EC Number | Application | Comment | Organism |
---|---|---|---|
6.1.1.1 | medicine | dominant-intermediate Charcot-Marie-Tooth neuropathy, DI-CMT, is characterized by axonal degeneration and demyelination of peripheral motor and sensory neurons, three dominant mutations in the YARS gene, encoding tyrosyl-tRNA synthetase, have so far been associated with DI-CMT type C | Drosophila melanogaster |
6.1.1.1 | medicine | dominant-intermediate Charcot-Marie-Tooth neuropathy, DI-CMT, is characterized by axonal degeneration and demyelination of peripheral motor and sensory neurons, three dominant mutations in the YARS gene, encoding tyrosyl-tRNA synthetase, have so far been associated with DI-CMT type C | Homo sapiens |
EC Number | Cloned (Comment) | Organism |
---|---|---|
6.1.1.1 | - |
Homo sapiens |
6.1.1.1 | into the pUAST transformation vector | Drosophila melanogaster |
6.1.1.1 | into the single copy plasmid YCplac111 | Saccharomyces cerevisiae |
EC Number | Protein Variants | Comment | Organism |
---|---|---|---|
6.1.1.1 | TyrRS_153-156delVKQV | dominant-intermediate Charcot-Marie-Tooth neuropathy associated mutation | Homo sapiens |
6.1.1.1 | TyrRS_E196K | dominant-intermediate Charcot-Marie-Tooth neuropathy associated mutation | Homo sapiens |
6.1.1.1 | TyrRS_G41R | dominant-intermediate Charcot-Marie-Tooth neuropathy associated mutation | Homo sapiens |
6.1.1.1 | YARS_153-156delVKQV | dominant-intermediate Charcot-Marie-Tooth neuropathy associated mutation | Saccharomyces cerevisiae |
6.1.1.1 | YARS_E196K | dominant-intermediate Charcot-Marie-Tooth neuropathy associated mutation | Saccharomyces cerevisiae |
6.1.1.1 | YARS_G41R | dominant-intermediate Charcot-Marie-Tooth neuropathy associated mutation | Saccharomyces cerevisiae |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
6.1.1.1 | cytoplasm | - |
Drosophila melanogaster | 5737 | - |
6.1.1.1 | cytoplasm | - |
Homo sapiens | 5737 | - |
6.1.1.1 | cytoplasm | - |
Saccharomyces cerevisiae | 5737 | - |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
6.1.1.1 | ATP + L-tyrosine + tRNATyr | Drosophila melanogaster | - |
AMP + diphosphate + L-tyrosyl-tRNATyr | - |
? | |
6.1.1.1 | ATP + L-tyrosine + tRNATyr | Homo sapiens | - |
AMP + diphosphate + L-tyrosyl-tRNATyr | - |
? | |
6.1.1.1 | ATP + L-tyrosine + tRNATyr | Saccharomyces cerevisiae | - |
AMP + diphosphate + L-tyrosyl-tRNATyr | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
6.1.1.1 | Drosophila melanogaster | - |
a model for human dominant-intermediate Charcot-Marie-Tooth neuropathy type C is established | - |
6.1.1.1 | Homo sapiens | - |
- |
- |
6.1.1.1 | Saccharomyces cerevisiae | - |
- |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
6.1.1.1 | by utilizing the His-tag | Homo sapiens |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
6.1.1.1 | neuron | - |
Drosophila melanogaster | - |
6.1.1.1 | neuron | - |
Homo sapiens | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
6.1.1.1 | ATP + L-tyrosine + tRNATyr | - |
Drosophila melanogaster | AMP + diphosphate + L-tyrosyl-tRNATyr | - |
? | |
6.1.1.1 | ATP + L-tyrosine + tRNATyr | - |
Homo sapiens | AMP + diphosphate + L-tyrosyl-tRNATyr | - |
? | |
6.1.1.1 | ATP + L-tyrosine + tRNATyr | - |
Saccharomyces cerevisiae | AMP + diphosphate + L-tyrosyl-tRNATyr | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
6.1.1.1 | dTyRS | - |
Drosophila melanogaster |
6.1.1.1 | Tyrosyl-tRNA synthetase | - |
Drosophila melanogaster |
6.1.1.1 | Tyrosyl-tRNA synthetase | - |
Homo sapiens |
6.1.1.1 | Tyrosyl-tRNA synthetase | - |
Saccharomyces cerevisiae |
6.1.1.1 | TyrRS | - |
Drosophila melanogaster |
6.1.1.1 | TyrRS | - |
Homo sapiens |
6.1.1.1 | TyrRS | - |
Saccharomyces cerevisiae |
6.1.1.1 | TYS1 | - |
Saccharomyces cerevisiae |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
6.1.1.1 | ATP | - |
Drosophila melanogaster | |
6.1.1.1 | ATP | - |
Homo sapiens | |
6.1.1.1 | ATP | - |
Saccharomyces cerevisiae |