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Literature summary extracted from

  • Gao, L.; Mann, G.E.
    Vascular NAD(P)H oxidase activation in diabetes: a double-edged sword in redox signalling (2009), Cardiovasc. Res., 82, 9-20.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.6.3.1 angiotensin II potent stimulator of NAD(P)H oxidase O2- production in the vasculature Mus musculus
1.6.3.1 angiotensin II potent stimulator of NAD(P)H oxidase O2- production in the vasculature Homo sapiens
1.6.3.1 angiotensin II potent stimulator of NAD(P)H oxidase O2- production in the vasculature Rattus norvegicus
1.6.3.1 angiotensin II potent stimulator of NAD(P)H oxidase O2- production in the vasculature Bos taurus

Application

EC Number Application Comment Organism
1.6.3.1 medicine as NAD(P)H oxidase activation may have dual actions in diabetes, selective targeting of the deleterious effects of sustained NAD(P)H oxidase activation, such as eNOS uncoupling, mitochondrial dysfunction, and impaired antioxidant gene expression, may prove beneficial in the treatment of diabetes Mus musculus
1.6.3.1 medicine as NAD(P)H oxidase activation may have dual actions in diabetes, selective targeting of the deleterious effects of sustained NAD(P)H oxidase activation, such as eNOS uncoupling, mitochondrial dysfunction, and impaired antioxidant gene expression, may prove beneficial in the treatment of diabetes Homo sapiens
1.6.3.1 medicine as NAD(P)H oxidase activation may have dual actions in diabetes, selective targeting of the deleterious effects of sustained NAD(P)H oxidase activation, such as eNOS uncoupling, mitochondrial dysfunction, and impaired antioxidant gene expression, may prove beneficial in the treatment of diabetes Rattus norvegicus
1.6.3.1 medicine as NAD(P)H oxidase activation may have dual actions in diabetes, selective targeting of the deleterious effects of sustained NAD(P)H oxidase activation, such as eNOS uncoupling, mitochondrial dysfunction, and impaired antioxidant gene expression, may prove beneficial in the treatment of diabetes Bos taurus

Protein Variants

EC Number Protein Variants Comment Organism
1.6.3.1 additional information a C242T mutation in the p22phox gene is associated with insulin resistance in non-diabetic subjects Mus musculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.6.3.1 diphenylene iodonium
-
Bos taurus
1.6.3.1 diphenylene iodonium
-
Homo sapiens
1.6.3.1 diphenylene iodonium
-
Mus musculus
1.6.3.1 diphenylene iodonium
-
Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.6.3.1 membrane
-
Mus musculus 16020
-
1.6.3.1 membrane
-
Homo sapiens 16020
-
1.6.3.1 membrane
-
Rattus norvegicus 16020
-
1.6.3.1 membrane
-
Bos taurus 16020
-

Organism

EC Number Organism UniProt Comment Textmining
1.6.3.1 Bos taurus
-
-
-
1.6.3.1 Homo sapiens
-
-
-
1.6.3.1 Mus musculus
-
-
-
1.6.3.1 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.6.3.1 aortic endothelial cell
-
Bos taurus
-
1.6.3.1 aortic smooth muscle cell
-
Mus musculus
-
1.6.3.1 aortic smooth muscle cell
-
Homo sapiens
-
1.6.3.1 aortic smooth muscle cell
-
Rattus norvegicus
-
1.6.3.1 aortic smooth muscle cell
-
Bos taurus
-
1.6.3.1 bone
-
Mus musculus
-
1.6.3.1 bone
-
Homo sapiens
-
1.6.3.1 bone
-
Rattus norvegicus
-
1.6.3.1 bone
-
Bos taurus
-
1.6.3.1 brain
-
Mus musculus
-
1.6.3.1 brain
-
Homo sapiens
-
1.6.3.1 brain
-
Rattus norvegicus
-
1.6.3.1 brain
-
Bos taurus
-
1.6.3.1 breast
-
Mus musculus
-
1.6.3.1 breast
-
Homo sapiens
-
1.6.3.1 breast
-
Rattus norvegicus
-
1.6.3.1 breast
-
Bos taurus
-
1.6.3.1 colon
-
Mus musculus
-
1.6.3.1 colon
-
Homo sapiens
-
1.6.3.1 colon
-
Rattus norvegicus
-
1.6.3.1 colon
-
Bos taurus
-
1.6.3.1 coronary artery endothelial cell
-
Rattus norvegicus
-
1.6.3.1 coronary artery endothelial cell
-
Bos taurus
-
1.6.3.1 endothelial cell
-
Mus musculus
-
1.6.3.1 endothelium
-
Mus musculus
-
1.6.3.1 endothelium
-
Homo sapiens
-
1.6.3.1 endothelium
-
Rattus norvegicus
-
1.6.3.1 endothelium
-
Bos taurus
-
1.6.3.1 eye
-
Mus musculus
-
1.6.3.1 eye
-
Homo sapiens
-
1.6.3.1 eye
-
Rattus norvegicus
-
1.6.3.1 eye
-
Bos taurus
-
1.6.3.1 gastrointestinal tract
-
Mus musculus
-
1.6.3.1 gastrointestinal tract
-
Homo sapiens
-
1.6.3.1 gastrointestinal tract
-
Rattus norvegicus
-
1.6.3.1 gastrointestinal tract
-
Bos taurus
-
1.6.3.1 heart
-
Mus musculus
-
1.6.3.1 heart
-
Homo sapiens
-
1.6.3.1 heart
-
Rattus norvegicus
-
1.6.3.1 heart
-
Bos taurus
-
1.6.3.1 HUVEC cell
-
Homo sapiens
-
1.6.3.1 inner ear
-
Mus musculus
-
1.6.3.1 inner ear
-
Homo sapiens
-
1.6.3.1 inner ear
-
Rattus norvegicus
-
1.6.3.1 inner ear
-
Bos taurus
-
1.6.3.1 kidney Nox4 is the predominant isoform expressed in renal cells Mus musculus
-
1.6.3.1 kidney Nox4 is the predominant isoform expressed in renal cells Homo sapiens
-
1.6.3.1 kidney Nox4 is the predominant isoform expressed in renal cells Rattus norvegicus
-
1.6.3.1 kidney Nox4 is the predominant isoform expressed in renal cells Bos taurus
-
1.6.3.1 lung
-
Mus musculus
-
1.6.3.1 lung
-
Homo sapiens
-
1.6.3.1 lung
-
Rattus norvegicus
-
1.6.3.1 lung
-
Bos taurus
-
1.6.3.1 lymphoid tissue
-
Mus musculus
-
1.6.3.1 lymphoid tissue
-
Homo sapiens
-
1.6.3.1 lymphoid tissue
-
Rattus norvegicus
-
1.6.3.1 lymphoid tissue
-
Bos taurus
-
1.6.3.1 microvessel
-
Mus musculus
-
1.6.3.1 ovary
-
Mus musculus
-
1.6.3.1 ovary
-
Homo sapiens
-
1.6.3.1 ovary
-
Rattus norvegicus
-
1.6.3.1 ovary
-
Bos taurus
-
1.6.3.1 phagocyte
-
Mus musculus
-
1.6.3.1 phagocyte
-
Homo sapiens
-
1.6.3.1 phagocyte
-
Rattus norvegicus
-
1.6.3.1 phagocyte
-
Bos taurus
-
1.6.3.1 placenta
-
Mus musculus
-
1.6.3.1 placenta
-
Homo sapiens
-
1.6.3.1 placenta
-
Rattus norvegicus
-
1.6.3.1 placenta
-
Bos taurus
-
1.6.3.1 prostate gland
-
Mus musculus
-
1.6.3.1 prostate gland
-
Homo sapiens
-
1.6.3.1 prostate gland
-
Rattus norvegicus
-
1.6.3.1 prostate gland
-
Bos taurus
-
1.6.3.1 retina
-
Mus musculus
-
1.6.3.1 retina
-
Homo sapiens
-
1.6.3.1 retina
-
Rattus norvegicus
-
1.6.3.1 retina
-
Bos taurus
-
1.6.3.1 salivary gland
-
Mus musculus
-
1.6.3.1 salivary gland
-
Homo sapiens
-
1.6.3.1 salivary gland
-
Rattus norvegicus
-
1.6.3.1 salivary gland
-
Bos taurus
-
1.6.3.1 skeletal muscle
-
Mus musculus
-
1.6.3.1 skeletal muscle
-
Homo sapiens
-
1.6.3.1 skeletal muscle
-
Rattus norvegicus
-
1.6.3.1 skeletal muscle
-
Bos taurus
-
1.6.3.1 spleen
-
Mus musculus
-
1.6.3.1 spleen
-
Homo sapiens
-
1.6.3.1 spleen
-
Rattus norvegicus
-
1.6.3.1 spleen
-
Bos taurus
-
1.6.3.1 testis
-
Mus musculus
-
1.6.3.1 testis
-
Homo sapiens
-
1.6.3.1 testis
-
Rattus norvegicus
-
1.6.3.1 testis
-
Bos taurus
-
1.6.3.1 thyroid
-
Mus musculus
-
1.6.3.1 thyroid
-
Homo sapiens
-
1.6.3.1 thyroid
-
Rattus norvegicus
-
1.6.3.1 thyroid
-
Bos taurus
-
1.6.3.1 uterus
-
Mus musculus
-
1.6.3.1 uterus
-
Homo sapiens
-
1.6.3.1 uterus
-
Rattus norvegicus
-
1.6.3.1 uterus
-
Bos taurus
-
1.6.3.1 vasculature
-
Mus musculus
-
1.6.3.1 vasculature
-
Homo sapiens
-
1.6.3.1 vasculature
-
Rattus norvegicus
-
1.6.3.1 vasculature
-
Bos taurus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.6.3.1 NADH + H+ + O2
-
Mus musculus NAD+ + H2O2
-
?
1.6.3.1 NADH + H+ + O2
-
Homo sapiens NAD+ + H2O2
-
?
1.6.3.1 NADH + H+ + O2
-
Rattus norvegicus NAD+ + H2O2
-
?
1.6.3.1 NADH + H+ + O2
-
Bos taurus NAD+ + H2O2
-
?
1.6.3.1 NADPH + H+ + O2
-
Mus musculus NADP+ + H2O2
-
?
1.6.3.1 NADPH + H+ + O2
-
Homo sapiens NADP+ + H2O2
-
?
1.6.3.1 NADPH + H+ + O2
-
Rattus norvegicus NADP+ + H2O2
-
?
1.6.3.1 NADPH + H+ + O2
-
Bos taurus NADP+ + H2O2
-
?

Synonyms

EC Number Synonyms Comment Organism
1.6.3.1 Duox1 isoform Mus musculus
1.6.3.1 Duox1 isoform Homo sapiens
1.6.3.1 Duox1 isoform Rattus norvegicus
1.6.3.1 Duox1 isoform Bos taurus
1.6.3.1 Duox2 isoform Mus musculus
1.6.3.1 Duox2 isoform Homo sapiens
1.6.3.1 Duox2 isoform Rattus norvegicus
1.6.3.1 Duox2 isoform Bos taurus
1.6.3.1 NADPH oxidase
-
Mus musculus
1.6.3.1 NADPH oxidase
-
Homo sapiens
1.6.3.1 NADPH oxidase
-
Rattus norvegicus
1.6.3.1 NADPH oxidase
-
Bos taurus
1.6.3.1 NOX1 isoform Mus musculus
1.6.3.1 NOX1 isoform Homo sapiens
1.6.3.1 NOX1 isoform Rattus norvegicus
1.6.3.1 NOX1 isoform Bos taurus
1.6.3.1 Nox2 isoform Mus musculus
1.6.3.1 Nox2 isoform Homo sapiens
1.6.3.1 Nox2 isoform Rattus norvegicus
1.6.3.1 Nox2 isoform Bos taurus
1.6.3.1 NOX3 isoform Mus musculus
1.6.3.1 NOX3 isoform Homo sapiens
1.6.3.1 NOX3 isoform Rattus norvegicus
1.6.3.1 NOX3 isoform Bos taurus
1.6.3.1 Nox4 isoform Mus musculus
1.6.3.1 Nox4 isoform Homo sapiens
1.6.3.1 Nox4 isoform Rattus norvegicus
1.6.3.1 Nox4 isoform Bos taurus
1.6.3.1 NOX5 isoform Mus musculus
1.6.3.1 NOX5 isoform Homo sapiens
1.6.3.1 NOX5 isoform Rattus norvegicus
1.6.3.1 NOX5 isoform Bos taurus

Cofactor

EC Number Cofactor Comment Organism Structure
1.6.3.1 FAD
-
Mus musculus
1.6.3.1 FAD
-
Homo sapiens
1.6.3.1 FAD
-
Rattus norvegicus
1.6.3.1 FAD
-
Bos taurus
1.6.3.1 heme
-
Mus musculus
1.6.3.1 heme
-
Homo sapiens
1.6.3.1 heme
-
Rattus norvegicus
1.6.3.1 heme
-
Bos taurus

Expression

EC Number Organism Comment Expression
1.6.3.1 Rattus norvegicus adiponectin suppresses NADPH oxidase expression/activity down
1.6.3.1 Homo sapiens leptin suppresses NADPH oxidase expression/activity down
1.6.3.1 Bos taurus fatty acids activate NADPH oxidase expression/activity up
1.6.3.1 Rattus norvegicus tumor necrosis factor-alpha activates NADPH oxidase expression/activity. NAD(P)H oxidase is increased in the retina of diabetic rats up

General Information

EC Number General Information Comment Organism
1.6.3.1 physiological function NAD(P)H oxidase is the major source of reactive oxygen species generation in the vasculature in response to high glucose and advanced glycation end-products. NAD(P)H oxidase in phagocytic cells releases reactive oxygen species as a defense against pathogens. Activation of NAD(P)H oxidase in diabetes leads to a cascade of reactive oxygen species production and impaired antioxidant defenses. In early stages of diabetes, NAD(P)H oxidase-derived reactive oxygen species may serve as intracellular mediators to regulate redox-sensitive transcription factors (e.g. Nrf2) involved in adaptive responses to oxidative stress Mus musculus
1.6.3.1 physiological function NAD(P)H oxidase is the major source of reactive oxygen species generation in the vasculature in response to high glucose and advanced glycation end-products. NAD(P)H oxidase in phagocytic cells releases reactive oxygen species as a defense against pathogens. Activation of NAD(P)H oxidase in diabetes leads to a cascade of reactive oxygen species production and impaired antioxidant defenses. In early stages of diabetes, NAD(P)H oxidase-derived reactive oxygen species may serve as intracellular mediators to regulate redox-sensitive transcription factors (e.g. Nrf2) involved in adaptive responses to oxidative stress Homo sapiens
1.6.3.1 physiological function NAD(P)H oxidase is the major source of reactive oxygen species generation in the vasculature in response to high glucose and advanced glycation end-products. NAD(P)H oxidase in phagocytic cells releases reactive oxygen species as a defense against pathogens. Activation of NAD(P)H oxidase in diabetes leads to a cascade of reactive oxygen species production and impaired antioxidant defenses. In early stages of diabetes, NAD(P)H oxidase-derived reactive oxygen species may serve as intracellular mediators to regulate redox-sensitive transcription factors (e.g. Nrf2) involved in adaptive responses to oxidative stress Rattus norvegicus
1.6.3.1 physiological function NAD(P)H oxidase is the major source of reactive oxygen species generation in the vasculature in response to high glucose and advanced glycation end-products. NAD(P)H oxidase in phagocytic cells releases reactive oxygen species as a defense against pathogens. Activation of NAD(P)H oxidase in diabetes leads to a cascade of reactive oxygen species production and impaired antioxidant defenses. In early stages of diabetes, NAD(P)H oxidase-derived reactive oxygen species may serve as intracellular mediators to regulate redox-sensitive transcription factors (e.g. Nrf2) involved in adaptive responses to oxidative stress Bos taurus