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Literature summary extracted from

  • Rohlin, L.; Gunsalus, R.P.
    Carbon-dependent control of electron transfer and central carbon pathway genes for methane biosynthesis in the Archaean, Methanosarcina acetivorans strain C2A (2010), BMC Microbiol., 10, 62.
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.2.7.12 formylmethanofuran + H2O + oxidized ferredoxin Methanosarcina acetivorans
-
 CO2 + methanofuran + reduced ferredoxin
-
 r

Organism

EC Number Organism UniProt Comment Textmining
1.2.7.12 Methanosarcina acetivorans
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.2.7.12 formylmethanofuran + H2O + oxidized ferredoxin
-
 Methanosarcina acetivorans CO2 + methanofuran + reduced ferredoxin
-
 r

Synonyms

EC Number Synonyms Comment Organism
1.2.7.12 molybdenum-type formylmethanofuran dehydrogenase
-
 Methanosarcina acetivorans
1.2.7.12 tungsten-type formylmethanofuran dehydrogenase
-
 Methanosarcina acetivorans

Expression

EC Number Organism Comment Expression
1.2.7.12 Methanosarcina acetivorans the molybdenum-type formylmethanofuran dehydrogenase operon reporter genes fmdE1 and fmdA1 are expressed at 14fold higher levels during methanol growth conditions relative to acetate growth. Genes fmdF2, fmdA2, and fmdB2 are expressed about 2fold higher during these conditions, but the maximal level of expression is less than 5% of that seen for the fmdE1 and fmdA1 genes. The tungsten-type formylmethanofuran dehydrogenase genes fwdB1 and fwdA1 are also expressed 15fold higher levels during methanol growth relative to acetate up