EC Number | Cloned (Comment) | Organism |
---|---|---|
2.4.1.17 | - |
Homo sapiens |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
2.4.1.17 | 0.007 | - |
ketoconazole | isoform UGT1A4, pH 7.4, 37°C | Homo sapiens | |
2.4.1.17 | 0.028 | - |
bifonazole | isoform UGT1A4, pH 7.4, 37°C | Homo sapiens | |
2.4.1.17 | 0.035 | - |
sulconazole | isoform UGT1A4, pH 7.4, 37°C | Homo sapiens | |
2.4.1.17 | 0.059 | - |
miconazole | isoform UGT1A4, pH 7.4, 37°C | Homo sapiens | |
2.4.1.17 | 0.115 | - |
econazole | isoform UGT1A4, pH 7.4, 37°C | Homo sapiens | |
2.4.1.17 | 0.124 | - |
tioconazole | isoform UGT1A4, pH 7.4, 37°C | Homo sapiens | |
2.4.1.17 | 0.261 | - |
alprazolam | isoform UGT1A4, pH 7.4, 37°C | Homo sapiens | |
2.4.1.17 | 1.13 | - |
voriconazole | isoform UGT1A4, pH 7.4, 37°C | Homo sapiens | |
2.4.1.17 | 1.667 | - |
fluconazole | isoform UGT2B7, pH 7.4, 37°C | Homo sapiens |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
2.4.1.17 | microsome | - |
Homo sapiens | - |
- |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.4.1.17 | Homo sapiens | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
2.4.1.17 | liver | - |
Homo sapiens | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.4.1.17 | alprazolam + UDP-alpha-D-glucuronate | - |
Homo sapiens | alprazolam D-glucuronate + UDP | - |
? | |
2.4.1.17 | bifonazole + UDP-alpha-D-glucuronate | - |
Homo sapiens | bifonazole D-glucuronate + UDP | - |
? | |
2.4.1.17 | econazole + UDP-alpha-D-glucuronate | - |
Homo sapiens | econazole D-glucuronate + UDP | - |
? | |
2.4.1.17 | fluconazole + UDP-alpha-D-glucuronate | - |
Homo sapiens | fluconazole D-glucuronate + UDP | - |
? | |
2.4.1.17 | itraconazole + UDP-alpha-D-glucuronate | - |
Homo sapiens | ? | - |
? | |
2.4.1.17 | ketoconazole + UDP-alpha-D-glucuronate | - |
Homo sapiens | ? | - |
? | |
2.4.1.17 | miconazole + UDP-alpha-D-glucuronate | - |
Homo sapiens | miconazole D-glucuronate + UDP | - |
? | |
2.4.1.17 | additional information | UGT1A4 is the main enzyme involved in the metabolism of all compounds tested except for fluconazole, which is mainly metabolized by UGT2B7, probably mediating its O-glucuronide metabolism. UGT1A3 is also involved in the metabolism of all imidazoles but not triazoles | Homo sapiens | ? | - |
? | |
2.4.1.17 | sulconazole + UDP-alpha-D-glucuronate | - |
Homo sapiens | sulconazole D-glucuronate + UDP | - |
? | |
2.4.1.17 | tioconazole + UDP-alpha-D-glucuronate | - |
Homo sapiens | tioconazole D-glucuronate + UDP | - |
? | |
2.4.1.17 | voriconazole + UDP-alpha-D-glucuronate | - |
Homo sapiens | voriconazole D-glucuronate + UDP | - |
? |