EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.14.18.1 | (2E)-but-2-enoic acid | non-competitive inhibition | Agaricus bisporus | |
1.14.18.1 | (2E,4E)-hexa-2,4-dienoic acid | non-competitive inhibition | Agaricus bisporus | |
1.14.18.1 | 4-chlorosalicylic acid | - |
Agaricus bisporus | |
1.14.18.1 | alpha-cyano-4-hydroxycinnamic acid | - |
Agaricus bisporus | |
1.14.18.1 | azelaic acid | - |
Agaricus bisporus | |
1.14.18.1 | cefazolin | - |
Agaricus bisporus | |
1.14.18.1 | cefodizime | - |
Agaricus bisporus | |
1.14.18.1 | hexanoic acid | mixed-type inhibition | Agaricus bisporus | |
1.14.18.1 | kojic acid | - |
Agaricus bisporus | |
1.14.18.1 | additional information | not inhibited by butyric acid | Agaricus bisporus | |
1.14.18.1 | octanoic acid | mixed-type inhibition | Agaricus bisporus | |
1.14.18.1 | phloridzin dihydrate | - |
Agaricus bisporus | |
1.14.18.1 | tropolone | - |
Agaricus bisporus |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.14.18.1 | Agaricus bisporus | - |
- |
- |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.14.18.1 | L-DOPA + O2 | monophenolase activity | Agaricus bisporus | dopaquinone + H2O | - |
? | |
1.14.18.1 | L-Tyr + O2 | diphenolase activity | Agaricus bisporus | L-Dopa + H2O | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.14.18.1 | tyrosinase | - |
Agaricus bisporus |
EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.14.18.1 | 0.91 | - |
(2E,4E)-hexa-2,4-dienoic acid | in 50 mM Na2HPO4-NaH2PO4 buffer (pH 6.8), at 30°C | Agaricus bisporus | |
1.14.18.1 | 1.54 | - |
octanoic acid | in 50 mM Na2HPO4-NaH2PO4 buffer (pH 6.8), at 30°C | Agaricus bisporus | |
1.14.18.1 | 2.51 | - |
hexanoic acid | in 50 mM Na2HPO4-NaH2PO4 buffer (pH 6.8), at 30°C | Agaricus bisporus | |
1.14.18.1 | 12 | - |
(2E)-but-2-enoic acid | in 50 mM Na2HPO4-NaH2PO4 buffer (pH 6.8), at 30°C | Agaricus bisporus |
EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|---|
1.14.18.1 | 0.9 | - |
value for inhibition of diphenolase activity, in 50 mM Na2HPO4-NaH2PO4 buffer (pH 6.8), at 30°C | Agaricus bisporus | (2E,4E)-hexa-2,4-dienoic acid | |
1.14.18.1 | 2.15 | - |
value for inhibition of diphenolase activity, in 50 mM Na2HPO4-NaH2PO4 buffer (pH 6.8), at 30°C | Agaricus bisporus | octanoic acid | |
1.14.18.1 | 3.06 | - |
value for inhibition of monophenolase activity, in 50 mM Na2HPO4-NaH2PO4 buffer (pH 6.8), at 30°C | Agaricus bisporus | octanoic acid | |
1.14.18.1 | 3.35 | - |
value for inhibition of diphenolase activity, in 50 mM Na2HPO4-NaH2PO4 buffer (pH 6.8), at 30°C | Agaricus bisporus | hexanoic acid | |
1.14.18.1 | 4.95 | - |
value for inhibition of monophenolase activity, in 50 mM Na2HPO4-NaH2PO4 buffer (pH 6.8), at 30°C | Agaricus bisporus | (2E,4E)-hexa-2,4-dienoic acid | |
1.14.18.1 | 12.05 | - |
value for inhibition of diphenolase activity, in 50 mM Na2HPO4-NaH2PO4 buffer (pH 6.8), at 30°C | Agaricus bisporus | (2E)-but-2-enoic acid | |
1.14.18.1 | 13.2 | - |
value for inhibition of monophenolase activity, in 50 mM Na2HPO4-NaH2PO4 buffer (pH 6.8), at 30°C | Agaricus bisporus | hexanoic acid | |
1.14.18.1 | 20 | - |
value for inhibition of monophenolase activity, in 50 mM Na2HPO4-NaH2PO4 buffer (pH 6.8), at 30°C | Agaricus bisporus | (2E)-but-2-enoic acid |
EC Number | General Information | Comment | Organism |
---|---|---|---|
1.14.18.1 | physiological function | tyrosinase is a key enzyme in the melanin biosynthesis | Agaricus bisporus |