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Literature summary extracted from
- Functional characterization of the oxaloacetase encoding gene and elimination of oxalate formation in the beta-lactam producer Penicillium chrysogenum (2011), Fungal Genet. Biol., 48, 831-839.
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 3.7.1.1 | gene Pc22g24830, DNA and amino acid sequence determination and analysis, cloning in Escherichia coli strain DH5alpha, functional expression in Saccharomyces cerevisiae strain IME043, IME046, and IME047 | Penicillium chrysogenum |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.7.1.1 | Mn2+ | required | Penicillium chrysogenum |  |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.7.1.1 | oxaloacetate + H2O | Penicillium chrysogenum | - |
oxalate + acetate | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.7.1.1 | no activity in Saccharomyces cerevisiae | - |
- |
- |
| 3.7.1.1 | Penicillium chrysogenum | - |
gene Pc22g24830 | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.7.1.1 | oxaloacetate + H2O | - |
Penicillium chrysogenum | oxalate + acetate | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.7.1.1 | OAH | - |
Penicillium chrysogenum |
| 3.7.1.1 | oxaloacetate hydrolase | - |
Penicillium chrysogenum |
Temperature Optimum [°C]
| EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 3.7.1.1 | 25 | - |
assay at | Penicillium chrysogenum |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 3.7.1.1 | 7.5 | - |
assay at | Penicillium chrysogenum |
General Information
| EC Number | General Information | Comment | Organism |
|---|---|---|---|
| 3.7.1.1 | malfunction | deletion of gene Pc22g28430 in Penicillium chrysogenum leads to complete elimination of oxalate production, whilst improving yields of the cephalosporin precursor adipoyl-6-aminopenicillinic acid | Penicillium chrysogenum |
| 3.7.1.1 | physiological function | oxaloacetate hydrolase is generally responsible for oxalate production in filamentous fungi | Penicillium chrysogenum |
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Release 2023.1 (January 2023)
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