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Literature summary extracted from

  • Bhattacharya, S.; Mathew, G.; Jayne, D.G.; Pelengaris, S.; Khan, M.
    15-lipoxygenase-1 in colorectal cancer: a review (2009), Tumour Biol., 30, 185-199.
    View publication on PubMed

Application

EC Number Application Comment Organism
1.13.11.33 medicine 15-LOX-1 and its metabolites (13-S-hydroxyoctadecadienoic acid and 15-S-hydroxyeicosatetraenoic acid) have anti-carcinogenic effects in colorectal cancer. 15-LOX-1 is possibly of prognostic value in stage IV colon cancer survival Homo sapiens
1.13.11.33 medicine has anti-carcinogenic effects in colorectal cancer Mus musculus

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.13.11.33 HCT-116 and LoVo cells transfected with 15-LOX-1 vector Homo sapiens
1.13.11.33 transgenic mice models overexpressing 15-LOX in endothelial cells Mus musculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.13.11.33 anthraquinone
-
 Homo sapiens
1.13.11.33 baicalein
-
 Homo sapiens
1.13.11.33 caffeic acid specific inhibitor of 15-LOX-1 Homo sapiens
1.13.11.33 esculetin
-
 Homo sapiens
1.13.11.33 GATA-6 inhibits non-steroidal anti-inflammatory drugs-induced transcription of 15-LOX-1 in colorectal cancer cells Homo sapiens
1.13.11.33 additional information 15-LOX-1 can be inactivated by epigenetic silencing, hypermethylation of the CpG islands of the 15-LOX-1 promoter results in its reduced transcription in cancers, e.g. lymphomas, lung, prostate and cervix cancers. Brominated phenol esters are potent 15-LOX-1 inhibitors Homo sapiens
1.13.11.33 nor-dihydro-guaiaretic acid
-
 Homo sapiens
1.13.11.33 quercetin
-
 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.13.11.33 cytoplasm 15-LOX-1, in epithelial cells within the tumour and surrounding normal tissue Homo sapiens 5737
-
1.13.11.33 additional information 15-LOX-1, in the stroma of fibroblasts Homo sapiens
-
-

Organism

EC Number Organism UniProt Comment Textmining
1.13.11.33 Homo sapiens
-
-
-
1.13.11.33 Mus musculus
-
-
-
1.13.11.33 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.13.11.33 Caco-2 cell
-
 Homo sapiens
-
1.13.11.33 colon 15-LOX-1 but not 15-LOX-2 Homo sapiens
-
1.13.11.33 cornea 15-LOX-2 Homo sapiens
-
1.13.11.33 eosinophil 15-LOX-1 Homo sapiens
-
1.13.11.33 epithelium of the tracheobronchial tree, 15-LOX-1 Homo sapiens
-
1.13.11.33 fibroblast 15-LOX-1 Homo sapiens
-
1.13.11.33 IEC-6 cell
-
 Rattus norvegicus
-
1.13.11.33 lung 15-LOX-2 Homo sapiens
-
1.13.11.33 additional information 15-LOX-1 and -2 are preferentially expressed in normal tissue, present in HTB-38 cells Homo sapiens
-
1.13.11.33 additional information is preferentially expressed in normal tissue Mus musculus
-
1.13.11.33 prostate 15-LOX-2 Homo sapiens
-
1.13.11.33 reticulocyte 15-LOX-1 Homo sapiens
-
1.13.11.33 skin 15-LOX-1 and 15-LOX-2 Homo sapiens
-
1.13.11.33 SW-480 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.13.11.33 arachidonate + O2 both 15-LOX-1 and -2 Homo sapiens (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyicosa-5,8,11,13-tetraenoate
-
 ?
1.13.11.33 linoleic acid + O2 both 15-LOX-1, 15-LOX-2 reacts with linoleic acid poorly Homo sapiens 13-S-hydroxyoctadecadienoic acid
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.13.11.33 12/15-LOX
-
 Mus musculus
1.13.11.33 12/15-LOX
-
 Homo sapiens
1.13.11.33 15-lipoxygenase-1
-
 Homo sapiens
1.13.11.33 15-LOX-1
-
 Homo sapiens
1.13.11.33 15-LOX-1
-
 Rattus norvegicus
1.13.11.33 15-LOX-2
-
 Homo sapiens
1.13.11.33 Alox15
-
 Mus musculus
1.13.11.33 reticulocyte-type of 15-LOX-1
-
 Homo sapiens

Expression

EC Number Organism Comment Expression
1.13.11.33 Homo sapiens demethylation of DNA in some cell lines increases 15-LOX-1 expression. Increased levels of 15-LOX-1 are associated with downregulation of GATA-6 in Caco-2 colon cancer cells treated with sodium butyrate to induce cell differentiation and apoptosis. Activation of the cGMP-PKG system can induce the cellular expression of 15-LOX-1 in SW-480 colon cancer cells. 5-aza-2-deoxycytidine increases 15-LOX-1 expression. Interleukin-4 upregulates the 15-LOX-1 gene in HTB-38 and Caco-2 human colorectal cancer cell lines. Interleukin-13 upregulates the 15-LOX-1 gene in HTB-38 and Caco-2 human colorectal cancer cell lines up

General Information

EC Number General Information Comment Organism
1.13.11.33 metabolism shifting linoleic acid metabolism from 15-LOX-1 to COX-2 is procarcinogenic Homo sapiens
1.13.11.33 physiological function 15-LOX-1 promotes mitogenic response to epidermal growth factor in fibroblasts and NaBT-induced apoptosis in colon cancer cells. Non-steroidal anti-inflammatory drugs-induced apoptosis mediated by 15-LOX-1/GATA-6 in colon cancer Homo sapiens
1.13.11.33 physiological function inhibits tumour growth and metastasis. Enzyme promotes atherosclerosis and can inhibit growth and spread of lung (Lewis lung carcinoma model) and breast (mouse mammary adenocarcinoma model) cancer cells Mus musculus