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Literature summary extracted from

  • Lohman, G.J.; Stubbe, J.
    Inactivation of Lactobacillus leichmannii ribonucleotide reductase by 2',2'-difluoro-2'-deoxycytidine 5'-triphosphate: covalent modification (2010), Biochemistry, 49, 1404-1417.
    View publication on PubMedView publication on EuropePMC

Protein Variants

EC Number Protein Variants Comment Organism
1.17.4.2 C119S site-directed mutagenesis Lactobacillus leichmannii

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.17.4.2 2',2'-difluoro-2'-deoxycytidine 5'-triphosphate F2CTP, a clinically used anti-cancer drug, synthesis, overview. Causes rapid enzyme inactivation through covalent modification, mechanism of inactivation, analysis by mass spectrometry and radio- or deuterium-labeled compounds, overview. C119 is involved in the reaction Lactobacillus leichmannii
1.17.4.2 2'-chloro-2'-deoxy-UTP
-
 Lactobacillus leichmannii

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.17.4.2 76000
-
-
 Lactobacillus leichmannii

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.17.4.2 additional information Lactobacillus leichmannii RTPR catalyzes the conversion of nucleoside triphosphates to deoxynucleotides using adenosylcobalamin as a cofactor ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.17.4.2 Lactobacillus leichmannii
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.17.4.2 CTP + adenosylcobalamin
-
 Lactobacillus leichmannii ?
-
 ?
1.17.4.2 additional information RTPR catalyzes the conversion of nucleoside triphosphates to deoxynucleotides using adenosylcobalamin as a cofactor Lactobacillus leichmannii ?
-
 ?

Subunits

EC Number Subunits Comment Organism
1.17.4.2 monomer 1 * 76000 Lactobacillus leichmannii

Synonyms

EC Number Synonyms Comment Organism
1.17.4.2 class II RNR
-
 Lactobacillus leichmannii
1.17.4.2 nucleoside triphosphate reductase
-
 Lactobacillus leichmannii
1.17.4.2 ribonucleotide reductase
-
 Lactobacillus leichmannii
1.17.4.2 RNR
-
 Lactobacillus leichmannii
1.17.4.2 RTPR
-
 Lactobacillus leichmannii

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.17.4.2 37
-
 assay at Lactobacillus leichmannii

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.17.4.2 7.5
-
 assay at Lactobacillus leichmannii

Cofactor

EC Number Cofactor Comment Organism Structure
1.17.4.2 adenosylcobalamin
-
 Lactobacillus leichmannii