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Literature summary extracted from

  • Banerjee, S.; Brown, K.L.; Egli, M.; Stone, M.P.
    Bypass of aflatoxin B1 adducts by the Sulfolobus solfataricus DNA polymerase IV (2011), J. Am. Chem. Soc., 133, 12556-12568.
    View publication on PubMedView publication on EuropePMC

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
2.7.7.7 crystals are grown using the sitting drop vapor diffusion method (pH 7.4 , 25°C). The Dpo4 polymerase is cocrystallized with the aflatoxin B1-formamidopyrimidine-modified template and the structure is determined at 3.0 A resolution. The structures of the ternary complexes are determined at 2.9 and 2.7 A resolutions for the dATP and dTTP complexes, respectively Saccharolobus solfataricus

Organism

EC Number Organism UniProt Comment Textmining
2.7.7.7 Saccharolobus solfataricus Q97W02
-
-
2.7.7.7 Saccharolobus solfataricus P2 Q97W02
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.7.7 deoxynucleoside triphosphate + DNAn the enzyme bypasses aflatoxin B1-N7-dG in an error-free manner but conducts error-prone replication past the aflatoxin B1-formamidopyrimidine adduct, including misinsertion of dATP Saccharolobus solfataricus diphosphate + DNAn+1
-
 ?
2.7.7.7 deoxynucleoside triphosphate + DNAn the enzyme bypasses aflatoxin B1-N7-dG in an error-free manner but conducts error-prone replication past the aflatoxin B1-formamidopyrimidine adduct, including misinsertion of dATP Saccharolobus solfataricus P2 diphosphate + DNAn+1
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.7.7 DNA polymerase IV
-
 Saccharolobus solfataricus
2.7.7.7 Dpo4
-
 Saccharolobus solfataricus