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Literature summary extracted from

  • Ushijima, Y.; Inoue, Y.H.; Konishi, T.; Kitazawa, D.; Yoshida, H.; Shimaji, K.; Kimura, H.; Yamaguchi, M.
    Roles of histone H3K9 methyltransferases during Drosophila spermatogenesis (2012), Chromosome Res., 20, 319-331.
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.1.1.355 cytoplasm
-
 Drosophila melanogaster 5737
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.1.1.355 180000
-
 x * 180000, enzyme form dG9a, SDS-PAGE Drosophila melanogaster

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.355 Drosophila melanogaster
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.1.1.355 testis
-
 Drosophila melanogaster
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.355 S-adenosyl-L-methionine + histone H3(K9) SETDB1 is mainly responsible for mono- and trimethylation of histone H3 lysine 9 and SU (VAR)3-9 for monomethylation of histone H3 lysine 9 during spermatogenesis Drosophila melanogaster S-adenosyl-L-homocysteine + ?
-
 ?

Subunits

EC Number Subunits Comment Organism
2.1.1.355 ? x * 180000, enzyme form dG9a, SDS-PAGE Drosophila melanogaster

Synonyms

EC Number Synonyms Comment Organism
2.1.1.355 dG9a
-
 Drosophila melanogaster
2.1.1.355 H3K9-specific histone methyltransferase
-
 Drosophila melanogaster
2.1.1.355 histone H3K9 methyltransferase
-
 Drosophila melanogaster
2.1.1.355 HMTase
-
 Drosophila melanogaster
2.1.1.355 SETDB1
-
 Drosophila melanogaster
2.1.1.355 SU (VAR)3-9
-
 Drosophila melanogaster

General Information

EC Number General Information Comment Organism
2.1.1.355 physiological function SETDB1 is mainly responsible for mono- and trimethylation of histone H3 lysine 9 and SU (VAR)3-9 for monomethylation of histone H3 lysine 9 during spermatogenesis. Enzyme form dG9a plays no apparent role for histone H3 lysine 9 methylation during spermatogenesis and spermiogenesis Drosophila melanogaster