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Literature summary extracted from

  • Mander, G.J.; Duin, E.C.; Linder, D.; Stetter, K.O.; Hedderich, R.
    Purification and characterization of a membrane-bound enzyme complex from the sulfate-reducing archaeon Archaeoglobus fulgidus related to heterodisulfide reductase from methanogenic archaea (2002), Eur. J. Biochem., 269, 1895-1904.
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.1.99.B7 membrane membrane-bound enzyme complex Archaeoglobus fulgidus 16020
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Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.1.99.B7 Iron-sulfur cluster contains [4Fe-4S]+ clusters Archaeoglobus fulgidus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.1.99.B7 16700
-
 x * 64400 (Hme subunit D) + x * 38000 (Hme subunit C) + x * 30500 (Hme subunit A) + x * 16700 (Hme subunit E), SDS-PAGE Archaeoglobus fulgidus
1.1.99.B7 30500
-
 x * 64400 (Hme subunit D) + x * 38000 (Hme subunit C) + x * 30500 (Hme subunit A) + x * 16700 (Hme subunit E), SDS-PAGE Archaeoglobus fulgidus
1.1.99.B7 38000
-
 x * 64400 (Hme subunit D) + x * 38000 (Hme subunit C) + x * 30500 (Hme subunit A) + x * 16700 (Hme subunit E), SDS-PAGE Archaeoglobus fulgidus
1.1.99.B7 64400
-
 x * 64400 (Hme subunit D) + x * 38000 (Hme subunit C) + x * 30500 (Hme subunit A) + x * 16700 (Hme subunit E), SDS-PAGE Archaeoglobus fulgidus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.99.B7 additional information Archaeoglobus fulgidus the enzyme plays a key role in the energy metabolism of methanogenic archaea ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.99.B7 Archaeoglobus fulgidus O29751 and O29749 and O29748 and O29747 O29751: extracytoplasmic iron-sulfur protein 1 (Hme subunit A), O29749: Hdr-like menaquinol oxidoreductase cytochrome b-like subunit (Hme subunit C), O29748: Hdr-like menaquinol oxidoreductase iron-sulfur subunit 2 (Hme subunit D), O29747: Hdr-like menaquinol oxidoreductase cytochrome c subunit (Hme subunit E)
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Purification (Commentary)

EC Number Purification (Comment) Organism
1.1.99.B7
-
 Archaeoglobus fulgidus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.99.B7 2,3-dimethyl-1,4-naphthoquinone + reduced coenzyme F420
-
 Archaeoglobus fulgidus 2,3-dimethyl-1,4-naphthoquinol + oxidized coenzyme F420
-
 ?
1.1.99.B7 additional information the enzyme plays a key role in the energy metabolism of methanogenic archaea Archaeoglobus fulgidus ?
-
 ?

Subunits

EC Number Subunits Comment Organism
1.1.99.B7 oligomer x * 64400 (Hme subunit D) + x * 38000 (Hme subunit C) + x * 30500 (Hme subunit A) + x * 16700 (Hme subunit E), SDS-PAGE Archaeoglobus fulgidus

Synonyms

EC Number Synonyms Comment Organism
1.1.99.B7 Hme complex
-
 Archaeoglobus fulgidus
1.1.99.B7 menaquinol oxidoreductase
-
 Archaeoglobus fulgidus

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.99.B7 heme heme/iron-sulfur protein. The heme groups of the enzyme are rapidly reduced by reduced 2,3-dimethyl-1,4-naphthoquinone, which indicates that the enzyme functions as a menaquinol-acceptor oxidoreductase Archaeoglobus fulgidus

General Information

EC Number General Information Comment Organism
1.1.99.B7 physiological function the enzyme plays a key role in the energy metabolism of methanogenic archaea Archaeoglobus fulgidus