Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Hasegawa, S.; Noda, K.; Maeda, A.; Matsuoka, M.; Yamasaki, M.; Fukui, T.
    Acetoacetyl-CoA synthetase, a ketone body-utilizing enzyme, is controlled by SREBP-2 and affects serum cholesterol levels (2012), Mol. Genet. Metab., 107, 553-560.
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
6.2.1.16 cytosol
-
 Mus musculus 5829
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.2.1.16 ATP + acetoacetate + CoA Mus musculus
-
 AMP + diphosphate + acetoacetyl-CoA
-
 ?
6.2.1.16 ATP + acetoacetate + CoA Mus musculus ddY
-
 AMP + diphosphate + acetoacetyl-CoA
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
6.2.1.16 Mus musculus
-
-
-
6.2.1.16 Mus musculus ddY
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
6.2.1.16 hepatocyte primary Mus musculus
-
6.2.1.16 liver
-
 Mus musculus
-
6.2.1.16 additional information AACS mRNA levels are dramatically increased in mice that are fed hypocholesterolemic agents Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.2.1.16 ATP + acetoacetate + CoA
-
 Mus musculus AMP + diphosphate + acetoacetyl-CoA
-
 ?
6.2.1.16 ATP + acetoacetate + CoA
-
 Mus musculus ddY AMP + diphosphate + acetoacetyl-CoA
-
 ?

Synonyms

EC Number Synonyms Comment Organism
6.2.1.16 AACS
-
 Mus musculus
6.2.1.16 Acetoacetyl-CoA synthetase
-
 Mus musculus

Cofactor

EC Number Cofactor Comment Organism Structure
6.2.1.16 ATP
-
 Mus musculus

Expression

EC Number Organism Comment Expression
6.2.1.16 Mus musculus treatment of hepatocytes with U18666A results in the upregulation of AACS gene expression up

General Information

EC Number General Information Comment Organism
6.2.1.16 metabolism AACS is involved in the pathway of ketone body metabolism, overview Mus musculus
6.2.1.16 additional information transcription mechanism of AACS, expression of AACS is regulated by cholesterol depletion, overview Mus musculus
6.2.1.16 physiological function AACS plays an important role in cholesterol homeostasis Mus musculus