Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Nishimura, Y.; Eguchi, T.
    Biosynthesis of archaeal membrane lipids: digeranylgeranylglycerophospholipid reductase of the thermoacidophilic archaeon Thermoplasma acidophilum (2006), J. Biochem., 139, 1073-1081.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.3.1.101 additional information EDTA has little effect on activity Thermoplasma acidophilum

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.3.1.101 membrane membrane associated protein Thermoplasma acidophilum 16020
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.3.1.101 additional information the enzyme does not require metal ions for activity Thermoplasma acidophilum

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.3.1.101 45000
-
 x * 45000, SDS-PAGE Thermoplasma acidophilum

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.3.1.101 2,3-bis-O-geranylgeranyl-sn-glycerol 1-phosphate + 8 NAD(P)H + 8 H+ Thermoplasma acidophilum formation of 2,3-di-O-phytanyl-sn-glyceryl phosphate (archaetidic acid), which is the basic core structure of archaeal membrane lipids 2,3-bis-O-phytanyl-sn-glycerol 1-phosphate + 8 NAD(P)+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.3.1.101 Thermoplasma acidophilum Q9HKS9
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.3.1.101
-
 Thermoplasma acidophilum

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.3.1.101 0.0115
-
 pH 6.5, 50°C, substrate: 2,3-di-O-geranylgeranyl-sn-glycerol 1-phosphate Thermoplasma acidophilum

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.1.101 2,3-bis-O-geranylgeranyl-sn-glycerol 1-phosphate + 8 NAD(P)H + 8 H+
-
 Thermoplasma acidophilum 2,3-bis-O-phytanyl-sn-glycerol 1-phosphate + 8 NAD(P)+
-
 ?
1.3.1.101 2,3-bis-O-geranylgeranyl-sn-glycerol 1-phosphate + 8 NAD(P)H + 8 H+ formation of 2,3-di-O-phytanyl-sn-glyceryl phosphate (archaetidic acid), which is the basic core structure of archaeal membrane lipids Thermoplasma acidophilum 2,3-bis-O-phytanyl-sn-glycerol 1-phosphate + 8 NAD(P)+
-
 ?
1.3.1.101 2,3-bis-O-phytyl-sn-glycero-phosphoethanolamine + NAD(P)H + H+
-
 Thermoplasma acidophilum ?
-
 ?
1.3.1.101 2,3-bis-O-phytyl-sn-glyceryl phosphate + NAD(P)H + H+
-
 Thermoplasma acidophilum 2,3-bis-O-phytanyl-sn-glycerol 1-phosphate + NAD(P)+
-
 ?
1.3.1.101 3-O-(2,3-bis-O-phytyl-sn-glycero-phospho)-sn-glycerol + NAD(P)H + H+
-
 Thermoplasma acidophilum ?
-
 ?
1.3.1.101 additional information neither 2,3-bis-O-geranylgeranylglycerol nor 2,3-bis-O-geranylgeranylglyceryl phosphate dimethyl ester is recognized as a substrate Thermoplasma acidophilum ?
-
 ?

Subunits

EC Number Subunits Comment Organism
1.3.1.101 ? x * 45000, SDS-PAGE Thermoplasma acidophilum

Synonyms

EC Number Synonyms Comment Organism
1.3.1.101 Ta0516m
-
 Thermoplasma acidophilum

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.3.1.101 50
-
 aassay at Thermoplasma acidophilum

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.3.1.101 6.5
-
 assay at Thermoplasma acidophilum

Cofactor

EC Number Cofactor Comment Organism Structure
1.3.1.101 FAD required for activity Thermoplasma acidophilum
1.3.1.101 NAD(P)H required for activity Thermoplasma acidophilum