EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
3.1.3.4 | additional information | is N-ethylmaleimide insensitive | Homo sapiens |
EC Number | Cloned (Comment) | Organism |
---|---|---|
3.1.3.4 | LPP1, LPP2 and LPP3 | Homo sapiens |
EC Number | Protein Variants | Comment | Organism |
---|---|---|---|
3.1.3.4 | R127K/H223L | negligible LPP1 activity, although each mutant is still able to form oligomers | Homo sapiens |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
3.1.3.4 | membrane | LPPs are integral membrane proteins with six transmembrane domains | Homo sapiens | 16020 | - |
3.1.3.4 | additional information | LPP1 and LPP3 are present in caveolae, localised to distinct lipid rafts | Homo sapiens | - |
- |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
3.1.3.4 | additional information | is Mg2+ independent | Homo sapiens |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.1.3.4 | Drosophila melanogaster | - |
- |
- |
3.1.3.4 | Homo sapiens | - |
- |
- |
3.1.3.4 | Mus musculus | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
3.1.3.4 | central nervous system | - |
Drosophila melanogaster | - |
3.1.3.4 | embryonic fibroblast | - |
Mus musculus | - |
3.1.3.4 | posterior midgut | - |
Drosophila melanogaster | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.1.3.4 | ceramide 1-phosphate + H2O | - |
Homo sapiens | ceramide + phosphate | - |
? | |
3.1.3.4 | lysophosphatidic acid + H2O | - |
Homo sapiens | monoacylglycerol + phosphate | - |
? | |
3.1.3.4 | additional information | the catalytic site is arranged into three distinct domains: one substrate recognition site and two catalytic sites | Homo sapiens | ? | - |
? | |
3.1.3.4 | phosphatidic acid + H2O | - |
Homo sapiens | 1,2-diacyl-sn-glycerol + phosphate | - |
? | |
3.1.3.4 | sphingosine 1-phosphate + H2O | - |
Homo sapiens | sphingosine + phosphate | - |
? |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
3.1.3.4 | dimer | catalytic activity is required for dimerisation | Drosophila melanogaster |
3.1.3.4 | hexamer | - |
Homo sapiens |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
3.1.3.4 | lipid phosphate phosphatase | - |
Drosophila melanogaster |
3.1.3.4 | lipid phosphate phosphatase | - |
Mus musculus |
3.1.3.4 | lipid phosphate phosphatase | - |
Homo sapiens |
3.1.3.4 | LPP1 | - |
Mus musculus |
3.1.3.4 | LPP1 | - |
Homo sapiens |
3.1.3.4 | LPP2 | - |
Homo sapiens |
3.1.3.4 | LPP3 | - |
Homo sapiens |
3.1.3.4 | Wunen | - |
Drosophila melanogaster |
3.1.3.4 | wunen-2 | - |
Drosophila melanogaster |
EC Number | Organism | Comment | Expression |
---|---|---|---|
3.1.3.4 | Homo sapiens | epidermal growth factor increases LPP3 mRNA in HeLa cells. Androgen increases LPP1 mRNA in adenocarcinoma cells | up |
EC Number | General Information | Comment | Organism |
---|---|---|---|
3.1.3.4 | physiological function | physiologically relevant increases in LPP1 activity in mouse embryonic fibroblasts (isolated from transgenic mice with 20 gene copies of LPP1) reduces lysophosphatidic acid- and platelet-derived growth factor-activation of ERK-1/2 and migration, resulting from down-regulation of typical proteinkinase C isoform(s) which are required for regulation of cell migration | Mus musculus |
3.1.3.4 | physiological function | stable overexpression of LPP1 or LPP2 reduces sphingosine 1-phosphate, lysophosphatidic acid- and thrombin-induced activation of ERK-1/2 | Homo sapiens |
3.1.3.4 | physiological function | wunen generates a phospholipid gradient and thereby repels germ cells towards higher phospholipid levels and away from the midline. Wunen/wunen-2 also governs the death of mis-migrating germ cells and survival of pole cells which compete for a common phospholipid substrate with somatic cells | Drosophila melanogaster |