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Literature summary extracted from

  • Meijer, W.H.; Gidijala, L.; Fekken, S.; Kiel, J.A.; van den Berg, M.A.; Lascaris, R.; Bovenberg, R.A.; van der Klei, I.J.
    Peroxisomes are required for efficient penicillin biosynthesis in Penicillium chrysogenum (2010), Appl. Environ. Microbiol., 76, 5702-5709.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
6.2.1.30 for the visualization of peroxisomes by fluorescence microscopy, the peroxisomal targeting signal 1, PTS1, Ser-Lys-Leu, SKL, is fused to the extreme C-terminus of green fluorescent protein and DsRed, construction of plasmid pGBRH2-GFP-SKL, expression under the control of the strong Penicillium chrysogenum pcbC promoter, or by the lower-level, constitutive Aspergillus nidulans gpdA promoter in strain DS54465, an DELTAhdfA derivative of DS17690, transformation of protoplasts, overview Penicillium chrysogenum

Protein Variants

EC Number Protein Variants Comment Organism
6.2.1.30 additional information generation of peroxisome-deficient, non-oleate-utilizing mutants S2201 to S2204 from Wis54-1255 spores Penicillium chrysogenum

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
6.2.1.30 peroxisome proliferation rates in strain DS17690, overview Penicillium chrysogenum 5777
-
6.2.1.30 peroxisome proliferation rates in strain NRRL1951, overview Penicillium chrysogenum 5777
-
6.2.1.30 peroxisome proliferation rates in strain Wis54-1255, overview Penicillium chrysogenum 5777
-

Organism

EC Number Organism UniProt Comment Textmining
6.2.1.30 Penicillium chrysogenum
-
-
-
6.2.1.30 Penicillium chrysogenum
-
 a strain with increased penicillin production rate
-
6.2.1.30 Penicillium chrysogenum NRRL1951
-
-
-
6.2.1.30 Penicillium chrysogenum NRRL1951
-
 a strain with increased penicillin production rate
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
6.2.1.30 hypha
-
 Penicillium chrysogenum
-
6.2.1.30 spore germinating Penicillium chrysogenum
-

Synonyms

EC Number Synonyms Comment Organism
6.2.1.30 PCL
-
 Penicillium chrysogenum
6.2.1.30 phenylacetyl CoA ligase
-
 Penicillium chrysogenum

Expression

EC Number Organism Comment Expression
6.2.1.30 Penicillium chrysogenum Dnm1 and oleate suppress PCL and penicillin production down

General Information

EC Number General Information Comment Organism
6.2.1.30 metabolism PCL is essentially involved in the pathway of penicillin biosynthesis, overview. Conditions that lead to peroxisome proliferation but simultaneously interfere with the normal physiology of the cell may be detrimental to antibiotic production Penicillium chrysogenum
6.2.1.30 additional information conditions that lead to peroxisome proliferation but simultaneously interfere with the normal physiology of the cell may be detrimental for antibiotic production Penicillium chrysogenum
6.2.1.30 additional information conditions that lead to peroxisome proliferation but simultaneously interfere with the normal physiology of the cell may be detrimental for antibiotic production. The number of peroxisomes in a dnm1 overexpression strain variant is enhanced relative to those of wild-type controls Penicillium chrysogenum
6.2.1.30 physiological function PCL is a side-chain precursor activation enzyme essentially involved in the pathway of penicillin biosynthesis, overview Penicillium chrysogenum