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Literature summary extracted from

  • Kato, A.; Yasuko, H.; Goto, H.; Hollinshead, J.; Nash, R.; Adachi, I.
    Inhibitory effect of rhetsinine isolated from Evodia rutaecarpa on aldose reductase activity (2009), Phytomedicine, 16, 258-261.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.21 N2-(2-methylaminobenzoyl)tetrahydro-1H-pyrido[3,4-b]indol-1-one i.e. rhetsinine, from Evodia rutaecarpa hot water extract. Rhetsinine inhibits sorbitol accumulation by 79.3% at 0.1 mM in erythrocytes Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.21 DL-glyceraldehyde + NADPH + H+ Homo sapiens
-
 DL-glycerol + NADP+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.21 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.21 erythrocyte
-
 Homo sapiens
-
1.1.1.21 muscle
-
 Homo sapiens
-
1.1.1.21 retina
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.21 DL-glyceraldehyde + NADPH + H+
-
 Homo sapiens DL-glycerol + NADP+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.21 aldose reductase
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.1.1.21 37
-
 assay at Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.1.1.21 0.0241
-
 pH not specified in the publication, temperature not specified in the publication Homo sapiens N2-(2-methylaminobenzoyl)tetrahydro-1H-pyrido[3,4-b]indol-1-one

General Information

EC Number General Information Comment Organism
1.1.1.21 metabolism aldose reductase plays key roles in the polyol pathway Homo sapiens