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Literature summary extracted from

  • Riera, J.; Robb, F.T.; Weiss, R.; Fontecave, M.
    Ribonucleotide reductase in the archaeon Pyrococcus furiosus: a critical enzyme in the evolution of DNA genomes? (1997), Proc. Natl. Acad. Sci. USA, 94, 475-478.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.17.4.1
-
 Pyrococcus furiosus

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.17.4.1 dATP
-
 Pyrococcus furiosus

Organism

EC Number Organism UniProt Comment Textmining
1.17.4.1 Pyrococcus furiosus E7FHX6
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.17.4.1
-
 Pyrococcus furiosus

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.17.4.1 0.51
-
 pH 7.5, 80°C Pyrococcus furiosus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.17.4.1 CDP + reduced dithiothreitol
-
 Pyrococcus furiosus 2'-dCDP + oxidized dithiothreitol + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.17.4.1 ribonucleotide reductase
-
 Pyrococcus furiosus
1.17.4.1 RNR
-
 Pyrococcus furiosus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.17.4.1 80
-
 assay at Pyrococcus furiosus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.17.4.1 7.5
-
 assay at Pyrococcus furiosus

Cofactor

EC Number Cofactor Comment Organism Structure
1.17.4.1 adenosylcobalamin absolutely requires adenosylcobalamin (as a radical generator) for activity, KM: 0.001 mM Pyrococcus furiosus