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Literature summary extracted from
- Pentalenic acid is a shunt metabolite in the biosynthesis of the pentalenolactone family of metabolites: hydroxylation of 1-deoxypentalenic acid mediated by CYP105D7 (SAV_7469) of Streptomyces avermitilis (2011), J. Antibiot., 64, 65-71.
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 1.14.15.11 | expression in Escherichia coli | Streptomyces avermitilis |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 1.14.15.11 | 0.027 | - |
1-deoxypentalenic acid | pH 8.0, 25°C | Streptomyces avermitilis |  |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.14.15.11 | Streptomyces avermitilis | Q825I8 | - |
- |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.14.15.11 | 1-deoxypentalenic acid + reduced ferredoxin + O2 | - |
Streptomyces avermitilis | pentalenic acid + oxidized ferredoxin + H2O | - |
? | |
| 1.14.15.11 | additional information | no substrates: pentalenene, 1-deoxy-11beta-hydroxypentalenic acid, 1-deoxy-11-oxopentalenic acid, or the corresponding methyl esters of 1-deoxy-11beta-hydroxypentalenic acid, 1-deoxy-11-oxopentalenic acid and 1-deoxypentalenic acid, respectively | Streptomyces avermitilis | ? | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.14.15.11 | CYP105D7 | - |
Streptomyces avermitilis |
| 1.14.15.11 | CYP28 | - |
Streptomyces avermitilis |
| 1.14.15.11 | SAV_7469 | locus name | Streptomyces avermitilis |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 1.14.15.11 | 8 | - |
- |
Streptomyces avermitilis |
General Information
| EC Number | General Information | Comment | Organism |
|---|---|---|---|
| 1.14.15.11 | physiological function | disruption of the sav7469 gene encoding pentalenic acid synthase abolishes production of pentalenic acid. The deletion mutant accumulates 1-deoxypentalenic acid. Recombinant enzyme prepared from Escherichia coli catalyzes the oxidative conversion of 1-deoxypentalenic acid to pentalenic acid in the presence of the electron-transport partners, ferredoxin and ferredoxin reductase, both in vivo and in vitro | Streptomyces avermitilis |
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Release 2023.1 (January 2023)
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