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Literature summary extracted from

  • Zhao, Y.; Yin, H.Q.; Yu, Q.T.; Qiao, Y.; Dai, H.Y.; Zhang, M.X.; Zhang, L.; Liu, Y.F.; Wang, L.C.; Liu, D.S.; Deng, B.P.; Zhang, Y.H.; Pang, C.M.; Song, H.D.; Qu, X.; Jiang, H.; Liu, C.X.; Lu, X.T.; Liu, B.; Gao, F.; Dong, B.
    ACE2 overexpression improves left ventricular remodeling and function in rats with myocardial infarction (2010), Hum. Gene Ther., 21, 1545-1554.
    View publication on PubMed

Application

EC Number Application Comment Organism
3.4.17.23 pharmacology ACE 2 is a potential therapeutic target in the treatment of heart failure Rattus norvegicus

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.17.23 cloning of the enzyme utilizing the murine cytomegalovirus immediate early gene promoter, MCMV Pr, in an adenoviral vector for ACE2 overexpression in rats as a gene therapy model. overview Rattus norvegicus

Protein Variants

EC Number Protein Variants Comment Organism
3.4.17.23 additional information overexpression of ACE2 favorably affects the pathological process of left ventricular remodeling after myocardial infarction by inhibiting ACE activity, reducing AngII levels and upregulating Ang(1-7) expression Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.17.23 cell membrane
-
 Rattus norvegicus
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.17.23 angiotensin II + H2O Rattus norvegicus
-
 angiotensin(1-7) + L-Phe
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.17.23 Rattus norvegicus
-
 male Wistar-Kyoto rats
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.17.23 blood vessel
-
 Rattus norvegicus
-
3.4.17.23 coronary artery vascular walls and endothelium Rattus norvegicus
-
3.4.17.23 endothelium and vascular walls of coronary arteries Rattus norvegicus
-
3.4.17.23 heart
-
 Rattus norvegicus
-
3.4.17.23 macrophage
-
 Rattus norvegicus
-
3.4.17.23 myocardium
-
 Rattus norvegicus
-
3.4.17.23 myocyte
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.17.23 angiotensin II + H2O
-
 Rattus norvegicus angiotensin(1-7) + L-Phe
-
 ?
3.4.17.23 angiotensin II + H2O i.e. Asp-Arg-Val-Tyr-Ile-His-Pro-Phe, detection of myocardial ACE2 activity by surface enhanced laser desorption lionization time of flight mass spectroscopy, SELDI-TOF-MS Rattus norvegicus angiotensin(1-7) + L-Phe i.e. Asp-Arg-Val-Tyr-Ile-His-Pro ?

Synonyms

EC Number Synonyms Comment Organism
3.4.17.23 ACE2
-
 Rattus norvegicus

General Information

EC Number General Information Comment Organism
3.4.17.23 physiological function angiotensin II is a critical factor for stimulating cardiocyte hypertrophy, fibroblast proliferation and extracellular matrix production in left ventricular remodeling. ACE2 overexpression attenuates left ventricular myocardial fibrosis and improves left ventricular remodeling and systolic function, overview Rattus norvegicus