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Literature summary extracted from

  • Lemma, E.; Simon, J.; Schagger, H.; Kroger, A.
    Properties of the menaquinol oxidase (Qox) and of qox deletion mutants of Bacillus subtilis (1995), Arch. Microbiol., 163, 432-438.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
7.1.1.5 2-(n-heptyl)-4-hydroxyquinoline-N-oxide
-
Bacillus subtilis
7.1.1.5 antimycin A more than 10fold less effective than 2-(n-heptyl)-4-hydroxyquinoline-N-oxide, 39% residual activity at 0.01 mM Bacillus subtilis
7.1.1.5 cyanide 47% residual activity at 0.5 mM Bacillus subtilis
7.1.1.5 Myxothiazol more than 10fold less effective than 2-(n-heptyl)-4-hydroxyquinoline-N-oxide, 45% residual activity at 0.01 mM Bacillus subtilis
7.1.1.5 Stigmatellin more than 10fold less effective than 2-(n-heptyl)-4-hydroxyquinoline-N-oxide, 39% residual activity at 0.01 mM Bacillus subtilis

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
7.1.1.5 membrane
-
Bacillus subtilis 16020
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
7.1.1.5 13686
-
1 * 33640 + 1 * 73834 + 1 * 22670 + 1 * 13686, subunits QoxA, QoxB, QoxC and QoxD, calculated from sequence of cDNA Bacillus subtilis
7.1.1.5 15000
-
1 * 36000 + 1 * 54000 + 1 * 20000 + 1 * 15000, subunits QoxA, QoxB, QoxC and QoxD, SDS-PAGE Bacillus subtilis
7.1.1.5 20000
-
1 * 36000 + 1 * 54000 + 1 * 20000 + 1 * 15000, subunits QoxA, QoxB, QoxC and QoxD, SDS-PAGE Bacillus subtilis
7.1.1.5 22670
-
1 * 33640 + 1 * 73834 + 1 * 22670 + 1 * 13686, subunits QoxA, QoxB, QoxC and QoxD, calculated from sequence of cDNA Bacillus subtilis
7.1.1.5 33640
-
1 * 33640 + 1 * 73834 + 1 * 22670 + 1 * 13686, subunits QoxA, QoxB, QoxC and QoxD, calculated from sequence of cDNA Bacillus subtilis
7.1.1.5 36000
-
1 * 36000 + 1 * 54000 + 1 * 20000 + 1 * 15000, subunits QoxA, QoxB, QoxC and QoxD, SDS-PAGE Bacillus subtilis
7.1.1.5 54000
-
1 * 36000 + 1 * 54000 + 1 * 20000 + 1 * 15000, subunits QoxA, QoxB, QoxC and QoxD, SDS-PAGE Bacillus subtilis
7.1.1.5 73834
-
1 * 33640 + 1 * 73834 + 1 * 22670 + 1 * 13686, subunits QoxA, QoxB, QoxC and QoxD, calculated from sequence of cDNA Bacillus subtilis
7.1.1.5 144000
-
calculated from sequence of cDNA Bacillus subtilis

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
7.1.1.5 menaquinol + O2 Bacillus subtilis
-
menaquinone + H2O
-
?
7.1.1.5 menaquinol + O2 Bacillus subtilis W23
-
menaquinone + H2O
-
?

Organism

EC Number Organism UniProt Comment Textmining
7.1.1.5 Bacillus subtilis
-
-
-
7.1.1.5 Bacillus subtilis W23
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
7.1.1.5 culture condition:glucose-grown cell
-
Bacillus subtilis
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
7.1.1.5 2 2,3-dimethyl-1,4-naphthoquinol + O2 + n H+[side 1] best substrate Bacillus subtilis 2 2,3-dimethyl-1,4-naphthoquinone + 2 H2O + n H+[side 2]
-
?
7.1.1.5 2 2,3-dimethyl-1,4-naphthoquinol + O2 + n H+[side 1] best substrate Bacillus subtilis W23 2 2,3-dimethyl-1,4-naphthoquinone + 2 H2O + n H+[side 2]
-
?
7.1.1.5 menadiol + O2 + n H+[side 1]
-
Bacillus subtilis menadione + H2O + n H+[side 2]
-
?
7.1.1.5 menadiol + O2 + n H+[side 1]
-
Bacillus subtilis W23 menadione + H2O + n H+[side 2]
-
?
7.1.1.5 menaquinol + O2
-
Bacillus subtilis menaquinone + H2O
-
?
7.1.1.5 menaquinol + O2
-
Bacillus subtilis W23 menaquinone + H2O
-
?
7.1.1.5 additional information no activity with 1,4-naphthoquinol, N,N,N',N'-tetramethyl-1,4-phenylenediamine plus ascorbate or reduced cytochrome c Bacillus subtilis ?
-
?
7.1.1.5 additional information no activity with 1,4-naphthoquinol, N,N,N',N'-tetramethyl-1,4-phenylenediamine plus ascorbate or reduced cytochrome c Bacillus subtilis W23 ?
-
?

Subunits

EC Number Subunits Comment Organism
7.1.1.5 heterotetramer 1 * 33640 + 1 * 73834 + 1 * 22670 + 1 * 13686, subunits QoxA, QoxB, QoxC and QoxD, calculated from sequence of cDNA Bacillus subtilis
7.1.1.5 heterotetramer 1 * 36000 + 1 * 54000 + 1 * 20000 + 1 * 15000, subunits QoxA, QoxB, QoxC and QoxD, SDS-PAGE Bacillus subtilis

Synonyms

EC Number Synonyms Comment Organism
7.1.1.5 menaquinol oxidase (aa3-600)
-
Bacillus subtilis
7.1.1.5 Qox
-
Bacillus subtilis

Cofactor

EC Number Cofactor Comment Organism Structure
7.1.1.5 cytochrome the enzyme contains 7 mol cytochrome aa 3 per g protein which corresponds to 2 mol heme A per mol enzyme Bacillus subtilis