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Literature summary extracted from

  • Kubo, I.; Ha, T.J.; Tsujimoto, K.; Tocoli, F.E.; Green, I.R.
    Evaluation of lipoxygenase inhibitory activity of anacardic acids (2008), Z. Naturforsch. C, 63, 539-546.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.13.11.12 2-dodecyl-6-hydroxybenzoic acid C12:0, competitive inhibitor Glycine max
1.13.11.12 2-hydroxy-6-[(8E)-pentadec-8-en-1-yl]benzoic acid C15:1, E-isomer, competitive inhibitor Glycine max
1.13.11.12 6-(2'-ethylheptyl)salicylic acid
-
 Glycine max
1.13.11.12 6-(4',8'-dimethylnonyl) salicylic acid
-
 Glycine max
1.13.11.12 6-pentadecanylsalicylic acid competitive inhibitor, dose-dependent inhibitory effect Glycine max
1.13.11.12 6-[2'-(2'',4'',5''-trihydroxyphenyl)etyl]salicylic acid inhibits lipoxygenase-catalyzed oxidation of linoleic acid, but to a lesser extent compared to 6-pentadecanylsalicylic acid Glycine max
1.13.11.12 6-[2'-(2'',4''-dihydroxyphenyl)ethyl]salicylic acid inhibits lipoxygenase-catalyzed oxidation of linoleic acid, but to a lesser extent compared to 6-pentadecanylsalicylic acid Glycine max
1.13.11.12 6-[2'-(2'',5''-dihydroxyphenyl)ethyl]salicylic acid inhibits lipoxygenase-catalyzed oxidation of linoleic acid, but to a lesser extent compared to 6-pentadecanylsalicylic acid Glycine max
1.13.11.12 6-[2'-(3'',4''-dihydroxyphenyl)ethyl]salicylic acid inhibits lipoxygenase-catalyzed oxidation of linoleic acid, but to a lesser extent compared to 6-pentadecanylsalicylic acid Glycine max
1.13.11.12 6-[8(Z),11(Z),14-pentadecatrienyl]salicylic acid from Anacardium occidentale Glycine max
1.13.11.12 6-[8(Z),11(Z)-pentadecadienyl]salicylic acid from Anacardium occidentale Glycine max
1.13.11.12 6-[8(Z)-pentadecenyl]salicylic acid from Anacardium occidentale Glycine max

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.13.11.12 0.0117
-
 linoleic acid in the presence of 2-hydroxy-6-[(8E)-pentadec-8-en-1-yl]benzoic acid Glycine max
1.13.11.12 0.0131
-
 linoleic acid in the presence of 6-pentadecanylsalicylic acid Glycine max
1.13.11.12 0.0132
-
 linoleic acid in the presence of 2-dodecyl-6-hydroxybenzoic acid Glycine max

Organism

EC Number Organism UniProt Comment Textmining
1.13.11.12 Glycine max
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.13.11.12 linoleic acid + O2
-
 Glycine max (9Z,11E)-(13S)-13-hydroperoxyoctadeca-9,11-dienoic acid
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.13.11.12 lipoxygenase-1
-
 Glycine max

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.13.11.12 9
-
-
 Glycine max

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.13.11.12 0.0028
-
 2-hydroxy-6-[(8E)-pentadec-8-en-1-yl]benzoic acid pH 9.0 Glycine max
1.13.11.12 0.0064
-
 6-pentadecanylsalicylic acid pH 9.0 Glycine max
1.13.11.12 0.0096
-
 2-dodecyl-6-hydroxybenzoic acid pH 9.0 Glycine max

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.13.11.12 0.00207
-
 pH 9.0 Glycine max 2-dodecyl-6-hydroxybenzoic acid
1.13.11.12 0.0068
-
 pH 9.0 Glycine max 2-hydroxy-6-[(8E)-pentadec-8-en-1-yl]benzoic acid
1.13.11.12 0.0105
-
 pH 9.0 Glycine max 6-(4',8'-dimethylnonyl) salicylic acid
1.13.11.12 0.0143
-
 pH 9.0 Glycine max 6-pentadecanylsalicylic acid
1.13.11.12 0.0188
-
 pH 9.0 Glycine max 6-(2'-ethylheptyl)salicylic acid
1.13.11.12 0.4
-
 pH 9.0 Glycine max 6-[2'-(2'',5''-dihydroxyphenyl)ethyl]salicylic acid