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Literature summary extracted from

  • Ardehali, M.B.; Mei, A.; Zobeck, K.L.; Caron, M.; Lis, J.T.; Kusch, T.
    Drosophila Set1 is the major histone H3 lysine 4 trimethyltransferase with role in transcription (2011), EMBO J., 30, 2817-2828.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.1.1.354 expressed in S2 cells Drosophila melanogaster

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.1.1.354 632800
-
 x * 632800, all dSet1-complex subunits, calculated from amino acid sequence Drosophila melanogaster
2.1.1.354 670000
-
 x * 670000, all dSet1-complex subunits, SDS-PAGE Drosophila melanogaster

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.354 Drosophila melanogaster
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.1.1.354
-
 Drosophila melanogaster

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.354 S-adenosyl-L-methionine + histone H3(K4) H3K4 methyltransferase dSet1 is predominantly responsible for histone H3(K4) trimethylation Drosophila melanogaster ?
-
 ?

Subunits

EC Number Subunits Comment Organism
2.1.1.354 ? x * 632800, all dSet1-complex subunits, calculated from amino acid sequence Drosophila melanogaster
2.1.1.354 ? x * 670000, all dSet1-complex subunits, SDS-PAGE Drosophila melanogaster

Synonyms

EC Number Synonyms Comment Organism
2.1.1.354 H3K4 methyltransferase
-
 Drosophila melanogaster
2.1.1.354 histone H3 lysine 4 trimethyltransferase
-
 Drosophila melanogaster
2.1.1.354 SET1
-
 Drosophila melanogaster

General Information

EC Number General Information Comment Organism
2.1.1.354 physiological function Drosophila Set1 is the major histone H3 lysine 4 trimethyltransferase with role in transcription. dSet1-dependent histone H3 lysine 4 trimethylation is responsible for the generation of a chromatin structure at active promoters that ensures optimal polymerase II release into productive elongation Drosophila melanogaster