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Literature summary extracted from

  • Queiroz-Madeira, E.P.; Lara, L.S.; Wengert, M.; Landgraf, S.S.; Libano-Soares, J.D.; Zapata-Sudo, G.; Sudo, R.T.; Takiya, C.M.; Gomes-Quintana, E.; Lopes, A.G.; Caruso-Neves, C.
    Na+-ATPase in spontaneous hypertensive rats: possible AT1 receptor target in the development of hypertension (2010), Biochim. Biophys. Acta, 1798, 360-366.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
7.2.2.3 angiotensin II angiotensin II has an activating and regulatory role for Na+-ATPase activity in healthy rats, and angiotensin II links the enzyme activity to hypertension in spontaneously hypertensive rats, where it has an inhibitory effect on Na+-ATPase activity. Ang II interacts with different receptors in spontaneously hypertensive rats and WKY wild-type rats Rattus norvegicus
7.2.2.3 additional information a system leading to activation of the enzyme in spontaneously hypertensive rats is inhibited by AT2-mediated Ang II Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
7.2.2.3 angiotensin II angiotensin II has an activating and regulatory role for Na+-ATPase activity in healthy rats, and angiotensin II links the enzyme activity to hypertension in spontaneously hypertensive rats, where it has an inhibitory effect on Na+-ATPase activity. The Ang II inhibitory effect is completely reversed by a specific antagonist of AT2 receptor, PD123319. Ang II interacts with different receptors in spontaneously hypertensive rats and WKY wild-type rats Rattus norvegicus
7.2.2.3 losartan prevents the increase in Na+-ATPase activity observed in 14-weekold spontaneously hypertensive rats Rattus norvegicus
7.2.2.3 additional information ouabain-insensitive Na+-ATPase. A system leading to activation of the enzyme in spontaneously hypertensive rats is inhibited by AT2-mediated Ang II Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
7.2.2.3 additional information
-
additional information Michaelis-Menten kinetics Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
7.2.2.3 membrane
-
Rattus norvegicus 16020
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
7.2.2.3 Mg2+ required Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
7.2.2.3 ATP + H2O + Na+/in Rattus norvegicus
-
ADP + phosphate + Na+/out
-
?

Organism

EC Number Organism UniProt Comment Textmining
7.2.2.3 Rattus norvegicus
-
WKY rats and spontaneously hypertensive rats
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
7.2.2.3 kidney cortex Rattus norvegicus
-
7.2.2.3 renal tubule basolateral membranes of kidney proximal tubule cells Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
7.2.2.3 ATP + H2O + Na+/in
-
Rattus norvegicus ADP + phosphate + Na+/out
-
?

Synonyms

EC Number Synonyms Comment Organism
7.2.2.3 Na+-ATPase
-
Rattus norvegicus
7.2.2.3 ouabain-insensitive Na+-ATPase
-
Rattus norvegicus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
7.2.2.3 37
-
assay at Rattus norvegicus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
7.2.2.3 7
-
assay at Rattus norvegicus

General Information

EC Number General Information Comment Organism
7.2.2.3 additional information increase in sodium reabsorption on the proximal tubule in essential hypertension. Na+-ATPase activity is enhanced in14-week-old but not in 6-week-old spontaneously hypertensive rats. correlation between AT1 receptor activation in spontaneously hypertensive rats and increased ouabaininsensitive Na+-ATPase activity. Ang II interacts with different receptors in spontaneously hypertensive rats and WKY wild-type rats. The AT1 receptor is responsible for activation in spontaneously hypertensive rats. Role of the AT2 receptor in counteracting the AT1 receptor to achieve hydroelectrolytic balance in normotensive rats Rattus norvegicus