Literature summary extracted from

Fontenele, M.; Carneiro, K.; Agrellos, R.; Oliveira, D.; Oliveira-Silva, A.; Vieira, V.; Negreiros, E.; Machado, E.; Araujo H.
The Ca2+-dependent protease calpain A regulates cactus/I kappaB levels during Drosophila development in response to maternal Dpp signals (2009), Mech. Dev., 126, 737-751.

Localization

EC Number	Localization	Comment	Organism	GeneOntology No.	Textmining
3.4.22.B36	plasma membrane	-	Drosophila melanogaster	5886	-

Organism

EC Number	Organism	UniProt	Comment	Textmining
3.4.22.B36	Drosophila melanogaster	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
3.4.22.B36	embryo	-	Drosophila melanogaster	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
3.4.22.B36	N-succinyl-L-Leu-L-Tyr-7-amido-4-methylcoumarin + H2O	-	Drosophila melanogaster	N-succinyl-L-Leu-L-Tyr + 7-amino-4-methylcoumarin	-	?

Synonyms

EC Number	Synonyms	Comment	Organism
3.4.22.B36	CalpA	-	Drosophila melanogaster

General Information

EC Number	General Information	Comment	Organism
3.4.22.B36	malfunction	calpainA knockdowns increase Cactus levels, shifting the dorsal gradient and dorsal-ventral patterning. Decapentaplegic protein signals increase Cactus levels through calpain A inhibition, thereby interfering with Dorsal gene activation	Drosophila melanogaster
3.4.22.B36	physiological function	calpain A alters the size and position of Dorsal target gene expression domains, Cactus is regulated by calpain A, calpain A is regulated by Decapentaplegic signaling	Drosophila melanogaster

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Release 2023.1 (January 2023)