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Literature summary extracted from

  • Jang, E.H.; Lim, J.E.; Chi, Y.M.; Lee, K.S.
    Crystallization and preliminary X-ray crystallographic studies of succinic semialdehyde dehydrogenase from Streptococcus pyogenes (2012), Acta Crystallogr. Sect. F, 68, 288-291.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.2.1.16 expressed in Escherichia coli BL21 (DE3) cells Streptococcus pyogenes

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
1.2.1.16 apoenzyme and in complex with NAD+, hanging drop vapor diffusion method, using 0.1 M MES monohydrate pH 5.8-6.1 and 18-23% (w/v) polyethylene glycol 4000 Streptococcus pyogenes

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.2.1.16 52000
-
 2 * 52000, SDS-PAGE Streptococcus pyogenes

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.2.1.16 succinate semialdehyde + NAD+ + H2O Streptococcus pyogenes
-
 succinate + NADH + H+
-
 ?
1.2.1.16 succinate semialdehyde + NADP+ + H2O Streptococcus pyogenes
-
 succinate + NADPH + H+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.2.1.16 Streptococcus pyogenes
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.2.1.16 succinate semialdehyde + NAD+ + H2O
-
 Streptococcus pyogenes succinate + NADH + H+
-
 ?
1.2.1.16 succinate semialdehyde + NADP+ + H2O
-
 Streptococcus pyogenes succinate + NADPH + H+
-
 ?

Subunits

EC Number Subunits Comment Organism
1.2.1.16 homodimer 2 * 52000, SDS-PAGE Streptococcus pyogenes

Synonyms

EC Number Synonyms Comment Organism
1.2.1.16 NAD+/NADP+-dependent SSADH
-
 Streptococcus pyogenes
1.2.1.16 SSADH
-
 Streptococcus pyogenes
1.2.1.16 succinic semialdehyde dehydrogenase
-
 Streptococcus pyogenes

Cofactor

EC Number Cofactor Comment Organism Structure
1.2.1.16 NAD+
-
 Streptococcus pyogenes
1.2.1.16 NADP+
-
 Streptococcus pyogenes