EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
7.6.2.2 | beta-sitosterol-O-glucoside | inhibits the efflux of the P-gp substrate rhodamine 123 in a concentration-dependent manner. Good candidates for the development of novel P-gp/MDR1 reversal agents which may enhance the accumulation and efficacy of chemotherapy agents | Homo sapiens | |
7.6.2.2 | deacetylnomilin | inhibits the efflux of the P-gp substrate rhodamine 123 in a concentration-dependent manner. Good candidates for the development of novel P-gp/MDR1 reversal agents which may enhance the accumulation and efficacy of chemotherapy agents. Good candidates for the development of novel P-gp/MDR1 reversal agents which may enhance the accumulation and efficacy of chemotherapy agents | Homo sapiens | |
7.6.2.2 | hesperidin | inhibits the efflux of the P-gp substrate rhodamine 123 in a concentration-dependent manner. Good candidates for the development of novel P-gp/MDR1 reversal agents which may enhance the accumulation and efficacy of chemotherapy agents | Homo sapiens | |
7.6.2.2 | limonin | inhibits the efflux of the P-gp substrate rhodamine 123 in a concentration-dependent manner. Good candidates for the development of novel P-gp/MDR1 reversal agents which may enhance the accumulation and efficacy of chemotherapy agents | Homo sapiens | |
7.6.2.2 | neohesperidin | inhibits the efflux of the P-gp substrate rhodamine 123 in a concentration-dependent manner. Good candidates for the development of novel P-gp/MDR1 reversal agents which may enhance the accumulation and efficacy of chemotherapy agents | Homo sapiens | |
7.6.2.2 | stigmasterol | inhibits the efflux of the P-gp substrate rhodamine 123 in a concentration-dependent manner. Good candidates for the development of novel P-gp/MDR1 reversal agents which may enhance the accumulation and efficacy of chemotherapy agents | Homo sapiens | |
7.6.2.2 | verapamil | - |
Homo sapiens |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
7.6.2.2 | ATP + H2O + rhodamine 123/in | Homo sapiens | - |
ADP + phosphate + rhodamine 123/out | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
7.6.2.2 | Homo sapiens | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
7.6.2.2 | Caco-2 cell | - |
Homo sapiens | - |
7.6.2.2 | CEM-ADR5000 cell | - |
Homo sapiens | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
7.6.2.2 | ATP + H2O + rhodamine 123/in | - |
Homo sapiens | ADP + phosphate + rhodamine 123/out | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
7.6.2.2 | MDR1 | - |
Homo sapiens |
7.6.2.2 | P-glycoprotein | - |
Homo sapiens |
EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|---|
7.6.2.2 | 0.134 | - |
37°C, pH is not specified in the publication. Rhodamine 123 efflux assay, in leukaemia cell line CEM/ADR5000 | Homo sapiens | beta-sitosterol-O-glucoside | |
7.6.2.2 | 0.169 | - |
37°C, pH is not specified in the publication. Rhodamine 123 efflux assay, in leukaemia cell line CEM/ADR5000 | Homo sapiens | neohesperidin | |
7.6.2.2 | 0.174 | - |
37°C, pH is not specified in the publication. Rhodamine 123 efflux assay, in CACO-2 cells | Homo sapiens | neohesperidin | |
7.6.2.2 | 0.195 | - |
37°C, pH is not specified in the publication. Rhodamine 123 efflux assay, in CACO-2 cells | Homo sapiens | hesperidin | |
7.6.2.2 | 0.21 | - |
37°C, pH is not specified in the publication. Rhodamine 123 efflux assay, in leukaemia cell line CEM/ADR5000 | Homo sapiens | stigmasterol | |
7.6.2.2 | 0.22 | - |
37°C, pH is not specified in the publication. Rhodamine 123 efflux assay, in leukaemia cell line CEM/ADR5000 | Homo sapiens | deacetylnomilin | |
7.6.2.2 | 0.23 | - |
37°C, pH is not specified in the publication. Rhodamine 123 efflux assay, in leukaemia cell line CEM/ADR5000 | Homo sapiens | hesperidin | |
7.6.2.2 | 0.285 | - |
37°C, pH is not specified in the publication. Rhodamine 123 efflux assay, in leukaemia cell line CEM/ADR5000 | Homo sapiens | limonin | |
7.6.2.2 | 0.338 | - |
37°C, pH is not specified in the publication. Rhodamine 123 efflux assay, in CACO-2 cells | Homo sapiens | beta-sitosterol-O-glucoside | |
7.6.2.2 | 0.387 | - |
37°C, pH is not specified in the publication. Rhodamine 123 efflux assay, in CACO-2 cells | Homo sapiens | stigmasterol | |
7.6.2.2 | 0.478 | - |
37°C, pH is not specified in the publication. Rhodamine 123 efflux assay, in CACO-2 cells | Homo sapiens | deacetylnomilin | |
7.6.2.2 | 0.52 | - |
37°C, pH is not specified in the publication. Rhodamine 123 efflux assay, in CACO-2 cells | Homo sapiens | limonin |
EC Number | General Information | Comment | Organism |
---|---|---|---|
7.6.2.2 | physiological function | mediates drug efflux from cells and plays a major role in causing multidrug resistance | Homo sapiens |