EC Number | Protein Variants | Comment | Organism |
---|---|---|---|
1.1.1.42 | R132C | naturally occuring mutation of IDH1 in melanoma metastasis of the lung | Homo sapiens |
1.1.1.42 | R132X | naturally occuring mutation of IDH1 in metastatic brain tumors | Homo sapiens |
1.1.1.42 | R172X | naturally occuring mutations of IDH2 in metastatic brain tumors | Homo sapiens |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.1.1.42 | isocitrate + NADP+ | Homo sapiens | - |
2-oxoglutarate + NADPH + H+ + CO2 | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.1.1.42 | Homo sapiens | O75874 | IDH1 | - |
1.1.1.42 | Homo sapiens | P48735 | IDH2 | - |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
1.1.1.42 | glioma cell | progressive gliomas | Homo sapiens | - |
1.1.1.42 | melanoma cell | - |
Homo sapiens | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.1.1.42 | isocitrate + NADP+ | - |
Homo sapiens | 2-oxoglutarate + NADPH + H+ + CO2 | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.1.1.42 | IDH1 | - |
Homo sapiens |
1.1.1.42 | IDH2 | - |
Homo sapiens |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
1.1.1.42 | NADP+ | - |
Homo sapiens |
EC Number | General Information | Comment | Organism |
---|---|---|---|
1.1.1.42 | physiological function | elective pressures in the brain environment may specifically favor the cell growth or survival of tumor cells with mutations in IDH1, regardless of primary tumor site | Homo sapiens |
1.1.1.42 | physiological function | elective pressures in the brain environment may specifically favor the cell growth or survival of tumor cells with mutations in IDH2, regardless of primary tumor site | Homo sapiens |