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Literature summary extracted from

  • Mhamdi, A.; Mauve, C.; Gouia, H.; Saindrenan, P.; Hodges, M.; Noctor, G.
    Cytosolic NADP-dependent isocitrate dehydrogenase contributes to redox homeostasis and the regulation of pathogen responses in Arabidopsis leaves (2010), Plant Cell Environ., 33, 1112-1123.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.1.1.42 isozyme cICDH is encoded by a single gene Arabidopsis thaliana

Protein Variants

EC Number Protein Variants Comment Organism
1.1.1.42 additional information introduction of an icdh mutation into the cat2 background, in which increased availability of H2O2 causes perturbed redox homeostasis and induction of stress-related genes. Accumulation of oxidized glutathione and pathogen-related responses are enhanced in double cat2 icdh mutants compared to cat2. Single icdh mutants present constitutive induction of PR genes, enhanced resistance to bacteria in icdh, cat2 and cat2 icdh is quantitatively correlated with PR gene expression. However, the effect of icdh in both Col0 and cat2 backgrounds is not associated with enhanced accumulation of salicylic acid, phenotypes, overview Arabidopsis thaliana

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.1.1.42 cytosol isozyme cICDH Arabidopsis thaliana 5829
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.42 isocitrate + NADP+ Arabidopsis thaliana
-
 2-oxoglutarate + NADPH + H+ + CO2
-
 ?
1.1.1.42 isocitrate + NADP+ Arabidopsis thaliana Columbia ecotype
-
 2-oxoglutarate + NADPH + H+ + CO2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.42 Arabidopsis thaliana
-
 gene icdh
-
1.1.1.42 Arabidopsis thaliana Columbia ecotype
-
 gene icdh
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.42 leaf
-
 Arabidopsis thaliana
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.42 isocitrate + NADP+
-
 Arabidopsis thaliana 2-oxoglutarate + NADPH + H+ + CO2
-
 ?
1.1.1.42 isocitrate + NADP+
-
 Arabidopsis thaliana Columbia ecotype 2-oxoglutarate + NADPH + H+ + CO2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.42 cICDH
-
 Arabidopsis thaliana
1.1.1.42 cytosolic NADP-dependent isocitrate dehydrogenase
-
 Arabidopsis thaliana

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.42 NADP+
-
 Arabidopsis thaliana

General Information

EC Number General Information Comment Organism
1.1.1.42 physiological function cICDH is involved in amino acid synthesis, and plays a role in redox signalling linked to pathogen responses, but cICDH is not required for plant development and primary metabolism in optimal growth conditions Arabidopsis thaliana