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Literature summary extracted from

  • Martens-Uzunova, E.S.; Schaap, P.J.
    An evolutionary conserved D-galacturonic acid metabolic pathway operates across filamentous fungi capable of pectin degradation (2008), Fungal Genet. Biol., 45, 1449-1457.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.1.1.365 expressed in Escherichia coli DH5alpha cells Aspergillus niger

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.365 0.036
-
NADPH with D-galacturonate as cosubstrate, in 10 mM sodium phosphate, at pH 7.2 and 22°C Aspergillus niger
1.1.1.365 0.175
-
D-galacturonate with NADPH as cosubstrate, in 10 mM sodium phosphate, at pH 7.2 and 22°C Aspergillus niger
1.1.1.365 0.326
-
NADH with D-galacturonate as cosubstrate, in 10 mM sodium phosphate, at pH 7.2 and 22°C Aspergillus niger
1.1.1.365 7.11
-
D-galacturonate with NADH as cosubstrate, in 10 mM sodium phosphate, at pH 7.2 and 22°C Aspergillus niger

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.1.1.365 44000
-
x * 44000, His6-tagged enzyme, SDS-PAGE Aspergillus niger

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.365 D-galacturonate + NADPH + H+ Aspergillus niger
-
L-galactonate + NADP+
-
?
1.1.1.365 D-galacturonate + NADPH + H+ Aspergillus niger CBS 120.49
-
L-galactonate + NADP+
-
?
1.1.1.372 L-glyceraldehyde + NADPH + H+ Aspergillus niger
-
glycerol + NADP+
-
?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.365 Aspergillus niger
-
-
-
1.1.1.365 Aspergillus niger CBS 120.49
-
-
-
1.1.1.372 Aspergillus niger
-
-
-
4.1.2.54 Aspergillus niger A8DRH7
-
-
4.1.2.54 Aspergillus niger CBS 120.49 A8DRH7
-
-
4.1.2.54 Trichoderma reesei A6Y9S5
-
-
4.1.2.54 Trichoderma reesei CBS 383.78 (QM6a) A6Y9S5
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.365 mycelium
-
Aspergillus niger
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.1.1.365 0.12
-
with NAD+ and L-galactonate as substrates, in 10 mM sodium phosphate, at pH 7.2 and 22°C Aspergillus niger
1.1.1.365 0.17
-
with NADH and D-glucuronate as substrates, in 10 mM sodium phosphate, at pH 7.2 and 22°C Aspergillus niger
1.1.1.365 0.21
-
with NADP+ and L-galactonate as substrates, in 10 mM sodium phosphate, at pH 7.2 and 22°C Aspergillus niger
1.1.1.365 3.9
-
with NADPH and D-glucuronate as substrates, in 10 mM sodium phosphate, at pH 7.2 and 22°C Aspergillus niger
1.1.1.365 6.9
-
with NADH and D-galacturonate as substrates, in 10 mM sodium phosphate, at pH 7.2 and 22°C Aspergillus niger
1.1.1.365 8.7
-
with NADPH and D-galacturonate as substrates, in 10 mM sodium phosphate, at pH 7.2 and 22°C Aspergillus niger

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.365 D-galacturonate + NADH + H+
-
Aspergillus niger L-galactonate + NAD+
-
r
1.1.1.365 D-galacturonate + NADH + H+
-
Aspergillus niger CBS 120.49 L-galactonate + NAD+
-
r
1.1.1.365 D-galacturonate + NADPH + H+
-
Aspergillus niger L-galactonate + NADP+
-
?
1.1.1.365 D-galacturonate + NADPH + H+
-
Aspergillus niger L-galactonate + NADP+
-
r
1.1.1.365 D-galacturonate + NADPH + H+
-
Aspergillus niger CBS 120.49 L-galactonate + NADP+
-
?
1.1.1.365 D-galacturonate + NADPH + H+
-
Aspergillus niger CBS 120.49 L-galactonate + NADP+
-
r
1.1.1.365 D-glucuronate + NADH + H+
-
Aspergillus niger ?
-
?
1.1.1.365 D-glucuronate + NADH + H+
-
Aspergillus niger CBS 120.49 ?
-
?
1.1.1.365 D-glucuronate + NADPH + H+
-
Aspergillus niger ?
-
?
1.1.1.365 D-glucuronate + NADPH + H+
-
Aspergillus niger CBS 120.49 ?
-
?
1.1.1.365 L-galactonate + NAD+
-
Aspergillus niger D-galacturonate + NADH + H+
-
r
1.1.1.365 L-galactonate + NADP+
-
Aspergillus niger D-galacturonate + NADPH + H+
-
r
1.1.1.372 L-glyceraldehyde + NADPH + H+
-
Aspergillus niger glycerol + NADP+
-
?

Subunits

EC Number Subunits Comment Organism
1.1.1.365 ? x * 44000, His6-tagged enzyme, SDS-PAGE Aspergillus niger

Synonyms

EC Number Synonyms Comment Organism
1.1.1.365 gaaA
-
Aspergillus niger
1.1.1.372 gaaD
-
Aspergillus niger
1.1.1.372 L-glyceraldehyde reductase
-
Aspergillus niger
4.1.2.54 GAAC
-
Aspergillus niger
4.1.2.54 Kdg1
-
Trichoderma reesei

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
1.1.1.365 0.08
-
L-galactonate with NAD+ as cosubstrate, in 10 mM sodium phosphate, at pH 7.2 and 22°C Aspergillus niger
1.1.1.365 0.13
-
D-glucuronate with NADH as cosubstrate, in 10 mM sodium phosphate, at pH 7.2 and 22°C Aspergillus niger
1.1.1.365 0.16
-
L-galactonate with NADP+ as cosubstrate, in 10 mM sodium phosphate, at pH 7.2 and 22°C Aspergillus niger
1.1.1.365 3.11
-
D-glucuronate with NADPH as cosubstrate, in 10 mM sodium phosphate, at pH 7.2 and 22°C Aspergillus niger
1.1.1.365 4.98
-
NADH with D-galacturonate as cosubstrate, in 10 mM sodium phosphate, at pH 7.2 and 22°C Aspergillus niger
1.1.1.365 5.45
-
D-galacturonate with NADH as cosubstrate, in 10 mM sodium phosphate, at pH 7.2 and 22°C Aspergillus niger
1.1.1.365 6.88
-
D-galacturonate with NADPH as cosubstrate, in 10 mM sodium phosphate, at pH 7.2 and 22°C Aspergillus niger
1.1.1.365 7.11
-
NADPH with D-galacturonate as cosubstrate, in 10 mM sodium phosphate, at pH 7.2 and 22°C Aspergillus niger

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.365 NADH
-
Aspergillus niger
1.1.1.365 NADPH preferred cofactor Aspergillus niger
1.1.1.372 NADPH
-
Aspergillus niger

kcat/KM [mM/s]

EC Number kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
1.1.1.365 0.767
-
D-galacturonate with NADH as cosubstrate, in 10 mM sodium phosphate, at pH 7.2 and 22°C Aspergillus niger
1.1.1.365 15.72
-
NADH with D-galacturonate as cosubstrate, in 10 mM sodium phosphate, at pH 7.2 and 22°C Aspergillus niger
1.1.1.365 39.29
-
D-galacturonate with NADPH as cosubstrate, in 10 mM sodium phosphate, at pH 7.2 and 22°C Aspergillus niger
1.1.1.365 197.2
-
NADPH with D-galacturonate as cosubstrate, in 10 mM sodium phosphate, at pH 7.2 and 22°C Aspergillus niger