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Literature summary extracted from

  • Mutahir, Z.; Larsen, N.B.; Christiansen, L.S.; Andersson, K.M.; Rico, R.; Wisen, S.M.; Clausen, A.R.; Munch-Petersen, B.; Piskur, J.
    Characterization of oligomeric and kinetic properties of tomato thymidine kinase 1 (2011), Nucleosides Nucleotides Nucleic Acids, 30, 1223-1226.
    View publication on PubMed

Application

EC Number Application Comment Organism
2.7.1.21 medicine the thymidine kinase 1 gene from tomato in combination with azidothymidine is a powerful suicide gene for anticancer gene therapy Solanum lycopersicum

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.1.21 expressed in Escherichia coli KY895 cells Solanum lycopersicum

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.7.1.21 25600
-
 2 * 25600, calculated from amino acid sequence Solanum lycopersicum
2.7.1.21 38000
-
 thymidine kinase 1 without ATP, gel filtration Solanum lycopersicum
2.7.1.21 59000
-
 thymidine kinase 1 with ATP, gel filtration Solanum lycopersicum

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.21 Solanum lycopersicum Q71F77
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.21 ATP + azidothymidine
-
 Solanum lycopersicum ?
-
 ?
2.7.1.21 ATP + azidothymidine monophosphate
-
 Solanum lycopersicum ?
-
 ?
2.7.1.21 ATP + thymidine
-
 Solanum lycopersicum ADP + dTMP
-
 ?

Subunits

EC Number Subunits Comment Organism
2.7.1.21 homodimer 2 * 25600, calculated from amino acid sequence Solanum lycopersicum

Synonyms

EC Number Synonyms Comment Organism
2.7.1.21 thymidine kinase 1
-
 Solanum lycopersicum
2.7.1.21 TK1
-
 Solanum lycopersicum