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Literature summary extracted from

  • Alber, B.E.
    Biotechnological potential of the ethylmalonyl-CoA pathway (2010), Appl. Microbiol. Biotechnol., 89, 17-25.
    View publication on PubMed

Organism

EC Number Organism UniProt Comment Textmining
1.3.1.85 Cereibacter sphaeroides
-
-
-
1.3.1.85 Methylorubrum extorquens
-
-
-
1.3.1.85 Streptomyces coelicolor
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.1.85 crotonyl-CoA + CO2 + NADPH + H+
-
 Cereibacter sphaeroides (2S)-ethylmalonyl-CoA + NADP+
-
 r
1.3.1.85 crotonyl-CoA + CO2 + NADPH + H+
-
 Streptomyces coelicolor (2S)-ethylmalonyl-CoA + NADP+
-
 r
1.3.1.85 crotonyl-CoA + CO2 + NADPH + H+
-
 Methylorubrum extorquens (2S)-ethylmalonyl-CoA + NADP+
-
 r
1.3.1.85 additional information the enzyme also catalyzes the reduction of crotonyl-CoA to butyryl-CoA in the absence of CO2, but with only about one tenth of the maximum rate Cereibacter sphaeroides ?
-
 ?
1.3.1.85 additional information the enzyme also catalyzes the reduction of crotonyl-CoA to butyryl-CoA in the absence of CO2, but with only about one tenth of the maximum rate Streptomyces coelicolor ?
-
 ?
1.3.1.85 additional information the enzyme also catalyzes the reduction of crotonyl-CoA to butyryl-CoA in the absence of CO2, but with only about one tenth of the maximum rate Methylorubrum extorquens ?
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
1.3.1.85 NADP+
-
 Cereibacter sphaeroides
1.3.1.85 NADP+
-
 Streptomyces coelicolor
1.3.1.85 NADP+
-
 Methylorubrum extorquens
1.3.1.85 NADPH
-
 Cereibacter sphaeroides
1.3.1.85 NADPH
-
 Streptomyces coelicolor
1.3.1.85 NADPH
-
 Methylorubrum extorquens

Expression

EC Number Organism Comment Expression
1.3.1.85 Cereibacter sphaeroides although the reaction is reversible, the activity of crotonyl-CoA carboxylase/reductase is up-regulated at least 60fold for Rhodobacter sphaeroides during growth with acetate versus succinate up
1.3.1.85 Streptomyces coelicolor although the reaction is reversible, the activity of crotonyl-CoA carboxylase/reductase is up-regulated at least 60fold for Rhodobacter sphaeroides during growth with acetate versus succinate up
1.3.1.85 Methylorubrum extorquens although the reaction is reversible, the activity of crotonyl-CoA carboxylase/reductase is up-regulated at least 60fold for Rhodobacter sphaeroides during growth with acetate versus succinate up

General Information

EC Number General Information Comment Organism
1.3.1.85 metabolism the unique reductive carboxylation of crotonyl-CoA by the enzyme crotonyl-CoA carboxylase/reductase can be considered the committed step for acetyl-CoA assimilation by the ethylmalonyl-CoA pathway Cereibacter sphaeroides
1.3.1.85 metabolism the unique reductive carboxylation of crotonyl-CoA by the enzyme crotonyl-CoA carboxylase/reductase can be considered the committed step for acetyl-CoA assimilation by the ethylmalonyl-CoA pathway Streptomyces coelicolor
1.3.1.85 metabolism the unique reductive carboxylation of crotonyl-CoA by the enzyme crotonyl-CoA carboxylase/reductase can be considered the committed step for acetyl-CoA assimilation by the ethylmalonyl-CoA pathway Methylorubrum extorquens