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Literature summary extracted from

  • Lopez, G.Y.; Reitman, Z.J.; Solomon, D.; Waldman, T.; Bigner, D.D.; McLendon, R.E.; Rosenberg, S.A.; Samuels, Y.; Yan, H.
    IDH1(R132) mutation identified in one human melanoma metastasis, but not correlated with metastases to the brain (2010), Biochem. Biophys. Res. Commun., 398, 585-587.
    View publication on PubMedView publication on EuropePMC

Protein Variants

EC Number Protein Variants Comment Organism
1.1.1.42 R132C naturally occuring mutation of IDH1 in melanoma metastasis of the lung Homo sapiens
1.1.1.42 R132X naturally occuring mutation of IDH1 in metastatic brain tumors Homo sapiens
1.1.1.42 R172X naturally occuring mutations of IDH2 in metastatic brain tumors Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.42 isocitrate + NADP+ Homo sapiens
-
2-oxoglutarate + NADPH + H+ + CO2
-
?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.42 Homo sapiens O75874 IDH1
-
1.1.1.42 Homo sapiens P48735 IDH2
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.42 glioma cell progressive gliomas Homo sapiens
-
1.1.1.42 melanoma cell
-
Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.42 isocitrate + NADP+
-
Homo sapiens 2-oxoglutarate + NADPH + H+ + CO2
-
?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.42 IDH1
-
Homo sapiens
1.1.1.42 IDH2
-
Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.42 NADP+
-
Homo sapiens

General Information

EC Number General Information Comment Organism
1.1.1.42 physiological function elective pressures in the brain environment may specifically favor the cell growth or survival of tumor cells with mutations in IDH1, regardless of primary tumor site Homo sapiens
1.1.1.42 physiological function elective pressures in the brain environment may specifically favor the cell growth or survival of tumor cells with mutations in IDH2, regardless of primary tumor site Homo sapiens