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Literature summary extracted from

  • Oudin, A.; Courtois, M.; Rideau, M.; Clastre, M.
    The iridoid pathway in Catharanthus roseus alkaloid biosynthesis (2007), Phytochem. Rev., 6, 259-276.
No PubMed abstract available

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.14.14.83
-
 Catharanthus roseus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.14.83 geraniol + [reduced NADPH-hemoprotein reductase] + O2 Catharanthus roseus
-
 10-hydroxygeraniol + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
1.14.14.83 nerol + [reduced NADPH-hemoprotein reductase] + O2 Catharanthus roseus cis-isomer of geraniol 10-hydroxynerol + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.14.83 Catharanthus roseus
-
 two constituents of geraniol 10-hydroxylase, gene CYP76B6
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.14.83 geraniol + [reduced NADPH-hemoprotein reductase] + O2
-
 Catharanthus roseus 10-hydroxygeraniol + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
1.14.14.83 nerol + [reduced NADPH-hemoprotein reductase] + O2 cis-isomer of geraniol Catharanthus roseus 10-hydroxynerol + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.14.83 CYP76B6 protein
-
 Catharanthus roseus
1.14.14.83 G10H
-
 Catharanthus roseus

Expression

EC Number Organism Comment Expression
1.14.14.83 Catharanthus roseus G10H is repressed by ketonazole down
1.14.14.83 Catharanthus roseus various hormones and elicitors upregulate G10H and the monoterpene alkaloid biosynthesis pathways. G10H activity is induced by phenobarbital up

General Information

EC Number General Information Comment Organism
1.14.14.83 metabolism the enzyme is one of the key enzymes of the biosynthesis of monoterpene indole alkaloids that originate from the coupling of the indole and the iridoid pathways. Overview of metabolic pathways leading to the biosynthesis of monoterpene indole alkaloids and their metabolic regulation Catharanthus roseus
1.14.14.83 additional information geraniol 10-hydroxylase is a cytochrome P450 monooxygenase. It consists of a reductase and a monooxygenase. The cytochrome P450 reductase, EC 1.6.2.4, is a membrane-bound flavoprotein, which transfers electrons from NADPH to the cytochrome P450 monooxygenase, CPR requires the cofactors FMN, FAD and NADPH Catharanthus roseus