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Literature summary extracted from
- Modulation by salt intake of the vascular response mediated through adenosine A(2A) receptor: role of CYP epoxygenase and soluble epoxide hydrolase (2010), Am. J. Physiol. Regul. Integr. Comp. Physiol., 299, R325-R333.
Application
| EC Number | Application | Comment | Organism |
|---|---|---|---|
| 3.3.2.10 | medicine | modulation of the vascular response mediated through adenosine A2A receptor using aortas from mice fed a 4% NaCl high salt or 0.45% NaCl low salt diet for 4-5 weeks. Compared with NS, HS vessels show increased CYP2J2 and A2A adenosine receptor expression but decreased sEH, CYP4A, and A1 adenosine receptor expression. Data suggest that in mice fed low salt containing diet, upregulation of arterial A1 receptor causes vasoconstriction via increased sEH and CYP4A proteins. In mice fed high salt-containing diet, upregulation of A2A receptor protein triggers vascular relaxation through ATP-sensitive channels via upregulation of CYP2J2 enzyme | Mus musculus |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 1.14.14.1 | microsome | - |
Mus musculus | - |
- |
| 1.14.14.1 | microsome | - |
Homo sapiens | - |
- |
| 1.14.14.1 | microsome | - |
Rattus norvegicus | - |
- |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.14.14.1 | additional information | Mus musculus | CYP4A enzymes predominantly function as AA omega-hydroxylases, hydroxy metabolites are roduced by the individual CYP isoforms in a regio- and stereoselective manner. CYP isoforms that do not produce 20-hydroxyeicosatetraenoic acid but function predominantly as AA (omega-1)-hydroxylases include CYP1A1, but also act regioselective | ? | - |
? |  |
| 1.14.14.1 | additional information | Homo sapiens | CYP4A enzymes predominantly function as AA omega-hydroxylases, hydroxy metabolites are roduced by the individual CYP isoforms in a regio- and stereoselective manner. CYP isoforms that do not produce 20-hydroxyeicosatetraenoic acid but function predominantly as AA (omega-1)-hydroxylases include CYP1A1, but also act regioselective | ? | - |
? | |
| 1.14.14.1 | additional information | Rattus norvegicus | CYP4A enzymes predominantly function as AA omega-hydroxylases, hydroxy metabolites are roduced by the individual CYP isoforms in a regio- and stereoselective manner. CYP isoforms that do not produce 20-hydroxyeicosatetraenoic acid but function predominantly as AA (omega-1)-hydroxylases include CYP1A1, but also act regioselective | ? | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.14.14.1 | Homo sapiens | - |
CYP4A11 | - |
| 1.14.14.1 | Mus musculus | - |
isozyme Cyp4a12 | - |
| 1.14.14.1 | Rattus norvegicus | - |
isozyme CYP4A1 | - |
| 3.3.2.10 | Mus musculus | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.14.14.1 | kidney | - |
Mus musculus | - |
| 1.14.14.1 | kidney | - |
Homo sapiens | - |
| 1.14.14.1 | kidney | - |
Rattus norvegicus | - |
| 1.14.14.1 | liver | - |
Mus musculus | - |
| 1.14.14.1 | liver | - |
Homo sapiens | - |
| 1.14.14.1 | liver | - |
Rattus norvegicus | - |
| 3.3.2.10 | aorta | - |
Mus musculus | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.14.14.1 | adrenic acid + [reduced NADPH-hemoprotein reductase] + O2 | i.e. all-cis-7,10,13,16-docosatetraenoic acid | Mus musculus | ? | - |
? | |
| 1.14.14.1 | adrenic acid + [reduced NADPH-hemoprotein reductase] + O2 | i.e. all-cis-7,10,13,16-docosatetraenoic acid | Homo sapiens | ? | - |
? | |
| 1.14.14.1 | adrenic acid + [reduced NADPH-hemoprotein reductase] + O2 | i.e. all-cis-7,10,13,16-docosatetraenoic acid | Rattus norvegicus | ? | - |
? | |
| 1.14.14.1 | arachidonic acid + [reduced NADPH-hemoprotein reductase] + O2 | - |
Mus musculus | ? | - |
? | |
| 1.14.14.1 | arachidonic acid + [reduced NADPH-hemoprotein reductase] + O2 | - |
Homo sapiens | ? | - |
? | |
| 1.14.14.1 | arachidonic acid + [reduced NADPH-hemoprotein reductase] + O2 | - |
Rattus norvegicus | 20-hydroxyeicosatetraenoic acid + 19-hydroxyeicosatetraenoic acid + [oxidized NADPH-hemoprotein reductase] + H2O | ratio 12:1 | ? | |
| 1.14.14.1 | docosahexaenoic acid + [reduced NADPH-hemoprotein reductase] + O2 | - |
Mus musculus | 22-hydroxydocosahexaenoic acid + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
| 1.14.14.1 | docosahexaenoic acid + [reduced NADPH-hemoprotein reductase] + O2 | - |
Homo sapiens | 22-hydroxydocosahexaenoic acid + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
| 1.14.14.1 | docosahexaenoic acid + [reduced NADPH-hemoprotein reductase] + O2 | - |
Rattus norvegicus | 22-hydroxydocosahexaenoic acid + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
| 1.14.14.1 | eicosapentaenoic acid + NADPH + H+ + O2 | - |
Homo sapiens | 20-hydroxyeicosapentaenoic acid + NADP+ + H2O | - |
? | |
| 1.14.14.1 | eicosapentaenoic acid + [reduced NADPH-hemoprotein reductase] + O2 | - |
Rattus norvegicus | 20-hydroxyeicosapentaenoic acid + 19-hydroxyeicosapentaenoic acid + [oxidized NADPH-hemoprotein reductase] + H2O | ratio 4:3 | ? | |
| 1.14.14.1 | eicosapentaenoic acid + [reduced NADPH-hemoprotein reductase] + O2 | - |
Mus musculus | 20-hydroxyeicosapentaenoic acid + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
| 1.14.14.1 | linoleic acid + [reduced NADPH-hemoprotein reductase] + O2 | - |
Mus musculus | (9Z,12Z)-18-hydroxyoctadeca-9,12-dienoic acid + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
| 1.14.14.1 | linoleic acid + [reduced NADPH-hemoprotein reductase] + O2 | - |
Homo sapiens | (9Z,12Z)-18-hydroxyoctadeca-9,12-dienoic acid + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
| 1.14.14.1 | linoleic acid + [reduced NADPH-hemoprotein reductase] + O2 | - |
Rattus norvegicus | (9Z,12Z)-18-hydroxyoctadeca-9,12-dienoic acid + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
| 1.14.14.1 | additional information | CYP4A enzymes predominantly function as AA omega-hydroxylases, hydroxy metabolites are roduced by the individual CYP isoforms in a regio- and stereoselective manner. CYP isoforms that do not produce 20-hydroxyeicosatetraenoic acid but function predominantly as AA (omega-1)-hydroxylases include CYP1A1, but also act regioselective | Mus musculus | ? | - |
? | |
| 1.14.14.1 | additional information | CYP4A enzymes predominantly function as AA omega-hydroxylases, hydroxy metabolites are roduced by the individual CYP isoforms in a regio- and stereoselective manner. CYP isoforms that do not produce 20-hydroxyeicosatetraenoic acid but function predominantly as AA (omega-1)-hydroxylases include CYP1A1, but also act regioselective | Homo sapiens | ? | - |
? | |
| 1.14.14.1 | additional information | CYP4A enzymes predominantly function as AA omega-hydroxylases, hydroxy metabolites are roduced by the individual CYP isoforms in a regio- and stereoselective manner. CYP isoforms that do not produce 20-hydroxyeicosatetraenoic acid but function predominantly as AA (omega-1)-hydroxylases include CYP1A1, but also act regioselective | Rattus norvegicus | ? | - |
? | |
| 1.14.14.1 | additional information | the enzyme shows (omega-1)-hydroxylase activity against arachidonic acid, linoleic acid, and especially against eicosapentaenoic acid and docosahexaenoic acid, substrate specificities of isozymes, overview | Mus musculus | ? | - |
? | |
| 1.14.14.1 | additional information | the enzyme shows (omega-1)-hydroxylase activity against arachidonic acid, linoleic acid, and especially against eicosapentaenoic acid and docosahexaenoic acid, substrate specificities of isozymes, overview | Homo sapiens | ? | - |
? | |
| 1.14.14.1 | additional information | the enzyme shows (omega-1)-hydroxylase activity against arachidonic acid, linoleic acid, and especially against eicosapentaenoic acid and docosahexaenoic acid, substrate specificities of isozymes, overview | Rattus norvegicus | ? | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.14.14.1 | AA omega-hydroxylase | - |
Mus musculus |
| 1.14.14.1 | AA omega-hydroxylase | - |
Homo sapiens |
| 1.14.14.1 | AA omega-hydroxylase | - |
Rattus norvegicus |
| 1.14.14.1 | CYP4F2 | - |
Mus musculus |
| 1.14.14.1 | CYP4F3A | - |
Mus musculus |
| 1.14.14.1 | CYP4F3B | - |
Mus musculus |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.14.14.1 | NADPH | - |
Mus musculus | |
| 1.14.14.1 | NADPH | - |
Homo sapiens | |
| 1.14.14.1 | NADPH | - |
Rattus norvegicus | |
General Information
| EC Number | General Information | Comment | Organism |
|---|---|---|---|
| 1.14.14.1 | metabolism | cytochrome P450-dependent metabolism of omega-6 polyunsaturated fatty acids, overview | Mus musculus |
| 1.14.14.1 | metabolism | cytochrome P450-dependent metabolism of omega-6 polyunsaturated fatty acids, overview | Homo sapiens |
| 1.14.14.1 | metabolism | cytochrome P450-dependent metabolism of omega-6 polyunsaturated fatty acids, overview | Rattus norvegicus |
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Release 2023.1 (January 2023)
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