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Literature summary extracted from

  • Murakami, M.; Shibuya, K.; Nakayama, T.; Nishino, T.; Yoshimura, T.; Hemmi, H.
    Geranylgeranyl reductase involved in the biosynthesis of archaeal membrane lipids in the hyperthermophilic archaeon Archaeoglobus fulgidus (2007), FEBS J., 274, 805-814.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.3.7.11 expression in Escherichia coli with a polyhistidine-tag at its N-terminus Archaeoglobus fulgidus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.3.7.11 46000
-
 x * 46000, SDS-PAGE Archaeoglobus fulgidus
1.3.7.11 46978
-
 x * 46978, calculated from sequence Archaeoglobus fulgidus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.3.7.11 2,3-bis-O-geranylgeranyl-sn-glycerol 1-phosphate + reduced acceptor Archaeoglobus fulgidus the enzyme is involved in the biosynthesis of archaeal membrane lipids 2,3-bis-O-phytanyl-sn-glycerol 1-phosphate + acceptor
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.3.7.11 Archaeoglobus fulgidus O29786
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.3.7.11
-
 Archaeoglobus fulgidus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.7.11 2,3-bis-O-geranylgeranyl-sn-glycerol 1-phosphate + reduced acceptor the enzyme is involved in the biosynthesis of archaeal membrane lipids Archaeoglobus fulgidus 2,3-bis-O-phytanyl-sn-glycerol 1-phosphate + acceptor
-
 ?
1.3.7.11 2,3-bis-O-geranylgeranyl-sn-glycerol 1-phosphate + reduced acceptor the enzyme shows a preference for 2,3-di-O-geranylgeranylglyceryl phosphate over 3-O-geranylgeranylglyceryl phosphate and geranylgeranyl diphosphate in vitro Archaeoglobus fulgidus 2,3-bis-O-phytanyl-sn-glycerol 1-phosphate + acceptor
-
 ?
1.3.7.11 3-O-geranylgeranyl-sn-glycerol 1-phosphate + reduced acceptor the enzyme shows a preference for 2,3-di-O-geranylgeranylglyceryl phosphate over 3-O-geranylgeranylglyceryl phosphate and geranylgeranyl diphosphate in vitro Archaeoglobus fulgidus ?
-
 ?
1.3.7.11 geranylgeranyl diphosphate + reduced acceptor the enzyme shows a preference for 2,3-di-O-geranylgeranylglyceryl phosphate over 3-O-geranylgeranylglyceryl phosphate and geranylgeranyl diphosphate in vitro Archaeoglobus fulgidus ?
-
 ?

Subunits

EC Number Subunits Comment Organism
1.3.7.11 ? x * 46000, SDS-PAGE Archaeoglobus fulgidus
1.3.7.11 ? x * 46978, calculated from sequence Archaeoglobus fulgidus

Synonyms

EC Number Synonyms Comment Organism
1.3.7.11 AF0464
-
 Archaeoglobus fulgidus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.3.7.11 55
-
 assay at Archaeoglobus fulgidus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.3.7.11 7.5
-
 assay at Archaeoglobus fulgidus

Cofactor

EC Number Cofactor Comment Organism Structure
1.3.7.11 FAD flavoenzyme, contains noncovalently bound FAD Archaeoglobus fulgidus
1.3.7.11 additional information the enzyme requires sodium dithionite as the electron donor for activity in vitro. In the presence of NADPH (the preferred electron donor for plant homologues), the enzyme reaction does not proceed Archaeoglobus fulgidus