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Literature summary extracted from

  • Guo, Y.J.; Pan, Z.Z.; Chen, C.Q.; Hu, Y.H.; Liu, F.J.; Shi, Y.; Yan, J.H.; Chen, Q.X.
    Inhibitory effects of fatty acids on the activity of mushroom tyrosinase (2010), Appl. Biochem. Biotechnol., 162, 1564-1573.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.18.1 (2E)-but-2-enoic acid non-competitive inhibition Agaricus bisporus
1.14.18.1 (2E,4E)-hexa-2,4-dienoic acid non-competitive inhibition Agaricus bisporus
1.14.18.1 4-chlorosalicylic acid
-
Agaricus bisporus
1.14.18.1 alpha-cyano-4-hydroxycinnamic acid
-
Agaricus bisporus
1.14.18.1 azelaic acid
-
Agaricus bisporus
1.14.18.1 cefazolin
-
Agaricus bisporus
1.14.18.1 cefodizime
-
Agaricus bisporus
1.14.18.1 hexanoic acid mixed-type inhibition Agaricus bisporus
1.14.18.1 kojic acid
-
Agaricus bisporus
1.14.18.1 additional information not inhibited by butyric acid Agaricus bisporus
1.14.18.1 octanoic acid mixed-type inhibition Agaricus bisporus
1.14.18.1 phloridzin dihydrate
-
Agaricus bisporus
1.14.18.1 tropolone
-
Agaricus bisporus

Organism

EC Number Organism UniProt Comment Textmining
1.14.18.1 Agaricus bisporus
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.18.1 L-DOPA + O2 monophenolase activity Agaricus bisporus dopaquinone + H2O
-
?
1.14.18.1 L-Tyr + O2 diphenolase activity Agaricus bisporus L-Dopa + H2O
-
?

Synonyms

EC Number Synonyms Comment Organism
1.14.18.1 tyrosinase
-
Agaricus bisporus

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.14.18.1 0.91
-
(2E,4E)-hexa-2,4-dienoic acid in 50 mM Na2HPO4-NaH2PO4 buffer (pH 6.8), at 30°C Agaricus bisporus
1.14.18.1 1.54
-
octanoic acid in 50 mM Na2HPO4-NaH2PO4 buffer (pH 6.8), at 30°C Agaricus bisporus
1.14.18.1 2.51
-
hexanoic acid in 50 mM Na2HPO4-NaH2PO4 buffer (pH 6.8), at 30°C Agaricus bisporus
1.14.18.1 12
-
(2E)-but-2-enoic acid in 50 mM Na2HPO4-NaH2PO4 buffer (pH 6.8), at 30°C Agaricus bisporus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.14.18.1 0.9
-
value for inhibition of diphenolase activity, in 50 mM Na2HPO4-NaH2PO4 buffer (pH 6.8), at 30°C Agaricus bisporus (2E,4E)-hexa-2,4-dienoic acid
1.14.18.1 2.15
-
value for inhibition of diphenolase activity, in 50 mM Na2HPO4-NaH2PO4 buffer (pH 6.8), at 30°C Agaricus bisporus octanoic acid
1.14.18.1 3.06
-
value for inhibition of monophenolase activity, in 50 mM Na2HPO4-NaH2PO4 buffer (pH 6.8), at 30°C Agaricus bisporus octanoic acid
1.14.18.1 3.35
-
value for inhibition of diphenolase activity, in 50 mM Na2HPO4-NaH2PO4 buffer (pH 6.8), at 30°C Agaricus bisporus hexanoic acid
1.14.18.1 4.95
-
value for inhibition of monophenolase activity, in 50 mM Na2HPO4-NaH2PO4 buffer (pH 6.8), at 30°C Agaricus bisporus (2E,4E)-hexa-2,4-dienoic acid
1.14.18.1 12.05
-
value for inhibition of diphenolase activity, in 50 mM Na2HPO4-NaH2PO4 buffer (pH 6.8), at 30°C Agaricus bisporus (2E)-but-2-enoic acid
1.14.18.1 13.2
-
value for inhibition of monophenolase activity, in 50 mM Na2HPO4-NaH2PO4 buffer (pH 6.8), at 30°C Agaricus bisporus hexanoic acid
1.14.18.1 20
-
value for inhibition of monophenolase activity, in 50 mM Na2HPO4-NaH2PO4 buffer (pH 6.8), at 30°C Agaricus bisporus (2E)-but-2-enoic acid

General Information

EC Number General Information Comment Organism
1.14.18.1 physiological function tyrosinase is a key enzyme in the melanin biosynthesis Agaricus bisporus