Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Kimura, Y.; Kawasaki, S.; Yoshimoto, H.; Takegawa, K.
    Glycine betaine biosynthesized from glycine provides an osmolyte for cell growth and spore germination during osmotic stress in Myxococcus xanthus (2010), J. Bacteriol., 192, 1467-1470.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.1.1.156 gene gsmA, DNA and amino acid sequence determination and analysis, sequence comparison Myxococcus xanthus
2.1.1.157 gene sdmA, DNA and amino acid sequence determination and analysis, sequence comparison Myxococcus xanthus

Protein Variants

EC Number Protein Variants Comment Organism
2.1.1.156 additional information construction of a chromosomal gsmA gene disruption knockout mutant, phenotype, overview Myxococcus xanthus
2.1.1.157 additional information construction of a chromosomal sdmA gene disruption knockout mutant, phenotype, overview Myxococcus xanthus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.1.1.156 29500
-
x * 29500, about, sequence calculation Myxococcus xanthus
2.1.1.157 27900
-
x * 27900, about, sequence calculation Myxococcus xanthus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.1.156 S-adenosyl-L-methionine + glycine Myxococcus xanthus
-
S-adenosyl-L-homocysteine + sarcosine
-
?
2.1.1.156 S-adenosyl-L-methionine + sarcosine Myxococcus xanthus
-
S-adenosyl-L-homocysteine + N,N-dimethylglycine
-
?
2.1.1.157 S-adenosyl-L-methionine + N,N-dimethylglycine Myxococcus xanthus
-
S-adenosyl-L-homocysteine + betaine
-
?
2.1.1.157 S-adenosyl-L-methionine + sarcosine Myxococcus xanthus
-
S-adenosyl-L-homocysteine + N,N-dimethylglycine
-
?

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.156 Myxococcus xanthus
-
gene gsmA encodes a Gsm homologue protein
-
2.1.1.157 Myxococcus xanthus
-
gene smdA encodes a Sdm homologue protein
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.156 S-adenosyl-L-methionine + glycine
-
Myxococcus xanthus S-adenosyl-L-homocysteine + sarcosine
-
?
2.1.1.156 S-adenosyl-L-methionine + sarcosine
-
Myxococcus xanthus S-adenosyl-L-homocysteine + N,N-dimethylglycine
-
?
2.1.1.157 S-adenosyl-L-methionine + N,N-dimethylglycine
-
Myxococcus xanthus S-adenosyl-L-homocysteine + betaine
-
?
2.1.1.157 S-adenosyl-L-methionine + sarcosine
-
Myxococcus xanthus S-adenosyl-L-homocysteine + N,N-dimethylglycine
-
?

Subunits

EC Number Subunits Comment Organism
2.1.1.156 ? x * 29500, about, sequence calculation Myxococcus xanthus
2.1.1.157 ? x * 27900, about, sequence calculation Myxococcus xanthus

Synonyms

EC Number Synonyms Comment Organism
2.1.1.156 glycine sarcosine methyltransferase
-
Myxococcus xanthus
2.1.1.156 Gsm
-
Myxococcus xanthus
2.1.1.156 GsmA
-
Myxococcus xanthus
2.1.1.156 MXAN 7068
-
Myxococcus xanthus
2.1.1.157 MXAN 3190
-
Myxococcus xanthus
2.1.1.157 sarcosine dimethylglycine methyltransferase
-
Myxococcus xanthus
2.1.1.157 Sdm
-
Myxococcus xanthus
2.1.1.157 Sdm homologue protein
-
Myxococcus xanthus
2.1.1.157 SdmA
-
Myxococcus xanthus

Cofactor

EC Number Cofactor Comment Organism Structure
2.1.1.156 S-adenosyl-L-methionine
-
Myxococcus xanthus
2.1.1.157 S-adenosyl-L-methionine
-
Myxococcus xanthus

General Information

EC Number General Information Comment Organism
2.1.1.156 malfunction disruption of the gsmA gene, encoding Gsm homologue protein, generates a mutant that exhibits a longer lag period of growth and delayed spore germination under osmostress, it shows normal growth in CYE medium at 30°C, phenotype, overview Myxococcus xanthus
2.1.1.156 metabolism glycine sarcosine methyltransferase and sarcosine dimethylglycine methyltransferase, EC 2.1.1.157, catalyze glycine betaine synthesis from glycine Myxococcus xanthus
2.1.1.157 malfunction disruption of the sdmA gene, encoding Sdm homologue protein, generates a mutant that exhibits a longer lag period of growth and delayed spore germination under osmostress, it shows normal growth in CYE medium at 30°C, phenotype, overview Myxococcus xanthus
2.1.1.157 metabolism glycine sarcosine methyltransferase, EC 2.1.1.156, and sarcosine dimethylglycine methyltransferase catalyze glycine betaine synthesis from glycine Myxococcus xanthus