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Literature summary extracted from

  • Veit, K.; Ehlers, C.; Schmitz, R.
    Effects of nitrogen and carbon sources on transcription of soluble methyltransferases in Methanosarcina mazei strain Gö1 (2005), J. Bacteriol., 187, 6147-6154.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.1.1.248 gene mtmB1and mtmB2C2, operon encoding MMA methylamine methyltransferase, quantitative RT-PCR expression analysis, comparison with other methylamine methyltransferases, overview. Transcriptional regulation of genes encoding methylamine methyltransferases in cells growing on Ttrimethyamine or methanol in the presence of ammonium, overview Methanosarcina mazei
2.1.1.249 genes mtbB1 and mtbB2C2, operon encoding DMA methylamine methyltransferase, quantitative RT-PCR expression analysis, comparison with other methylamine methyltransferases, overview. Transcriptional regulation of genes encoding methylamine methyltransferases in cells growing on trimethylamine or methanol in the presence of ammonium, overview Methanosarcina mazei
2.1.1.250 gene mttB1C1, operon encoding TMA methylamine methyltransferase, quantitative RT-PCR expression analysis, comparison with other methylamine methyltransferases, overview. Transcriptional regulation of genes encoding methylamine methyltransferases (MT) in cells growing on TMA or methanol in the presence of ammonium, overview Methanosarcina mazei
2.1.1.250 gene mttB2C2, operon encoding TMA methylamine methyltransferase, quantitative RT-PCR expression analysis, comparison with other methylamine methyltransferases, overview. Transcriptional regulation of genes encoding methylamine methyltransferases (MT) in cells growing on TMA or methanol in the presence of ammonium, overview Methanosarcina mazei

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.1.248 methylamine + a [Co(I) methylamine-specific corrinoid protein] Methanosarcina mazei
-
 a [methyl-Co(III) methylamine-specific corrinoid protein] + ammonia
-
 ?
2.1.1.248 methylamine + a [Co(I) methylamine-specific corrinoid protein] Methanosarcina mazei Goe1
-
 a [methyl-Co(III) methylamine-specific corrinoid protein] + ammonia
-
 ?
2.1.1.249 dimethylamine + a [Co(I) dimethylamine-specific corrinoid protein] Methanosarcina mazei
-
 a [methyl-Co(III) dimethylamine-specific corrinoid protein] + methylamine
-
 ?
2.1.1.249 dimethylamine + a [Co(I) dimethylamine-specific corrinoid protein] Methanosarcina mazei Goe1
-
 a [methyl-Co(III) dimethylamine-specific corrinoid protein] + methylamine
-
 ?
2.1.1.250 trimethylamine + a [Co(I) trimethylamine-specific corrinoid protein] Methanosarcina mazei
-
 a [methyl-Co(III) trimethylamine-specific corrinoid protein] + dimethylamine
-
 ?
2.1.1.250 trimethylamine + a [Co(I) trimethylamine-specific corrinoid protein] Methanosarcina mazei Goe1
-
 a [methyl-Co(III) trimethylamine-specific corrinoid protein] + dimethylamine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.248 Methanosarcina mazei
-
 DSM 3647, genes mtmB1C1 and mtmB2C2
-
2.1.1.248 Methanosarcina mazei Goe1
-
 DSM 3647, genes mtmB1C1 and mtmB2C2
-
2.1.1.249 Methanosarcina mazei
-
 DSM 3647, genes mtbB1 and mtbB2C2
-
2.1.1.249 Methanosarcina mazei Goe1
-
 DSM 3647, genes mtbB1 and mtbB2C2
-
2.1.1.250 Methanosarcina mazei P58973 DSM 3647, gene mttB1C1
-
2.1.1.250 Methanosarcina mazei P58974 DSM 3647, gene mttB2C2
-
2.1.1.250 Methanosarcina mazei Goe1 P58973 DSM 3647, gene mttB1C1
-
2.1.1.250 Methanosarcina mazei Goe1 P58974 DSM 3647, gene mttB2C2
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.248 methylamine + a [Co(I) methylamine-specific corrinoid protein]
-
 Methanosarcina mazei a [methyl-Co(III) methylamine-specific corrinoid protein] + ammonia
-
 ?
2.1.1.248 methylamine + a [Co(I) methylamine-specific corrinoid protein]
-
 Methanosarcina mazei Goe1 a [methyl-Co(III) methylamine-specific corrinoid protein] + ammonia
-
 ?
2.1.1.249 dimethylamine + a [Co(I) dimethylamine-specific corrinoid protein]
-
 Methanosarcina mazei a [methyl-Co(III) dimethylamine-specific corrinoid protein] + methylamine
-
 ?
2.1.1.249 dimethylamine + a [Co(I) dimethylamine-specific corrinoid protein]
-
 Methanosarcina mazei Goe1 a [methyl-Co(III) dimethylamine-specific corrinoid protein] + methylamine
-
 ?
2.1.1.250 trimethylamine + a [Co(I) trimethylamine-specific corrinoid protein]
-
 Methanosarcina mazei a [methyl-Co(III) trimethylamine-specific corrinoid protein] + dimethylamine
-
 ?
2.1.1.250 trimethylamine + a [Co(I) trimethylamine-specific corrinoid protein]
-
 Methanosarcina mazei Goe1 a [methyl-Co(III) trimethylamine-specific corrinoid protein] + dimethylamine
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.1.1.248 mtmB1
-
 Methanosarcina mazei
2.1.1.250 MMA methyltransferase 1
-
 Methanosarcina mazei
2.1.1.250 MMA methyltransferase 2
-
 Methanosarcina mazei
2.1.1.250 mttB1C1
-
 Methanosarcina mazei
2.1.1.250 mttB2C2
-
 Methanosarcina mazei

Expression

EC Number Organism Comment Expression
2.1.1.248 Methanosarcina mazei transcription of the mtmB1C1 operon is not affected by the nitrogen source but appears to be increased when trimethylamine is the sole carbon and energy source. Under nitrogen limitation, a 543fold up-regulation of the mtmB2C2 operon encoding MMA methyltransferase 2 is obtained when methanol was used as carbon source, whereas transcription of the homologous mtmB1C1 operon occurs at a constant level independently of the nitrogen source up
2.1.1.250 Methanosarcina mazei transcription of the mtmB1C1 operon is not affected by the nitrogen source but appears to be increased when trimethylamine is the sole carbon and energy source. Transcription of the homologous mtmB1C1 operon occurs at a constant level independently of the nitrogen source up
2.1.1.250 Methanosarcina mazei under nitrogen limitation, a 543fold up-regulation of the mtmB2C2 operon, encoding MMA methyltransferase 2, is obtained when methanol is used as carbon source up

General Information

EC Number General Information Comment Organism
2.1.1.248 metabolism when growing on trimethylamine, nitrogen fixation does not occur in the cells, indicating that ammonium released during trimethylamine degradation is sufficient to serve as a nitrogen source and represses nif gene induction, transcriptional regulation of soluble methyltransferases, which catalyze the initial step of methylamine consumption by methanogenesis, in response to different carbon and nitrogen sources, overview. Regulation of soluble methyltransferases in response to different nitrogen and carbon sources, overview Methanosarcina mazei
2.1.1.249 metabolism when growing on trimethylamine, nitrogen fixation does not occur in the cells, indicating that ammonium released during trimethylamine degradation is sufficient to serve as a nitrogen source and represses nif gene induction, transcriptional regulation of soluble methyltransferases, which catalyze the initial step of methylamine consumption by methanogenesis, in response to different carbon and nitrogen sources, overview. Transcription of the operon encoding DMA methyltransferase is not regulated in response to the nitrogen source. Regulation of soluble methyltransferases in response to different nitrogen and carbon sources, overview Methanosarcina mazei
2.1.1.250 metabolism when growing on trimethylamine, nitrogen fixation does not occur in the cells, indicating that ammonium released during trimethylamine degradation is sufficient to serve as a nitrogen source and represses nif gene induction, transcriptional regulation of soluble methyltransferases, which catalyze the initial step of methylamine consumption by methanogenesis, in response to different carbon and nitrogen sources, overview. Transcription of the operon encoding TMA methyltransferase is not regulated in response to the nitrogen source. Regulation of soluble methyltransferases in response to different nitrogen and carbon sources, overview Methanosarcina mazei