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Literature summary extracted from
- Inhibition of aldose reductase prevents growth factor-induced G1-S phase transition through the AKT/phosphoinositide 3-kinase/E2F-1 pathway in human colon cancer cells (2010), Mol. Cancer Ther., 9, 813-824.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.1.1.21 | fidarestat | - |
Homo sapiens |  |
| 1.1.1.21 | additional information | inhibition of the enzyme activity also inhibits the expression of the enzyme protein in xenograft tissue | Homo sapiens | |
| 1.1.1.21 | sorbinil | - |
Homo sapiens | |
| 1.1.1.21 | zopolrestat | - |
Homo sapiens | |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.1.1.21 | DL-glyceraldehyde + NADPH + H+ | Homo sapiens | - |
DL-glycerol + NADP+ | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.1.1.21 | Homo sapiens | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.1.1.21 | colonic cancer cell | - |
Homo sapiens | - |
| 1.1.1.21 | HCT-116 cell | - |
Homo sapiens | - |
| 1.1.1.21 | HT-29 cell | - |
Homo sapiens | - |
| 1.1.1.21 | SW-480 cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.1.1.21 | DL-glyceraldehyde + NADPH + H+ | - |
Homo sapiens | DL-glycerol + NADP+ | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.1.1.21 | aldose reductase | - |
Homo sapiens |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.1.1.21 | NADPH | - |
Homo sapiens | |
Expression
| EC Number | Organism | Comment | Expression |
|---|---|---|---|
| 1.1.1.21 | Homo sapiens | inhibition of the enzyme activity also inhibits the expression of the enzyme protein in xenograft tissue | down |
General Information
| EC Number | General Information | Comment | Organism |
|---|---|---|---|
| 1.1.1.21 | physiological function | inhibition of aldose reductase prevents growth factor-induced G1-S phase transition through the AKT/phosphoinositide 3-kinase/E2F-1 pathway in colon cancer cells. Inhibition of aldose reductasee prevents EGF- and bFGF-induced DNA binding activity and expression of E2F-1 in colon cancer cells, overview | Homo sapiens |
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