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Literature summary extracted from

  • Sakuno, E.; Yabe, K.; Hamasaki, T.; Nakajima, H.
    A new inhibitor of 5-hydroxyaverantin dehydrogenase, an enzyme involved in aflatoxin biosynthesis, from Trichoderma hamatum (2000), J. Nat. Prod., 63, 1677-1678.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.352 4,6-dihydroxy-5-methoxy-6a-methylcyclohexa[de]indano-[7,6-e]cyclopenta[c]2H-pyran-1,9-dione TAEMC161, specific inhibitor Aspergillus parasiticus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.1.1.352 cytosol
-
 Aspergillus parasiticus 5829
-

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.352 Aspergillus parasiticus
-
-
-
1.1.1.352 Aspergillus parasiticus NIAH-26
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.1.1.352 ammonium sulfate precipitation, butyl-Toyopearl 650 M column chromatography Aspergillus parasiticus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.352 mycelium
-
 Aspergillus parasiticus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.352 (1'S,5'S)-hydroxyaverantin + NAD+
-
 Aspergillus parasiticus 5'-oxoaverantin + NADH + H+
-
 ?
1.1.1.352 (1'S,5'S)-hydroxyaverantin + NAD+
-
 Aspergillus parasiticus NIAH-26 5'-oxoaverantin + NADH + H+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.352 HAVN dehydrogenase
-
 Aspergillus parasiticus

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.352 NAD+
-
 Aspergillus parasiticus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.1.1.352 0.25
-
 in 50 mM Tris-HCl buffer (pH 8.5), at 33°C Aspergillus parasiticus 4,6-dihydroxy-5-methoxy-6a-methylcyclohexa[de]indano-[7,6-e]cyclopenta[c]2H-pyran-1,9-dione