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Literature summary extracted from
- Primary steps of the Na+-translocating NADH:ubiquinone oxidoreductase catalytic cycle resolved by the ultrafast freeze-quench approach (2009), J. Biol. Chem., 284, 5533-5538.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 7.2.1.1 | NAD+ | competitive inhibitor | Vibrio harveyi |  |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 7.2.1.1 | membrane | - |
Vibrio harveyi | 16020 | - |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 7.2.1.1 | NADH + H+ + ubiquinone + n Na+/in | Vibrio harveyi | Na+-NQR reduction is not limited by the rate of NADH binding | NAD+ + ubiquinol + n Na+/out | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 7.2.1.1 | Vibrio harveyi | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 7.2.1.1 | - |
Vibrio harveyi |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 7.2.1.1 | NADH + H+ + ubiquinone + n Na+/in | Na+-NQR reduction is not limited by the rate of NADH binding | Vibrio harveyi | NAD+ + ubiquinol + n Na+/out | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 7.2.1.1 | Na+-translocating NADH:ubiquinone oxidoreductase | - |
Vibrio harveyi |
| 7.2.1.1 | sodium-translocating NADH:quinone oxidoreductase | - |
Vibrio harveyi |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 7.2.1.1 | FAD | - |
Vibrio harveyi | |
| 7.2.1.1 | FMN | two covalently bound FMNs | Vibrio harveyi | |
| 7.2.1.1 | NADH | - |
Vibrio harveyi | |
| 7.2.1.1 | riboflavin | - |
Vibrio harveyi | |
| 7.2.1.1 | ubiquinone-8 | - |
Vibrio harveyi | |
| 7.2.1.1 | [2Fe-2S]-center | - |
Vibrio harveyi | |
Ki Value [mM]
| EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 7.2.1.1 | 11 | - |
NAD+ | at 30°C, 100 mM KCl, 20 mM HEPES/Tris (pH 7.5) | Vibrio harveyi | |
General Information
| EC Number | General Information | Comment | Organism |
|---|---|---|---|
| 7.2.1.1 | physiological function | Na+-NQR is a component of respiratory chain and generates a redox-driven transmembrane electrochemical Na+ potential | Vibrio harveyi |
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Release 2023.1 (January 2023)
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