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Literature summary extracted from

  • Verkhovsky, M.I.; Bogachev, A.V.
    Sodium-translocating NADH:quinone oxidoreductase as a redox-driven ion pump (2010), Biochim. Biophys. Acta, 1797, 738-746.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
7.2.1.1 2-n-heptyl-4-hydroxyquinoline-N-oxide
-
Haemophilus influenzae
7.2.1.1 2-n-heptyl-4-hydroxyquinoline-N-oxide
-
Klebsiella pneumoniae
7.2.1.1 2-n-heptyl-4-hydroxyquinoline-N-oxide
-
Neisseria gonorrhoeae
7.2.1.1 2-n-heptyl-4-hydroxyquinoline-N-oxide
-
Neisseria meningitidis
7.2.1.1 2-n-heptyl-4-hydroxyquinoline-N-oxide
-
Porphyromonas gingivalis
7.2.1.1 2-n-heptyl-4-hydroxyquinoline-N-oxide
-
Pseudomonas aeruginosa
7.2.1.1 2-n-heptyl-4-hydroxyquinoline-N-oxide
-
Vibrio alginolyticus
7.2.1.1 2-n-heptyl-4-hydroxyquinoline-N-oxide
-
Vibrio cholerae serotype O1
7.2.1.1 2-n-heptyl-4-hydroxyquinoline-N-oxide
-
Vibrio harveyi
7.2.1.1 2-n-heptyl-4-hydroxyquinoline-N-oxide
-
Yersinia pestis
7.2.1.1 Ag+
-
Azotobacter vinelandii
7.2.1.1 Ag+
-
Haemophilus influenzae
7.2.1.1 Ag+
-
Neisseria gonorrhoeae
7.2.1.1 Ag+
-
Neisseria meningitidis
7.2.1.1 Ag+
-
Porphyromonas gingivalis
7.2.1.1 Ag+
-
Pseudomonas aeruginosa
7.2.1.1 Ag+
-
Vibrio alginolyticus
7.2.1.1 Ag+
-
Vibrio cholerae serotype O1
7.2.1.1 Ag+
-
Vibrio harveyi
7.2.1.1 Ag+
-
Yersinia pestis
7.2.1.1 Cd2+
-
Azotobacter vinelandii
7.2.1.1 Cd2+
-
Haemophilus influenzae
7.2.1.1 Cd2+
-
Klebsiella pneumoniae
7.2.1.1 Cd2+
-
Neisseria gonorrhoeae
7.2.1.1 Cd2+
-
Neisseria meningitidis
7.2.1.1 Cd2+
-
Porphyromonas gingivalis
7.2.1.1 Cd2+
-
Pseudomonas aeruginosa
7.2.1.1 Cd2+
-
Vibrio alginolyticus
7.2.1.1 Cd2+
-
Vibrio cholerae serotype O1
7.2.1.1 Cd2+
-
Vibrio harveyi
7.2.1.1 Cd2+
-
Yersinia pestis
7.2.1.1 Cu2+
-
Azotobacter vinelandii
7.2.1.1 Cu2+
-
Haemophilus influenzae
7.2.1.1 Cu2+
-
Klebsiella pneumoniae
7.2.1.1 Cu2+
-
Neisseria gonorrhoeae
7.2.1.1 Cu2+
-
Neisseria meningitidis
7.2.1.1 Cu2+
-
Porphyromonas gingivalis
7.2.1.1 Cu2+
-
Pseudomonas aeruginosa
7.2.1.1 Cu2+
-
Vibrio alginolyticus
7.2.1.1 Cu2+
-
Vibrio cholerae serotype O1
7.2.1.1 Cu2+
-
Vibrio harveyi
7.2.1.1 Cu2+
-
Yersinia pestis
7.2.1.1 korormicin specifically inhibits Na+-NQR at the level of its interaction with ubiquinone Azotobacter vinelandii
7.2.1.1 korormicin specifically inhibits Na+-NQR at the level of its interaction with ubiquinone Klebsiella pneumoniae
7.2.1.1 korormicin specifically inhibits Na+-NQR at the level of its interaction with ubiquinone Neisseria gonorrhoeae
7.2.1.1 korormicin specifically inhibits Na+-NQR at the level of its interaction with ubiquinone Neisseria meningitidis
7.2.1.1 korormicin specifically inhibits Na+-NQR at the level of its interaction with ubiquinone Porphyromonas gingivalis
7.2.1.1 korormicin specifically inhibits Na+-NQR at the level of its interaction with ubiquinone Pseudomonas aeruginosa
7.2.1.1 korormicin specifically inhibits Na+-NQR at the level of its interaction with ubiquinone Vibrio alginolyticus
7.2.1.1 korormicin specifically inhibits Na+-NQR at the level of its interaction with ubiquinone Vibrio cholerae serotype O1
7.2.1.1 korormicin specifically inhibits Na+-NQR at the level of its interaction with ubiquinone Vibrio harveyi
7.2.1.1 korormicin specifically inhibits Na+-NQR at the level of its interaction with ubiquinone Yersinia pestis
7.2.1.1 additional information Na+-NQR from Azotobacter vinelandii is not sensitive to low 2-n-heptyl-4-hydroxyquinoline-N-oxide concentrations Azotobacter vinelandii
7.2.1.1 additional information korormicin has no effect on the enzyme from Haemophilus influenza Haemophilus influenzae
7.2.1.1 additional information Na+-NQR from Klebsiella pneumoniae is fully resistant to either Ag+ or N-ethylmaleimide Klebsiella pneumoniae
7.2.1.1 N-ethylmaleimide
-
Azotobacter vinelandii
7.2.1.1 N-ethylmaleimide
-
Haemophilus influenzae
7.2.1.1 N-ethylmaleimide
-
Neisseria gonorrhoeae
7.2.1.1 N-ethylmaleimide
-
Neisseria meningitidis
7.2.1.1 N-ethylmaleimide
-
Porphyromonas gingivalis
7.2.1.1 N-ethylmaleimide
-
Pseudomonas aeruginosa
7.2.1.1 N-ethylmaleimide
-
Vibrio alginolyticus
7.2.1.1 N-ethylmaleimide
-
Vibrio cholerae serotype O1
7.2.1.1 N-ethylmaleimide
-
Vibrio harveyi
7.2.1.1 N-ethylmaleimide
-
Yersinia pestis
7.2.1.1 Pb2+
-
Azotobacter vinelandii
7.2.1.1 Pb2+
-
Haemophilus influenzae
7.2.1.1 Pb2+
-
Klebsiella pneumoniae
7.2.1.1 Pb2+
-
Neisseria gonorrhoeae
7.2.1.1 Pb2+
-
Neisseria meningitidis
7.2.1.1 Pb2+
-
Porphyromonas gingivalis
7.2.1.1 Pb2+
-
Pseudomonas aeruginosa
7.2.1.1 Pb2+
-
Vibrio alginolyticus
7.2.1.1 Pb2+
-
Vibrio cholerae serotype O1
7.2.1.1 Pb2+
-
Vibrio harveyi
7.2.1.1 Pb2+
-
Yersinia pestis
7.2.1.1 Zn2+
-
Azotobacter vinelandii
7.2.1.1 Zn2+
-
Haemophilus influenzae
7.2.1.1 Zn2+
-
Klebsiella pneumoniae
7.2.1.1 Zn2+
-
Neisseria gonorrhoeae
7.2.1.1 Zn2+
-
Neisseria meningitidis
7.2.1.1 Zn2+
-
Porphyromonas gingivalis
7.2.1.1 Zn2+
-
Pseudomonas aeruginosa
7.2.1.1 Zn2+
-
Vibrio alginolyticus
7.2.1.1 Zn2+
-
Vibrio cholerae serotype O1
7.2.1.1 Zn2+
-
Vibrio harveyi
7.2.1.1 Zn2+
-
Yersinia pestis

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
7.2.1.1 Na+ specific requirement for sodium ions, even in the absence of sodium ions Na+-NQR is unable to translocate protons Haemophilus influenzae
7.2.1.1 Na+ specific requirement for sodium ions, even in the absence of sodium ions Na+-NQR is unable to translocate protons Vibrio harveyi
7.2.1.1 Na+ specific requirement for sodium ions, even in the absence of sodium ions Na+-NQR is unable to translocate protons Pseudomonas aeruginosa
7.2.1.1 Na+ specific requirement for sodium ions, even in the absence of sodium ions Na+-NQR is unable to translocate protons Neisseria gonorrhoeae
7.2.1.1 Na+ specific requirement for sodium ions, even in the absence of sodium ions Na+-NQR is unable to translocate protons Neisseria meningitidis
7.2.1.1 Na+ specific requirement for sodium ions, even in the absence of sodium ions Na+-NQR is unable to translocate protons Klebsiella pneumoniae
7.2.1.1 Na+ specific requirement for sodium ions, even in the absence of sodium ions Na+-NQR is unable to translocate protons Azotobacter vinelandii
7.2.1.1 Na+ specific requirement for sodium ions, even in the absence of sodium ions Na+-NQR is unable to translocate protons Yersinia pestis
7.2.1.1 Na+ specific requirement for sodium ions, even in the absence of sodium ions Na+-NQR is unable to translocate protons Porphyromonas gingivalis
7.2.1.1 Na+ specific requirement for sodium ions, even in the absence of sodium ions Na+-NQR is unable to translocate protons Vibrio cholerae serotype O1
7.2.1.1 Na+ specific requirement for sodium ions, even in the absence of sodium ions Na+-NQR is unable to translocate protons Vibrio alginolyticus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
7.2.1.1 21500
-
1 * 48400 + 1 * 45400 + 1 * 27500 + 1 * 22700 + 1 * 21500 + 1 * 45200, calculated from amino acid sequence Vibrio harveyi
7.2.1.1 22700
-
1 * 48400 + 1 * 45400 + 1 * 27500 + 1 * 22700 + 1 * 21500 + 1 * 45200, calculated from amino acid sequence Vibrio harveyi
7.2.1.1 27500
-
1 * 48400 + 1 * 45400 + 1 * 27500 + 1 * 22700 + 1 * 21500 + 1 * 45200, calculated from amino acid sequence Vibrio harveyi
7.2.1.1 45200
-
1 * 48400 + 1 * 45400 + 1 * 27500 + 1 * 22700 + 1 * 21500 + 1 * 45200, calculated from amino acid sequence Vibrio harveyi
7.2.1.1 45400
-
1 * 48400 + 1 * 45400 + 1 * 27500 + 1 * 22700 + 1 * 21500 + 1 * 45200, calculated from amino acid sequence Vibrio harveyi
7.2.1.1 48400
-
1 * 48400 + 1 * 45400 + 1 * 27500 + 1 * 22700 + 1 * 21500 + 1 * 45200, calculated from amino acid sequence Vibrio harveyi

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
7.2.1.1 deamino-NADH + H+ + ubiquinone + 2 Na+/in Haemophilus influenzae
-
deamino-NAD+ + ubiquinol + 2 Na+/out
-
?
7.2.1.1 deamino-NADH + H+ + ubiquinone + 2 Na+/in Vibrio harveyi
-
deamino-NAD+ + ubiquinol + 2 Na+/out
-
?
7.2.1.1 deamino-NADH + H+ + ubiquinone + 2 Na+/in Pseudomonas aeruginosa
-
deamino-NAD+ + ubiquinol + 2 Na+/out
-
?
7.2.1.1 deamino-NADH + H+ + ubiquinone + 2 Na+/in Neisseria gonorrhoeae
-
deamino-NAD+ + ubiquinol + 2 Na+/out
-
?
7.2.1.1 deamino-NADH + H+ + ubiquinone + 2 Na+/in Neisseria meningitidis
-
deamino-NAD+ + ubiquinol + 2 Na+/out
-
?
7.2.1.1 deamino-NADH + H+ + ubiquinone + 2 Na+/in Klebsiella pneumoniae
-
deamino-NAD+ + ubiquinol + 2 Na+/out
-
?
7.2.1.1 deamino-NADH + H+ + ubiquinone + 2 Na+/in Azotobacter vinelandii
-
deamino-NAD+ + ubiquinol + 2 Na+/out
-
?
7.2.1.1 deamino-NADH + H+ + ubiquinone + 2 Na+/in Yersinia pestis
-
deamino-NAD+ + ubiquinol + 2 Na+/out
-
?
7.2.1.1 deamino-NADH + H+ + ubiquinone + 2 Na+/in Porphyromonas gingivalis
-
deamino-NAD+ + ubiquinol + 2 Na+/out
-
?
7.2.1.1 deamino-NADH + H+ + ubiquinone + 2 Na+/in Vibrio cholerae serotype O1
-
deamino-NAD+ + ubiquinol + 2 Na+/out
-
?
7.2.1.1 deamino-NADH + H+ + ubiquinone + 2 Na+/in Vibrio alginolyticus
-
deamino-NAD+ + ubiquinol + 2 Na+/out
-
?
7.2.1.1 additional information Haemophilus influenzae in addition to the quinone reductase reaction, the isolated enzyme can also catalyze the so-called NADH-dehydrogenase reaction during interaction with soluble quinones. This activity includes a single-electron reduction of soluble quinones (menadione, Q0, Q1, etc.) or some other electron acceptors (hexaammineruthenium (III), ferricyanide, etc.) ?
-
?
7.2.1.1 additional information Vibrio harveyi in addition to the quinone reductase reaction, the isolated enzyme can also catalyze the so-called NADH-dehydrogenase reaction during interaction with soluble quinones. This activity includes a single-electron reduction of soluble quinones (menadione, Q0, Q1, etc.) or some other electron acceptors (hexaammineruthenium (III), ferricyanide, etc.) ?
-
?
7.2.1.1 additional information Pseudomonas aeruginosa in addition to the quinone reductase reaction, the isolated enzyme can also catalyze the so-called NADH-dehydrogenase reaction during interaction with soluble quinones. This activity includes a single-electron reduction of soluble quinones (menadione, Q0, Q1, etc.) or some other electron acceptors (hexaammineruthenium (III), ferricyanide, etc.) ?
-
?
7.2.1.1 additional information Neisseria gonorrhoeae in addition to the quinone reductase reaction, the isolated enzyme can also catalyze the so-called NADH-dehydrogenase reaction during interaction with soluble quinones. This activity includes a single-electron reduction of soluble quinones (menadione, Q0, Q1, etc.) or some other electron acceptors (hexaammineruthenium (III), ferricyanide, etc.) ?
-
?
7.2.1.1 additional information Neisseria meningitidis in addition to the quinone reductase reaction, the isolated enzyme can also catalyze the so-called NADH-dehydrogenase reaction during interaction with soluble quinones. This activity includes a single-electron reduction of soluble quinones (menadione, Q0, Q1, etc.) or some other electron acceptors (hexaammineruthenium (III), ferricyanide, etc.) ?
-
?
7.2.1.1 additional information Klebsiella pneumoniae in addition to the quinone reductase reaction, the isolated enzyme can also catalyze the so-called NADH-dehydrogenase reaction during interaction with soluble quinones. This activity includes a single-electron reduction of soluble quinones (menadione, Q0, Q1, etc.) or some other electron acceptors (hexaammineruthenium (III), ferricyanide, etc.) ?
-
?
7.2.1.1 additional information Azotobacter vinelandii in addition to the quinone reductase reaction, the isolated enzyme can also catalyze the so-called NADH-dehydrogenase reaction during interaction with soluble quinones. This activity includes a single-electron reduction of soluble quinones (menadione, Q0, Q1, etc.) or some other electron acceptors (hexaammineruthenium (III), ferricyanide, etc.) ?
-
?
7.2.1.1 additional information Yersinia pestis in addition to the quinone reductase reaction, the isolated enzyme can also catalyze the so-called NADH-dehydrogenase reaction during interaction with soluble quinones. This activity includes a single-electron reduction of soluble quinones (menadione, Q0, Q1, etc.) or some other electron acceptors (hexaammineruthenium (III), ferricyanide, etc.) ?
-
?
7.2.1.1 additional information Porphyromonas gingivalis in addition to the quinone reductase reaction, the isolated enzyme can also catalyze the so-called NADH-dehydrogenase reaction during interaction with soluble quinones. This activity includes a single-electron reduction of soluble quinones (menadione, Q0, Q1, etc.) or some other electron acceptors (hexaammineruthenium (III), ferricyanide, etc.) ?
-
?
7.2.1.1 additional information Vibrio cholerae serotype O1 in addition to the quinone reductase reaction, the isolated enzyme can also catalyze the so-called NADH-dehydrogenase reaction during interaction with soluble quinones. This activity includes a single-electron reduction of soluble quinones (menadione, Q0, Q1, etc.) or some other electron acceptors (hexaammineruthenium (III), ferricyanide, etc.) ?
-
?
7.2.1.1 additional information Vibrio alginolyticus in addition to the quinone reductase reaction, the isolated enzyme can also catalyze the so-called NADH-dehydrogenase reaction during interaction with soluble quinones. This activity includes a single-electron reduction of soluble quinones (menadione, Q0, Q1, etc.) or some other electron acceptors (hexaammineruthenium (III), ferricyanide, etc.) ?
-
?
7.2.1.1 additional information Haemophilus influenzae Na+-NQR does not oxidize NADPH ?
-
?
7.2.1.1 additional information Vibrio harveyi Na+-NQR does not oxidize NADPH ?
-
?
7.2.1.1 additional information Pseudomonas aeruginosa Na+-NQR does not oxidize NADPH ?
-
?
7.2.1.1 additional information Neisseria gonorrhoeae Na+-NQR does not oxidize NADPH ?
-
?
7.2.1.1 additional information Neisseria meningitidis Na+-NQR does not oxidize NADPH ?
-
?
7.2.1.1 additional information Klebsiella pneumoniae Na+-NQR does not oxidize NADPH ?
-
?
7.2.1.1 additional information Azotobacter vinelandii Na+-NQR does not oxidize NADPH ?
-
?
7.2.1.1 additional information Yersinia pestis Na+-NQR does not oxidize NADPH ?
-
?
7.2.1.1 additional information Porphyromonas gingivalis Na+-NQR does not oxidize NADPH ?
-
?
7.2.1.1 additional information Vibrio cholerae serotype O1 Na+-NQR does not oxidize NADPH ?
-
?
7.2.1.1 additional information Vibrio alginolyticus Na+-NQR does not oxidize NADPH ?
-
?
7.2.1.1 NADH + H+ + ubiquinone + 2 Na+/in Haemophilus influenzae
-
NAD+ + ubiquinol + 2 Na+/out
-
?
7.2.1.1 NADH + H+ + ubiquinone + 2 Na+/in Vibrio harveyi
-
NAD+ + ubiquinol + 2 Na+/out
-
?
7.2.1.1 NADH + H+ + ubiquinone + 2 Na+/in Pseudomonas aeruginosa
-
NAD+ + ubiquinol + 2 Na+/out
-
?
7.2.1.1 NADH + H+ + ubiquinone + 2 Na+/in Neisseria gonorrhoeae
-
NAD+ + ubiquinol + 2 Na+/out
-
?
7.2.1.1 NADH + H+ + ubiquinone + 2 Na+/in Neisseria meningitidis
-
NAD+ + ubiquinol + 2 Na+/out
-
?
7.2.1.1 NADH + H+ + ubiquinone + 2 Na+/in Klebsiella pneumoniae
-
NAD+ + ubiquinol + 2 Na+/out
-
?
7.2.1.1 NADH + H+ + ubiquinone + 2 Na+/in Azotobacter vinelandii
-
NAD+ + ubiquinol + 2 Na+/out
-
?
7.2.1.1 NADH + H+ + ubiquinone + 2 Na+/in Yersinia pestis
-
NAD+ + ubiquinol + 2 Na+/out
-
?
7.2.1.1 NADH + H+ + ubiquinone + 2 Na+/in Porphyromonas gingivalis
-
NAD+ + ubiquinol + 2 Na+/out
-
?
7.2.1.1 NADH + H+ + ubiquinone + 2 Na+/in Vibrio cholerae serotype O1
-
NAD+ + ubiquinol + 2 Na+/out
-
?
7.2.1.1 NADH + H+ + ubiquinone + 2 Na+/in Vibrio alginolyticus
-
NAD+ + ubiquinol + 2 Na+/out
-
?
7.2.1.1 thio-NADH + H+ + ubiquinone + 2 Na+/in Haemophilus influenzae
-
thio-NAD+ + ubiquinol + 2 Na+/out
-
?
7.2.1.1 thio-NADH + H+ + ubiquinone + 2 Na+/in Vibrio harveyi
-
thio-NAD+ + ubiquinol + 2 Na+/out
-
?
7.2.1.1 thio-NADH + H+ + ubiquinone + 2 Na+/in Pseudomonas aeruginosa
-
thio-NAD+ + ubiquinol + 2 Na+/out
-
?
7.2.1.1 thio-NADH + H+ + ubiquinone + 2 Na+/in Neisseria gonorrhoeae
-
thio-NAD+ + ubiquinol + 2 Na+/out
-
?
7.2.1.1 thio-NADH + H+ + ubiquinone + 2 Na+/in Neisseria meningitidis
-
thio-NAD+ + ubiquinol + 2 Na+/out
-
?
7.2.1.1 thio-NADH + H+ + ubiquinone + 2 Na+/in Klebsiella pneumoniae
-
thio-NAD+ + ubiquinol + 2 Na+/out
-
?
7.2.1.1 thio-NADH + H+ + ubiquinone + 2 Na+/in Azotobacter vinelandii
-
thio-NAD+ + ubiquinol + 2 Na+/out
-
?
7.2.1.1 thio-NADH + H+ + ubiquinone + 2 Na+/in Yersinia pestis
-
thio-NAD+ + ubiquinol + 2 Na+/out
-
?
7.2.1.1 thio-NADH + H+ + ubiquinone + 2 Na+/in Porphyromonas gingivalis
-
thio-NAD+ + ubiquinol + 2 Na+/out
-
?
7.2.1.1 thio-NADH + H+ + ubiquinone + 2 Na+/in Vibrio cholerae serotype O1
-
thio-NAD+ + ubiquinol + 2 Na+/out
-
?
7.2.1.1 thio-NADH + H+ + ubiquinone + 2 Na+/in Vibrio alginolyticus
-
thio-NAD+ + ubiquinol + 2 Na+/out
-
?

Organism

EC Number Organism UniProt Comment Textmining
7.2.1.1 Azotobacter vinelandii
-
-
-
7.2.1.1 Haemophilus influenzae
-
-
-
7.2.1.1 Klebsiella pneumoniae
-
-
-
7.2.1.1 Neisseria gonorrhoeae
-
-
-
7.2.1.1 Neisseria meningitidis
-
-
-
7.2.1.1 Porphyromonas gingivalis
-
-
-
7.2.1.1 Pseudomonas aeruginosa
-
-
-
7.2.1.1 Vibrio alginolyticus
-
-
-
7.2.1.1 Vibrio cholerae serotype O1
-
-
-
7.2.1.1 Vibrio harveyi
-
-
-
7.2.1.1 Yersinia pestis
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
7.2.1.1 deamino-NADH + H+ + ubiquinone + 2 Na+/in
-
Haemophilus influenzae deamino-NAD+ + ubiquinol + 2 Na+/out
-
?
7.2.1.1 deamino-NADH + H+ + ubiquinone + 2 Na+/in
-
Vibrio harveyi deamino-NAD+ + ubiquinol + 2 Na+/out
-
?
7.2.1.1 deamino-NADH + H+ + ubiquinone + 2 Na+/in
-
Pseudomonas aeruginosa deamino-NAD+ + ubiquinol + 2 Na+/out
-
?
7.2.1.1 deamino-NADH + H+ + ubiquinone + 2 Na+/in
-
Neisseria gonorrhoeae deamino-NAD+ + ubiquinol + 2 Na+/out
-
?
7.2.1.1 deamino-NADH + H+ + ubiquinone + 2 Na+/in
-
Neisseria meningitidis deamino-NAD+ + ubiquinol + 2 Na+/out
-
?
7.2.1.1 deamino-NADH + H+ + ubiquinone + 2 Na+/in
-
Klebsiella pneumoniae deamino-NAD+ + ubiquinol + 2 Na+/out
-
?
7.2.1.1 deamino-NADH + H+ + ubiquinone + 2 Na+/in
-
Azotobacter vinelandii deamino-NAD+ + ubiquinol + 2 Na+/out
-
?
7.2.1.1 deamino-NADH + H+ + ubiquinone + 2 Na+/in
-
Yersinia pestis deamino-NAD+ + ubiquinol + 2 Na+/out
-
?
7.2.1.1 deamino-NADH + H+ + ubiquinone + 2 Na+/in
-
Porphyromonas gingivalis deamino-NAD+ + ubiquinol + 2 Na+/out
-
?
7.2.1.1 deamino-NADH + H+ + ubiquinone + 2 Na+/in
-
Vibrio cholerae serotype O1 deamino-NAD+ + ubiquinol + 2 Na+/out
-
?
7.2.1.1 deamino-NADH + H+ + ubiquinone + 2 Na+/in
-
Vibrio alginolyticus deamino-NAD+ + ubiquinol + 2 Na+/out
-
?
7.2.1.1 additional information in addition to the quinone reductase reaction, the isolated enzyme can also catalyze the so-called NADH-dehydrogenase reaction during interaction with soluble quinones. This activity includes a single-electron reduction of soluble quinones (menadione, Q0, Q1, etc.) or some other electron acceptors (hexaammineruthenium (III), ferricyanide, etc.) Haemophilus influenzae ?
-
?
7.2.1.1 additional information in addition to the quinone reductase reaction, the isolated enzyme can also catalyze the so-called NADH-dehydrogenase reaction during interaction with soluble quinones. This activity includes a single-electron reduction of soluble quinones (menadione, Q0, Q1, etc.) or some other electron acceptors (hexaammineruthenium (III), ferricyanide, etc.) Vibrio harveyi ?
-
?
7.2.1.1 additional information in addition to the quinone reductase reaction, the isolated enzyme can also catalyze the so-called NADH-dehydrogenase reaction during interaction with soluble quinones. This activity includes a single-electron reduction of soluble quinones (menadione, Q0, Q1, etc.) or some other electron acceptors (hexaammineruthenium (III), ferricyanide, etc.) Pseudomonas aeruginosa ?
-
?
7.2.1.1 additional information in addition to the quinone reductase reaction, the isolated enzyme can also catalyze the so-called NADH-dehydrogenase reaction during interaction with soluble quinones. This activity includes a single-electron reduction of soluble quinones (menadione, Q0, Q1, etc.) or some other electron acceptors (hexaammineruthenium (III), ferricyanide, etc.) Neisseria gonorrhoeae ?
-
?
7.2.1.1 additional information in addition to the quinone reductase reaction, the isolated enzyme can also catalyze the so-called NADH-dehydrogenase reaction during interaction with soluble quinones. This activity includes a single-electron reduction of soluble quinones (menadione, Q0, Q1, etc.) or some other electron acceptors (hexaammineruthenium (III), ferricyanide, etc.) Neisseria meningitidis ?
-
?
7.2.1.1 additional information in addition to the quinone reductase reaction, the isolated enzyme can also catalyze the so-called NADH-dehydrogenase reaction during interaction with soluble quinones. This activity includes a single-electron reduction of soluble quinones (menadione, Q0, Q1, etc.) or some other electron acceptors (hexaammineruthenium (III), ferricyanide, etc.) Klebsiella pneumoniae ?
-
?
7.2.1.1 additional information in addition to the quinone reductase reaction, the isolated enzyme can also catalyze the so-called NADH-dehydrogenase reaction during interaction with soluble quinones. This activity includes a single-electron reduction of soluble quinones (menadione, Q0, Q1, etc.) or some other electron acceptors (hexaammineruthenium (III), ferricyanide, etc.) Azotobacter vinelandii ?
-
?
7.2.1.1 additional information in addition to the quinone reductase reaction, the isolated enzyme can also catalyze the so-called NADH-dehydrogenase reaction during interaction with soluble quinones. This activity includes a single-electron reduction of soluble quinones (menadione, Q0, Q1, etc.) or some other electron acceptors (hexaammineruthenium (III), ferricyanide, etc.) Yersinia pestis ?
-
?
7.2.1.1 additional information in addition to the quinone reductase reaction, the isolated enzyme can also catalyze the so-called NADH-dehydrogenase reaction during interaction with soluble quinones. This activity includes a single-electron reduction of soluble quinones (menadione, Q0, Q1, etc.) or some other electron acceptors (hexaammineruthenium (III), ferricyanide, etc.) Porphyromonas gingivalis ?
-
?
7.2.1.1 additional information in addition to the quinone reductase reaction, the isolated enzyme can also catalyze the so-called NADH-dehydrogenase reaction during interaction with soluble quinones. This activity includes a single-electron reduction of soluble quinones (menadione, Q0, Q1, etc.) or some other electron acceptors (hexaammineruthenium (III), ferricyanide, etc.) Vibrio cholerae serotype O1 ?
-
?
7.2.1.1 additional information in addition to the quinone reductase reaction, the isolated enzyme can also catalyze the so-called NADH-dehydrogenase reaction during interaction with soluble quinones. This activity includes a single-electron reduction of soluble quinones (menadione, Q0, Q1, etc.) or some other electron acceptors (hexaammineruthenium (III), ferricyanide, etc.) Vibrio alginolyticus ?
-
?
7.2.1.1 additional information Na+-NQR does not oxidize NADPH Haemophilus influenzae ?
-
?
7.2.1.1 additional information Na+-NQR does not oxidize NADPH Vibrio harveyi ?
-
?
7.2.1.1 additional information Na+-NQR does not oxidize NADPH Pseudomonas aeruginosa ?
-
?
7.2.1.1 additional information Na+-NQR does not oxidize NADPH Neisseria gonorrhoeae ?
-
?
7.2.1.1 additional information Na+-NQR does not oxidize NADPH Neisseria meningitidis ?
-
?
7.2.1.1 additional information Na+-NQR does not oxidize NADPH Klebsiella pneumoniae ?
-
?
7.2.1.1 additional information Na+-NQR does not oxidize NADPH Azotobacter vinelandii ?
-
?
7.2.1.1 additional information Na+-NQR does not oxidize NADPH Yersinia pestis ?
-
?
7.2.1.1 additional information Na+-NQR does not oxidize NADPH Porphyromonas gingivalis ?
-
?
7.2.1.1 additional information Na+-NQR does not oxidize NADPH Vibrio cholerae serotype O1 ?
-
?
7.2.1.1 additional information Na+-NQR does not oxidize NADPH Vibrio alginolyticus ?
-
?
7.2.1.1 NADH + H+ + ubiquinone + 2 Na+/in
-
Haemophilus influenzae NAD+ + ubiquinol + 2 Na+/out
-
?
7.2.1.1 NADH + H+ + ubiquinone + 2 Na+/in
-
Vibrio harveyi NAD+ + ubiquinol + 2 Na+/out
-
?
7.2.1.1 NADH + H+ + ubiquinone + 2 Na+/in
-
Pseudomonas aeruginosa NAD+ + ubiquinol + 2 Na+/out
-
?
7.2.1.1 NADH + H+ + ubiquinone + 2 Na+/in
-
Neisseria gonorrhoeae NAD+ + ubiquinol + 2 Na+/out
-
?
7.2.1.1 NADH + H+ + ubiquinone + 2 Na+/in
-
Neisseria meningitidis NAD+ + ubiquinol + 2 Na+/out
-
?
7.2.1.1 NADH + H+ + ubiquinone + 2 Na+/in
-
Klebsiella pneumoniae NAD+ + ubiquinol + 2 Na+/out
-
?
7.2.1.1 NADH + H+ + ubiquinone + 2 Na+/in
-
Azotobacter vinelandii NAD+ + ubiquinol + 2 Na+/out
-
?
7.2.1.1 NADH + H+ + ubiquinone + 2 Na+/in
-
Yersinia pestis NAD+ + ubiquinol + 2 Na+/out
-
?
7.2.1.1 NADH + H+ + ubiquinone + 2 Na+/in
-
Porphyromonas gingivalis NAD+ + ubiquinol + 2 Na+/out
-
?
7.2.1.1 NADH + H+ + ubiquinone + 2 Na+/in
-
Vibrio cholerae serotype O1 NAD+ + ubiquinol + 2 Na+/out
-
?
7.2.1.1 NADH + H+ + ubiquinone + 2 Na+/in
-
Vibrio alginolyticus NAD+ + ubiquinol + 2 Na+/out
-
?
7.2.1.1 thio-NADH + H+ + ubiquinone + 2 Na+/in
-
Haemophilus influenzae thio-NAD+ + ubiquinol + 2 Na+/out
-
?
7.2.1.1 thio-NADH + H+ + ubiquinone + 2 Na+/in
-
Vibrio harveyi thio-NAD+ + ubiquinol + 2 Na+/out
-
?
7.2.1.1 thio-NADH + H+ + ubiquinone + 2 Na+/in
-
Pseudomonas aeruginosa thio-NAD+ + ubiquinol + 2 Na+/out
-
?
7.2.1.1 thio-NADH + H+ + ubiquinone + 2 Na+/in
-
Neisseria gonorrhoeae thio-NAD+ + ubiquinol + 2 Na+/out
-
?
7.2.1.1 thio-NADH + H+ + ubiquinone + 2 Na+/in
-
Neisseria meningitidis thio-NAD+ + ubiquinol + 2 Na+/out
-
?
7.2.1.1 thio-NADH + H+ + ubiquinone + 2 Na+/in
-
Klebsiella pneumoniae thio-NAD+ + ubiquinol + 2 Na+/out
-
?
7.2.1.1 thio-NADH + H+ + ubiquinone + 2 Na+/in
-
Azotobacter vinelandii thio-NAD+ + ubiquinol + 2 Na+/out
-
?
7.2.1.1 thio-NADH + H+ + ubiquinone + 2 Na+/in
-
Yersinia pestis thio-NAD+ + ubiquinol + 2 Na+/out
-
?
7.2.1.1 thio-NADH + H+ + ubiquinone + 2 Na+/in
-
Porphyromonas gingivalis thio-NAD+ + ubiquinol + 2 Na+/out
-
?
7.2.1.1 thio-NADH + H+ + ubiquinone + 2 Na+/in
-
Vibrio cholerae serotype O1 thio-NAD+ + ubiquinol + 2 Na+/out
-
?
7.2.1.1 thio-NADH + H+ + ubiquinone + 2 Na+/in
-
Vibrio alginolyticus thio-NAD+ + ubiquinol + 2 Na+/out
-
?

Subunits

EC Number Subunits Comment Organism
7.2.1.1 heterohexamer 1 * 48400 + 1 * 45400 + 1 * 27500 + 1 * 22700 + 1 * 21500 + 1 * 45200, calculated from amino acid sequence Vibrio harveyi

Synonyms

EC Number Synonyms Comment Organism
7.2.1.1 Na+-NQR
-
Haemophilus influenzae
7.2.1.1 Na+-NQR
-
Vibrio harveyi
7.2.1.1 Na+-NQR
-
Pseudomonas aeruginosa
7.2.1.1 Na+-NQR
-
Neisseria gonorrhoeae
7.2.1.1 Na+-NQR
-
Neisseria meningitidis
7.2.1.1 Na+-NQR
-
Klebsiella pneumoniae
7.2.1.1 Na+-NQR
-
Azotobacter vinelandii
7.2.1.1 Na+-NQR
-
Yersinia pestis
7.2.1.1 Na+-NQR
-
Porphyromonas gingivalis
7.2.1.1 Na+-NQR
-
Vibrio cholerae serotype O1
7.2.1.1 Na+-NQR
-
Vibrio alginolyticus
7.2.1.1 Na+-translocating NADH:ubiquinone oxidoreductase
-
Haemophilus influenzae
7.2.1.1 Na+-translocating NADH:ubiquinone oxidoreductase
-
Vibrio harveyi
7.2.1.1 Na+-translocating NADH:ubiquinone oxidoreductase
-
Pseudomonas aeruginosa
7.2.1.1 Na+-translocating NADH:ubiquinone oxidoreductase
-
Neisseria gonorrhoeae
7.2.1.1 Na+-translocating NADH:ubiquinone oxidoreductase
-
Neisseria meningitidis
7.2.1.1 Na+-translocating NADH:ubiquinone oxidoreductase
-
Klebsiella pneumoniae
7.2.1.1 Na+-translocating NADH:ubiquinone oxidoreductase
-
Azotobacter vinelandii
7.2.1.1 Na+-translocating NADH:ubiquinone oxidoreductase
-
Yersinia pestis
7.2.1.1 Na+-translocating NADH:ubiquinone oxidoreductase
-
Porphyromonas gingivalis
7.2.1.1 Na+-translocating NADH:ubiquinone oxidoreductase
-
Vibrio cholerae serotype O1
7.2.1.1 Na+-translocating NADH:ubiquinone oxidoreductase
-
Vibrio alginolyticus
7.2.1.1 sodium-translocating NADH:quinone oxidoreductase
-
Haemophilus influenzae
7.2.1.1 sodium-translocating NADH:quinone oxidoreductase
-
Vibrio harveyi
7.2.1.1 sodium-translocating NADH:quinone oxidoreductase
-
Pseudomonas aeruginosa
7.2.1.1 sodium-translocating NADH:quinone oxidoreductase
-
Neisseria gonorrhoeae
7.2.1.1 sodium-translocating NADH:quinone oxidoreductase
-
Neisseria meningitidis
7.2.1.1 sodium-translocating NADH:quinone oxidoreductase
-
Klebsiella pneumoniae
7.2.1.1 sodium-translocating NADH:quinone oxidoreductase
-
Azotobacter vinelandii
7.2.1.1 sodium-translocating NADH:quinone oxidoreductase
-
Yersinia pestis
7.2.1.1 sodium-translocating NADH:quinone oxidoreductase
-
Porphyromonas gingivalis
7.2.1.1 sodium-translocating NADH:quinone oxidoreductase
-
Vibrio cholerae serotype O1
7.2.1.1 sodium-translocating NADH:quinone oxidoreductase
-
Vibrio alginolyticus

Cofactor

EC Number Cofactor Comment Organism Structure
7.2.1.1 FAD noncovalently bound to the NqrF subunit of Na+-NQR Haemophilus influenzae
7.2.1.1 FAD noncovalently bound to the NqrF subunit of Na+-NQR Vibrio harveyi
7.2.1.1 FAD noncovalently bound to the NqrF subunit of Na+-NQR Pseudomonas aeruginosa
7.2.1.1 FAD noncovalently bound to the NqrF subunit of Na+-NQR Neisseria gonorrhoeae
7.2.1.1 FAD noncovalently bound to the NqrF subunit of Na+-NQR Neisseria meningitidis
7.2.1.1 FAD noncovalently bound to the NqrF subunit of Na+-NQR Klebsiella pneumoniae
7.2.1.1 FAD noncovalently bound to the NqrF subunit of Na+-NQR Azotobacter vinelandii
7.2.1.1 FAD noncovalently bound to the NqrF subunit of Na+-NQR Yersinia pestis
7.2.1.1 FAD noncovalently bound to the NqrF subunit of Na+-NQR Porphyromonas gingivalis
7.2.1.1 FAD noncovalently bound to the NqrF subunit of Na+-NQR Vibrio cholerae serotype O1
7.2.1.1 FAD noncovalently bound to the NqrF subunit of Na+-NQR Vibrio alginolyticus
7.2.1.1 FMN covalently bound to the NqrB and NqrC subunits of Na+-NQR Haemophilus influenzae
7.2.1.1 FMN covalently bound to the NqrB and NqrC subunits of Na+-NQR Vibrio harveyi
7.2.1.1 FMN covalently bound to the NqrB and NqrC subunits of Na+-NQR Pseudomonas aeruginosa
7.2.1.1 FMN covalently bound to the NqrB and NqrC subunits of Na+-NQR Neisseria gonorrhoeae
7.2.1.1 FMN covalently bound to the NqrB and NqrC subunits of Na+-NQR Neisseria meningitidis
7.2.1.1 FMN covalently bound to the NqrB and NqrC subunits of Na+-NQR Klebsiella pneumoniae
7.2.1.1 FMN covalently bound to the NqrB and NqrC subunits of Na+-NQR Azotobacter vinelandii
7.2.1.1 FMN covalently bound to the NqrB and NqrC subunits of Na+-NQR Yersinia pestis
7.2.1.1 FMN covalently bound to the NqrB and NqrC subunits of Na+-NQR Porphyromonas gingivalis
7.2.1.1 FMN covalently bound to the NqrB and NqrC subunits of Na+-NQR Vibrio cholerae serotype O1
7.2.1.1 FMN covalently bound to the NqrB and NqrC subunits of Na+-NQR Vibrio alginolyticus
7.2.1.1 NADH Na+-NQR is specific to NADH Haemophilus influenzae
7.2.1.1 NADH Na+-NQR is specific to NADH Vibrio harveyi
7.2.1.1 NADH Na+-NQR is specific to NADH Pseudomonas aeruginosa
7.2.1.1 NADH Na+-NQR is specific to NADH Neisseria gonorrhoeae
7.2.1.1 NADH Na+-NQR is specific to NADH Neisseria meningitidis
7.2.1.1 NADH Na+-NQR is specific to NADH Klebsiella pneumoniae
7.2.1.1 NADH Na+-NQR is specific to NADH Azotobacter vinelandii
7.2.1.1 NADH Na+-NQR is specific to NADH Yersinia pestis
7.2.1.1 NADH Na+-NQR is specific to NADH Porphyromonas gingivalis
7.2.1.1 NADH Na+-NQR is specific to NADH Vibrio cholerae serotype O1
7.2.1.1 NADH Na+-NQR is specific to NADH Vibrio alginolyticus
7.2.1.1 riboflavin the enzyme contains one noncovalently bound riboflavin Haemophilus influenzae
7.2.1.1 riboflavin the enzyme contains one noncovalently bound riboflavin Vibrio harveyi
7.2.1.1 riboflavin the enzyme contains one noncovalently bound riboflavin Pseudomonas aeruginosa
7.2.1.1 riboflavin the enzyme contains one noncovalently bound riboflavin Neisseria gonorrhoeae
7.2.1.1 riboflavin the enzyme contains one noncovalently bound riboflavin Neisseria meningitidis
7.2.1.1 riboflavin the enzyme contains one noncovalently bound riboflavin Klebsiella pneumoniae
7.2.1.1 riboflavin the enzyme contains one noncovalently bound riboflavin Azotobacter vinelandii
7.2.1.1 riboflavin the enzyme contains one noncovalently bound riboflavin Yersinia pestis
7.2.1.1 riboflavin the enzyme contains one noncovalently bound riboflavin Porphyromonas gingivalis
7.2.1.1 riboflavin the enzyme contains one noncovalently bound riboflavin Vibrio cholerae serotype O1
7.2.1.1 riboflavin the enzyme contains one noncovalently bound riboflavin Vibrio alginolyticus
7.2.1.1 ubiquinone-8 the enzyme contains one ubiquinone-8 Haemophilus influenzae
7.2.1.1 ubiquinone-8 the enzyme contains one ubiquinone-8 Vibrio harveyi
7.2.1.1 ubiquinone-8 the enzyme contains one ubiquinone-8 Pseudomonas aeruginosa
7.2.1.1 ubiquinone-8 the enzyme contains one ubiquinone-8 Neisseria gonorrhoeae
7.2.1.1 ubiquinone-8 the enzyme contains one ubiquinone-8 Neisseria meningitidis
7.2.1.1 ubiquinone-8 the enzyme contains one ubiquinone-8 Klebsiella pneumoniae
7.2.1.1 ubiquinone-8 the enzyme contains one ubiquinone-8 Azotobacter vinelandii
7.2.1.1 ubiquinone-8 the enzyme contains one ubiquinone-8 Yersinia pestis
7.2.1.1 ubiquinone-8 the enzyme contains one ubiquinone-8 Porphyromonas gingivalis
7.2.1.1 ubiquinone-8 the enzyme contains one ubiquinone-8 Vibrio cholerae serotype O1
7.2.1.1 ubiquinone-8 the enzyme contains one ubiquinone-8 Vibrio alginolyticus
7.2.1.1 [2Fe-2S]-center part of the NqrF subunit of Na+-NQR Haemophilus influenzae
7.2.1.1 [2Fe-2S]-center part of the NqrF subunit of Na+-NQR Vibrio harveyi
7.2.1.1 [2Fe-2S]-center part of the NqrF subunit of Na+-NQR Pseudomonas aeruginosa
7.2.1.1 [2Fe-2S]-center part of the NqrF subunit of Na+-NQR Neisseria gonorrhoeae
7.2.1.1 [2Fe-2S]-center part of the NqrF subunit of Na+-NQR Neisseria meningitidis
7.2.1.1 [2Fe-2S]-center part of the NqrF subunit of Na+-NQR Klebsiella pneumoniae
7.2.1.1 [2Fe-2S]-center part of the NqrF subunit of Na+-NQR Azotobacter vinelandii
7.2.1.1 [2Fe-2S]-center part of the NqrF subunit of Na+-NQR Yersinia pestis
7.2.1.1 [2Fe-2S]-center part of the NqrF subunit of Na+-NQR Porphyromonas gingivalis
7.2.1.1 [2Fe-2S]-center part of the NqrF subunit of Na+-NQR Vibrio cholerae serotype O1
7.2.1.1 [2Fe-2S]-center part of the NqrF subunit of Na+-NQR Vibrio alginolyticus