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Literature summary extracted from

  • Mikami, Y.; Shibuya, N.; Kimura, Y.; Nagahara, N.; Ogasawara, Y.; Kimura, H.
    Thioredoxin and dihydrolipoic acid are required for 3-mercaptopyruvate sulfurtransferase to produce hydrogen sulfide (2011), Biochem. J., 439, 479-485.
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
2.8.1.2 C247S inactive Mus musculus
2.8.1.2 R187G inactive Mus musculus
2.8.1.2 R196G the mutant shows reduced H2S-producing activity Mus musculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.8.1.2 sulfite H2S production by the enzyme is suppressed by sulfite Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.8.1.2 mitochondrion
-
 Mus musculus 5739
-

Organism

EC Number Organism UniProt Comment Textmining
2.8.1.2 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.8.1.2 brain
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.8.1.2 3-mercaptopyruvate + thiosulfate
-
 Mus musculus pyruvate + H2S
-
 ?
2.8.1.2 additional information the enzyme produces hydrogen sulfide in the presence of both cysteine and 2-oxoglutarate. Thioredoxin and dihydrolipoic acid associate with 3-mercaptopyruvate sulfurtransferase to produce hydrogen sulfide. Other reducing substances, such as NADPH, NADH, GSH, cysteine and CoA, do not have any effect on the reaction Mus musculus ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.8.1.2 3MST
-
 Mus musculus