EC Number | Protein Variants | Comment | Organism |
---|---|---|---|
3.2.1.18 | additional information | construction of insertion mutant enzyme by deleting the 20-aa segment, residues 49-68, from the stalk region of 2009H1N1 neuraminidase, and inserting this segment, designated 09s60, into the stalk region of H5N1 neuraminidase | influenza A virus |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
3.2.1.18 | oseltamivir | the robust neuraminidase activity of the 2009H1N1 virus is responsible for the high sensitivity of the virus to oseltamivir | influenza A virus |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.2.1.18 | influenza A virus | - |
- |
- |
3.2.1.18 | influenza A virus A/California/05/2009/H1N1 | - |
- |
- |
3.2.1.18 | influenza A virus A/Hong Kong/156/97/H5N1 | - |
- |
- |
EC Number | Posttranslational Modification | Comment | Organism |
---|---|---|---|
3.2.1.18 | glycoprotein | - |
influenza A virus |
3.2.1.18 | glycoprotein | glycosylation pattern of insertion mutant 09N1 | influenza A virus |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|
EC Number | Subunits | Comment | Organism |
---|---|---|---|
3.2.1.18 | oligomer | the wild-type neuraminidase from this virus occurs primarily as a 120 kDa dimer but also as a tetramer and, in lesser amounts, as a 60 kDa monomer. The molecular masses of AH N1 and AH N1+09s60 expressed in pseudoparticle-infected 293T cells are 50 kDa and 60 kDa, respectively | influenza A virus |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
3.2.1.18 | neuraminidase | - |
influenza A virus |
EC Number | General Information | Comment | Organism |
---|---|---|---|
3.2.1.18 | malfunction | neuraminidase insertion mutant virus shows increased particles formation, in pseudotyped particles system, activity compared to the wild-type virus. Compared with the wild-type AH N1, from A/California/05/2009/H1N1, the wild-type 09N1 exhibits higher neuraminidase activity and releases more pseudoparticles. Deletion/insertion of the 09s60 segment does not alter this relationship. The infectivity of pseudoparticles harboring neuraminidase in combination with the hemagglutinin from HPAI H5N1 (AH H5) is decreased by insertion of 09s60 into AH N1 and is increased by deletion of 09s60 from 09N1, the mutation also alters the oligomeric structure, overview | influenza A virus |
3.2.1.18 | malfunction | neuraminidase insertion mutant virus shows increased particles formation, in pseudotyped particles system, activity compared to the wild-type virus. Compared with the wild-type AH N1, the wild-type 09N1 exhibits higher neuraminidase activity and releases more pseudoparticles. Deletion/insertion of the 09s60 segment does not alter this relationship. The infectivity of pseudoparticles harboring neuraminidase in combination with the hemagglutinin from HPAI H5N1 (AH H5, from A/Hong Kong/156/97/H5N1) is decreased by insertion of 09s60 into AH N1 and is increased by deletion of 09s60 from 09N1, the mutation also alters the oligomeric structure, overview | influenza A virus |