, and increased activity strains A/HongKong/156/97, H5N1, and A/Vietnam/1194/04, H5N1
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Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.7.7.48 additional information
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 strains A/WSN/33, H1N1, and A/NT/60/68, H3N2, show standard RNA polymerase activity, while strains A/HongKong/156/97, H5N1, and A/Vietnam/1194/04, H5N1, show increased polymerase activity correlated with enhanced promoter binding. The N-terminal region of the PA subunit is the major determinant of this enhanced promoter activity influenza A virus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.7.48 additional information the heterotrimeric complex of PB1, PB2 and PA subunits cooperate in the transcription and replication of the viral genome, the N-terminal region of the PA subunit of two recent H5N1 strains can influence promoter binding and RNA polymerase activity as well as virulence of the strains, overview influenza A virus ?
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 ?

Subunits

EC Number Subunits Comment Organism
2.7.7.48 heterotrimer the RNA polymerase of influenza virus is a heterotrimeric complex of PB1, PB2 and PA subunits, which cooperate in the transcription and replication of the viral genome. The N-terminal region of the PA subunit of two recent H5N1 strains can influence promoter binding influenza A virus

Synonyms

EC Number Synonyms Comment Organism
2.7.7.48 RNA polymerase
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 influenza A virus

General Information

EC Number General Information Comment Organism
2.7.7.48 additional information the RNA polymerase of influenza virus is a heterotrimeric complex of PB1, PB2 and PA subunits, which cooperate in the transcription and replication of the viral genome influenza A virus