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Literature summary extracted from

  • Kim, J.; Kershner, J.P.; Novikov, Y.; Shoemaker, R.K.; Copley, S.D.
    Three serendipitous pathways in E. coli can bypass a block in pyridoxal-5'-phosphate synthesis (2010), Mol. Syst. Biol., 6, 436.
    View publication on PubMedView publication on EuropePMC

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
4.1.2.48 0.027
-
 L-4-hydroxythreonine pH 8.0, 25°C Escherichia coli
4.1.2.48 0.052
-
 L-allo-threonine pH 8.0, 25°C Escherichia coli
4.1.2.48 4
-
 L-threonine pH 8.0, 25°C Escherichia coli

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.1.2.48 glycine + glycolaldehyde Escherichia coli low-specificity L-threonine aldolase is involved in a serendipitous pathway that converts 3-phosphohydroxypyruvate, an intermediate in the serine biosynthesis pathway, to L-4-phosphohydroxythreonine, an intermediate in the pyridoxal-5'-phosphate synthesis pathway in a strain of Escherichia coli that lacks 4-phosphoerythronate dehydrogenase L-4-hydroxythreonine
-
 r

Organism

EC Number Organism UniProt Comment Textmining
4.1.2.48 Escherichia coli
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.1.2.48 glycine + glycolaldehyde low-specificity L-threonine aldolase is involved in a serendipitous pathway that converts 3-phosphohydroxypyruvate, an intermediate in the serine biosynthesis pathway, to L-4-phosphohydroxythreonine, an intermediate in the pyridoxal-5'-phosphate synthesis pathway in a strain of Escherichia coli that lacks 4-phosphoerythronate dehydrogenase Escherichia coli L-4-hydroxythreonine
-
 r
4.1.2.48 L-4-hydroxythreonine cleavage of L-4-hydroxythreonine is as efficient as cleavage of L-allo-threonine Escherichia coli glycine + glycolaldehyde
-
 r
4.1.2.48 L-allo-threonine
-
 Escherichia coli glycine + acetaldehyde
-
 r
4.1.2.48 L-threonine
-
 Escherichia coli glycine + acetaldehyde
-
 r

Synonyms

EC Number Synonyms Comment Organism
4.1.2.48 LtaE
-
 Escherichia coli

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
4.1.2.48 25
-
 assay at Escherichia coli

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
4.1.2.48 1.1
-
 L-threonine pH 8.0, 25°C Escherichia coli
4.1.2.48 1.44
-
 L-4-hydroxythreonine pH 8.0, 25°C Escherichia coli
4.1.2.48 3.2
-
 L-allo-threonine pH 8.0, 25°C Escherichia coli

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
4.1.2.48 8
-
 assay at Escherichia coli

General Information

EC Number General Information Comment Organism
4.1.2.48 physiological function low-specificity L-threonine aldolase is involved in a serendipitous pathway that converts 3-phosphohydroxypyruvate, an intermediate in the serine biosynthesis pathway, to L-4-phosphohydroxythreonine, an intermediate in the pyridoxal-5'-phosphate synthesis pathway in a strain of Escherichia coli that lacks 4-phosphoerythronate dehydrogenase Escherichia coli

kcat/KM [mM/s]

EC Number kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
4.1.2.48 2.8
-
 L-threonine pH 8.0, 25°C Escherichia coli
4.1.2.48 5.3
-
 L-4-hydroxythreonine pH 8.0, 25°C Escherichia coli
4.1.2.48 6.2
-
 L-allo-threonine pH 8.0, 25°C Escherichia coli