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Literature summary extracted from

  • Xia, H.; Feng, Y.; Obr, T.D.; Hickman, P.J.; Lazartigues, E.
    Angiotensin II type 1 receptor-mediated reduction of angiotensin-converting enzyme 2 activity in the brain impairs baroreflex function in hypertensive mice (2009), Hypertension, 53, 210-216.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.4.17.23 losartan an angiotensin II type 1 receptor blocker, increases central ACE2 activity. Losartan also restores brain ACE2 activity in transgenic RA mice, overview Mus musculus
3.4.17.23 additional information no activation by PD123319, an angiotensin II type 2 antagonist Mus musculus

Protein Variants

EC Number Protein Variants Comment Organism
3.4.17.23 additional information generation of triple-transgenic-model mice with brain ACE2 overexpression on a chronically hypertensive, AngII-increased background. The transgenic mice show dramatically decreased baseline spontaneous baroreflex sensitivity and brain ACE2 activity compared with nontransgenic mice, whereas peripheral ACE2 activity/expression remains unaffected Mus musculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.17.23 additional information central angiotensin II type 1 receptors reduce ACE2 expression/activity in hypertensive mice Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.17.23 angiotensin II + H2O Mus musculus
-
 angiotensin(1-7) + L-Phe Ang(1-7) is a vasodilator peptide ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.17.23 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.17.23 brain
-
 Mus musculus
-
3.4.17.23 kidney
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.17.23 angiotensin II + H2O
-
 Mus musculus angiotensin(1-7) + L-Phe
-
 ?
3.4.17.23 angiotensin II + H2O
-
 Mus musculus angiotensin(1-7) + L-Phe Ang(1-7) is a vasodilator peptide ?

Synonyms

EC Number Synonyms Comment Organism
3.4.17.23 ACE2
-
 Mus musculus

Expression

EC Number Organism Comment Expression
3.4.17.23 Mus musculus central angiotensin II type 1 receptors reduce ACE2 expression/activity in hypertensive mice down

General Information

EC Number General Information Comment Organism
3.4.17.23 malfunction angiotensin II type 1 receptor-mediated reduction of angiotensin-converting enzyme 2 activity in the brain impairs baroreflex function in hypertensive mice Mus musculus
3.4.17.23 physiological function ACE2 is a component of the brain renin-angiotensin system participating in the central regulation of blood pressure Mus musculus