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Literature summary extracted from

  • Fernandez, J.R.; Sweet, E.S.; Welsh, W.J.; Firestein, B.L.
    Identification of small molecule compounds with higher binding affinity to guanine deaminase (cypin) than guanine (2010), Bioorg. Med. Chem., 18, 6748-6755.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.5.4.3 2-dimethylamino-6-hydroxypurine promotes GDA activity when guanine is added Rattus norvegicus
3.5.4.3 2-dimethylamino-6-hydroxypurine promotes GDA activity when guanine is added Oryctolagus cuniculus

Application

EC Number Application Comment Organism
3.5.4.3 medicine GDA is an attractive and potential drug target for treatment of both liver diseases and cognitive disorders Rattus norvegicus
3.5.4.3 medicine GDA is an attractive and potential drug target for treatment of both liver diseases and cognitive disorders Oryctolagus cuniculus
3.5.4.3 medicine GDA is an attractive and potential drug target for treatment of both liver diseases and cognitive disorders Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.5.4.3 2,6-diaminopurine
-
 Homo sapiens
3.5.4.3 2,6-diaminopurine
-
 Oryctolagus cuniculus
3.5.4.3 2,6-diaminopurine
-
 Rattus norvegicus
3.5.4.3 5-amino-4-imidazole carboxamide
-
 Homo sapiens
3.5.4.3 5-amino-4-imidazole carboxamide
-
 Oryctolagus cuniculus
3.5.4.3 5-amino-4-imidazole carboxamide
-
 Rattus norvegicus
3.5.4.3 7-methylguanine
-
 Homo sapiens
3.5.4.3 7-methylguanine
-
 Oryctolagus cuniculus
3.5.4.3 7-methylguanine
-
 Rattus norvegicus
3.5.4.3 Caffeine
-
 Homo sapiens
3.5.4.3 Caffeine
-
 Oryctolagus cuniculus
3.5.4.3 Caffeine
-
 Rattus norvegicus
3.5.4.3 N-2-acetylguanine
-
 Homo sapiens
3.5.4.3 N-2-acetylguanine
-
 Oryctolagus cuniculus
3.5.4.3 N-2-acetylguanine
-
 Rattus norvegicus
3.5.4.3 uric acid
-
 Homo sapiens
3.5.4.3 uric acid
-
 Oryctolagus cuniculus
3.5.4.3 uric acid
-
 Rattus norvegicus
3.5.4.3 xanthine
-
 Homo sapiens
3.5.4.3 xanthine
-
 Oryctolagus cuniculus
3.5.4.3 xanthine
-
 Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.5.4.3 0.01121
-
 guanine in 25 mM Tris-HCl, 137 mM NaCl, 2.7 mM KCl, at pH 7.4 and 25°C Rattus norvegicus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.5.4.3 Zn2+ contains zinc Rattus norvegicus
3.5.4.3 Zn2+ contains zinc Oryctolagus cuniculus
3.5.4.3 Zn2+ contains zinc Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.5.4.3 Homo sapiens Q9Y2T3
-
-
3.5.4.3 Oryctolagus cuniculus
-
-
-
3.5.4.3 Rattus norvegicus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.5.4.3
-
 Oryctolagus cuniculus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.5.4.3 liver
-
 Oryctolagus cuniculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.5.4.3 guanine + H2O
-
 Rattus norvegicus xanthine + NH3
-
 ?
3.5.4.3 guanine + H2O
-
 Oryctolagus cuniculus xanthine + NH3
-
 ?
3.5.4.3 guanine + H2O
-
 Homo sapiens xanthine + NH3
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.5.4.3 cypin
-
 Rattus norvegicus
3.5.4.3 cypin
-
 Oryctolagus cuniculus
3.5.4.3 cypin
-
 Homo sapiens
3.5.4.3 GDA
-
 Rattus norvegicus
3.5.4.3 GDA
-
 Oryctolagus cuniculus
3.5.4.3 GDA
-
 Homo sapiens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
3.5.4.3 0.00188
-
 2,6-diaminopurine in 25 mM Tris-HCl, 137 mM NaCl, 2.7 mM KCl, at pH 7.4 and 25°C Oryctolagus cuniculus
3.5.4.3 0.00196
-
 xanthine in 25 mM Tris-HCl, 137 mM NaCl, 2.7 mM KCl, at pH 7.4 and 25°C Oryctolagus cuniculus
3.5.4.3 0.00344
-
 N-2-acetylguanine in 25 mM Tris-HCl, 137 mM NaCl, 2.7 mM KCl, at pH 7.4 and 25°C Oryctolagus cuniculus
3.5.4.3 0.00434
-
 uric acid in 25 mM Tris-HCl, 137 mM NaCl, 2.7 mM KCl, at pH 7.4 and 25°C Oryctolagus cuniculus
3.5.4.3 0.00444
-
 5-amino-4-imidazole carboxamide in 25 mM Tris-HCl, 137 mM NaCl, 2.7 mM KCl, at pH 7.4 and 25°C Oryctolagus cuniculus
3.5.4.3 0.00555
-
 7-methylguanine in 25 mM Tris-HCl, 137 mM NaCl, 2.7 mM KCl, at pH 7.4 and 25°C Oryctolagus cuniculus
3.5.4.3 0.0102
-
 Caffeine in 25 mM Tris-HCl, 137 mM NaCl, 2.7 mM KCl, at pH 7.4 and 25°C Oryctolagus cuniculus

General Information

EC Number General Information Comment Organism
3.5.4.3 physiological function GDA (cypin) mediates microtubule assembly Rattus norvegicus
3.5.4.3 physiological function GDA (cypin) mediates microtubule assembly Oryctolagus cuniculus
3.5.4.3 physiological function GDA (cypin) mediates microtubule assembly Homo sapiens